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0S12A5_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameSLC12A5
DescriptionSolute carrier family 12 member 5 (electroneutral potassium-chloride cotransporter 2) (erythroid k-cl cotransporter 2) (neuronal k-cl cotransporter) (hkcc2).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0016021 integral to membrane (NAS)
0015379 chloride symporter activity (NAS)
0006873 cell ion homeostasis (NAS)
0006810 transport (NAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains assigned to SynO:
The K-Cl co-transporter (KCC) mediates the coupled movement of K+ and Cl-ions across the plasma membrane of many animal cells. This transport isinvolved in the regulatory volume decrease in response to cell swelling inred blood cells.nd has been proposed to play a role in the vectorialmovement of Cl- across kidney epithelia. The transport process involves onefor one electroneutral movement of K+ together with Cl-.nd.n allknown mammalian cells.he net movement is outward .In neurones.t appears to play a unique role in maintaining lowintracellular Cl-concentration.hich is required for the functioning of Cl-dependent fast synaptic inhibition.ediated by certain neurotransmitters.uch as gamma-aminobutyric acid (GABA) and glycine.Two isoforms of the K-Cl co-transporter have been described.ermed KCC1 andKCC2.ontaining 1085 and 1116 amino acids.espectively. They are bothpredicted to have 12 transmembrane (TM) regions in a central hydrophobicdomain.ogether with hydrophilic N- and C-termini that are likelycytoplasmic. Comparison of their sequences with those of otherion-transporting membrane proteins reveals that they are part of a newsuperfamily of cation-chloride co-transporters.hich includes the Na-Cl andNa-K-2Cl co-transporters. KCC1 is widely expressed in human tissues.hileKCC2 is expressed only in brain neurones.aking it likely that this is theisoform responsible for maintaining low Cl- concentration in neurones .
  IPR000076:K-Cl co-transporter
InterPro domains unassigned to SynO:
Amino acid permeases are integral membrane proteins involved in the transport of amino acids into the cell. A number of such proteins have been found to be evolutionary related . These proteins seem to contain up to 12 transmembrane segments. The best conserved region in this family is located in the second transmembrane segment.This domain is found in a wide variety of permeases.s well as several hypothetical proteins.
  IPR004841:Amino acid permease-associated region
This is a family of K-Cl cotransporters. It includes bumetanide-sensitive sodium-(potassium)-chloride cotransporter.n electrically silent transporter system which is a mediator of sodium and chloride reabsorption. It plays a vital role in the regulation of ionic balance and cell volume. Bumetanide-sensitive sodium-(potassium)-chloride cotransporter belongs to the SLC12A family of transporters.
  IPR004842:Na-K-Cl cotransporter superfamily
IPR004841:AA_permease 
Evalue:-23.7695503234863 
Location:102-676IPR000076:KCLTRNSPORT 
Evalue:0 
Location:43-51IPR000076:KCLTRNSPORT 
Evalue:0 
Location:23-29
SequencesProtein: S12A5_HUMAN (1116 aa)
mRNA: NM_020708
Local Annotation
Synapse Ontology
all kinds of ion channels that play their roles in the synaptic activity.
sdb:0308 ion channels and receptors  (Evidence:domains)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 67 residues, 44091244-44091442Exon2: 33 residues, 44096993-44097088Exon3: 46 residues, 44097449-44097581Exon4: 51 residues, 44097822-44097969Exon5: 20 residues, 44098786-44098841Exon6: 45 residues, 44099300-44099431Exon7: 82 residues, 44102418-44102660Exon8: 72 residues, 44103374-44103586Exon9: 59 residues, 44105198-44105369Exon10: 35 residues, 44105678-44105777Exon11: 21 residues, 44105921-44105979Exon12: 60 residues, 44107011-44107186Exon13: 41 residues, 44107923-44108042Exon14: 35 residues, 44108383-44108482Exon15: 42 residues, 44109499-44109619Exon16: 37 residues, 44110026-44110131Exon17: 58 residues, 44111667-44111836Exon18: 67 residues, 44113720-44113916Exon19: 58 residues, 44115002-44115172Exon20: 46 residues, 44115623-44115755Exon21: 38 residues, 44116961-44117069Exon22: 43 residues, 44118195-44118318Exon23: 68 residues, 44118410-44118610Exon24: 7 residues, 44118942-44118957Exon25: 46 residues, 44119215-44119349Exon26: 881 residues, 44119559-44122196Exon27: 2 residues, -Jump to S12A5_HUMAN  
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Loci Cluster (Details)Loci: 4525 44123034-44151987 ~-29K 23235(NCOA5)(-)Loci: 3261 44091244-44122196 ~-31K 23234(SLC12A5)(+)Link out to UCSC