SynDB Home Page
SynDB Home Page
Browse
Search
Download
Help
People
links

blue bulletSynDB protein details  


Parse error: syntax error, unexpected T_VARIABLE in /home/kongl/syndb/www/sdb_nats.php on line 52
0RYR3_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameRYR3
DescriptionRyanodine receptor 3 (brain-type ryanodine receptor) (ryr3) (ryr-3) (brain ryanodine receptor-calcium release channel).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0015278 calcium-release channel activity (TAS)
0006816 calcium ion transport (TAS)

Warning: fopen(/home/kongl/syndb/www/temp/672809236.dot) [function.fopen]: failed to open stream: Permission denied in /home/kongl/syndb/www/sdb_pro.php on line 269

Warning: fwrite(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 270

Warning: fwrite(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 271

Warning: fwrite(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 272

Warning: fwrite(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 273

Warning: fwrite(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 274

Warning: fwrite(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 299

Warning: fclose(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 300
schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains assigned to SynO:
This is a domain found in ryanodine.nositol trisphosphate receptor and protein O-mannosyltransferase. Inositol 1..-trisphosphate (InsP3) is an intracellular second messenger that transduces growth factor and neurotransmitter signals. InsP3 mediates the release of Ca2+ from intracellular stores by binding to specific Ca2+ channel-coupled receptors. Ryanodine receptors are involved in communication between transverse-tubules and the sarcoplamic reticulum of cardiac and skeletal muscle. The proteins function as a Ca2+-release channels following depolarisation of transverse-tubules . The function is modulated by Ca2+.g2+.TP and calmodulin. Deficiency in the ryanodine receptor may be the cause of malignant hyperthermia (MH) and of central core disease of muscle (CCD) . protein O-mannosyltransferases transfer mannose from DOL-P-mannose to ser or thr residues on proteins.
  IPR003608:MIR
InterPro domains unassigned to SynO:
This eukaryotic domain is found in ryanodine receptors (RyR) and inositol 1..-trisphosphate receptors (IP3R) which together form a superfamily of homotetrameric ligand-gated intracellular Ca2+ channels . There seems to be no known function for this domain . Also see the IP3-binding domain and .
  IPR013662:RyR and IP3R Homology associated
The release of Ca2+ ions from intracellular stores is a key step in a wide variety of cellular functions. In striated muscle.he release of Ca2+ from the sarcoplasmic reticulum (SR) leads to muscle contraction. Ca2+ release occurs through large.igh-conductance Ca2+ release channels.lso known as ryanodine receptors (RyRs) because they bind the plant alkaloid ryanodine with high affinity and specificity .This region covers TM regions 4-6 of the ryanodine receptor 1 family.
  IPR009460:Ryanodine Receptor TM 4-6
Ryanodine and Inositol 1..-trisphosphate (IP3) receptors are intracellular Ca2+-release channels. They become activated upon binding of their respective ligands.a2+ and IP3.pening an intrgral Ca2+ channel. Ryanodine receptor activation is a key component of muscular contraction.heir activation allowing release of Ca2+ from the sarcoplasmic reticulum. Mutations in the ryanodine receptor lead to malignant hyperthermia susceptibility the and central core disease of muscle.
  IPR000699:Intracellular calcium-release channel
This domain is called RyR for Ryanodine receptor . The domain is found in four copies in the ryanodine receptor. The function of this domain is unknown.
  IPR003032:Ryanodine receptor Ryr
The SPRY domain is of unknown function. Distant homologues are domains inbutyrophilin/marenostrin/pyrin .Ca2+-release from the sarcoplasmic or endoplasmic reticulum.he intracellular Ca2+ store.s mediated by the ryanodine receptor (RyR) and/or the inositol trisphosphate receptor (IP3R).
  IPR003877:SPla/RYanodine receptor SPRY
This group of proteins is found in sodium.otassium.nd calcium ion channels proteins. The proteins have 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some Na channels proteins the domain is repeated four times.hereas in others (e.g. K channels) the protein forms a tetramer in the membrane. A bacterial structure of the protein is known for the last two helices but is not included in the Pfam family due to it lacking the first four helices.
  IPR005821:Ion transport
Many calcium-binding proteins belong to the same evolutionary family and share a type of calcium-binding domain known as the EF-hand. This type of domain consists of a twelve residue loop flanked on both side by a twelve residue alpha-helical domain. In an EF-hand loop the calcium ion is coordinated in a pentagonal bipyramidal configuration. The six residues involved in the binding are in positions 1.... and 12; these residues are denoted by X...Y.X and -Z. The invariant Glu or Asp at position 12 provides two oxygens for liganding Ca (bidentate ligand).
  IPR002048:Calcium-binding EF-hand
This domain consists of a duplication of two EF-hand units.here each unit is composed of two helices connected by a twelve-residue calcium-binding loop. The calcium ion in the EF-hand loop is coordinated in a pentagonal bipyramidal configuration. Many calcium-binding proteins contain an EF-hand type calcium-binding domain . These include: calbindin D9K.100 proteins such as calcyclin.olcalcin phl p 7 (a calcium-binding pollen allergen).steonectin.arvalbumin.almodulin family of proteins (troponin C.altractin.dc4p.yosin essential chain.alcineurin.ecoverin.eurocalcin).lasmodial-specific CaII-binding protein Cbp40.enta-EF-Hand proteins (sorcin.rancalcin.alpain).s well as multidomain proteins such as phosphoinositide-specific phospholipase C.ystrophin.b1 and alpha-actinin. The fold consists of four helices and an open array of two hairpins.
  IPR011992:EF-Hand type
Ryanodine receptors are involved in communication between transverse-tubulesand the sarcoplamic reticulum of cardiac and skeletal muscle. The proteinsfunction as a Ca2+-release channels following depolarisation of transverse-tubules . The function is modulated by Ca2+.g2+.TP and calmodulin.Deficiency in the ryanodine receptor may be the cause of malignanthyperthermia (MH) and of central core disease of muscle (CCD) . MH isan autosomal dominant disorder of skeletal muscle and is a principalcause of death due to anaesthesia.Calcium release activity of the receptors resides in the C-terminal regionof the protein.he remaining part of the molecule forming a footstructure that spans the junctional gap between the sarcoplamic reticulumand the transverse-tubule. The foot structure may interact with thecytoplasmic region of the dihydropyridine receptor.Analysis of the sequence reveals 10 potential transmembrane (TM) regionsin the C-terminal fifth of the molecule and 2 further potential TM regionsnearer to the centre . These may contribute to the formation of the Ca2+conducting pore. The rest of the sequence is hydrophilic.nd presumablyconstitutes the cytoplasmic domain of the protein.
  IPR013333:Ryanodine receptor, N-terminal
IPR013662:RIH_assoc 
Evalue:-255.397933959961 
Location:3366-3856IPR009460:RR_TM4-6 
Evalue:-132 
Location:4234-4504IPR000699:RYDR_ITPR 
Evalue:-94.6989669799805 
Location:438-642IPR003608:MIR 
Evalue:-77.6197891235352 
Location:216-398IPR000699:RYDR_ITPR 
Evalue:-77.0362091064453 
Location:2019-2229IPR003032:RyR 
Evalue:-53.1426658630371 
Location:962-1056IPR003032:RyR 
Evalue:-52.9208183288574 
Location:848-942IPR003032:RyR 
Evalue:-48.8239097595215 
Location:2597-2691IPR003877:SPRY 
Evalue:-38.4202156066895 
Location:1084-1207IPR003877:SPRY 
Evalue:-37.5376014709473 
Location:1325-1465IPR003877:SPRY 
Evalue:-34.7958793640137 
Location:657-795IPR003032:RyR 
Evalue:-33.1870880126953 
Location:2715-2803IPR005821:Ion_trans 
Evalue:-14.2146701812744 
Location:4639-4769IPR002048:efhand 
Evalue:-3.79588007926941 
Location:3923-3951IPR003608:MIR 
Evalue:-3.56863623584101 
Location:100-155IPR003608:MIR 
Evalue:-3.26760624017703 
Location:162-207IPR013333:RYANODINER 
Evalue:0 
Location:60-81
SequencesProtein: RYR3_HUMAN (4870 aa)
mRNA: AB001025 NM_001036
Local Annotation
Synapse Ontology
Any process that activates or increases the rate, frequency or extent of synaptic growth at neuromuscular junction.
sdb:0047 positive regulation of synaptic growth at neuromuscular junction  (Evidence:keywords,domains)
those channels, like InsP3-gated calcium channels which activated by InsP3 and release calcium into plasma.
sdb:0117 ionotropic receptor on the ER  (Evidence:keywords,domains)
protein kinase-catalyzed phosphorylation of specific ion channel subunits lead to cell surface expression of ion channel subunit
sdb:0201 cell surface expression of ion channel subunit  (Evidence:keywords,domains)
activation of calmodulin-dependent protein kinases
sdb:0204 activation of calmodulin-dependent protein kinase  (Evidence:keywords,domains)
calcium-regulated transcription factor
sdb:0215 calcium-regulated transcription factor  (Evidence:keywords,domains)
calcium dependent short-term forms of presynaptic plasticity
sdb:0234 calcium dependent short-term forms of presynaptic plasticity  (Evidence:keywords,domains)
?
sdb:0265 cAMP mediated STP  (Evidence:keywords,domains)
intracellular calcium store release to change the concentration of cytosolic calcium.
sdb:0321 intracellular calcium store release  (Evidence:keywords,domains)
Calcium release from RyR (Ryanodine Receptor) in the SR (Sarcoplasmic Reticulum) is activated by the calcium induced-calcium-release
sdb:0325 RyR-CICR  (Evidence:keywords,domains)
KO assignmentK04963
  Level 3 annotation:
    ryanodine receptor 3 (brain)
  Level 2 annotation:
    Calcium signaling pathway
    Ion channels
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 46 residues, 31390454-31390589Exon2: 42 residues, 31552911-31553031Exon3: 38 residues, 31583123-31583231Exon4: 27 residues, 31610084-31610159Exon5: 28 residues, 31612803-31612882Exon6: 39 residues, 31618842-31618955Exon7: 35 residues, 31620283-31620383Exon8: 33 residues, 31623114-31623208Exon9: 27 residues, 31627622-31627697Exon10: 54 residues, 31629652-31629809Exon11: 60 residues, 31642329-31642503Exon12: 42 residues, 31646170-31646292Exon13: 58 residues, 31659468-31659637Exon14: 47 residues, 31661000-31661136Exon15: 34 residues, 31663887-31663983Exon16: 41 residues, 31665490-31665609Exon17: 46 residues, 31680911-31681045Exon18: 82 residues, 31682615-31682857Exon19: 66 residues, 31692675-31692868Exon20: 74 residues, 31703299-31703516Exon21: 37 residues, 31707963-31708068Exon22: 36 residues, 31709432-31709536Exon23: 30 residues, 31710702-31710786Exon24: 55 residues, 31712441-31712601Exon25: 51 residues, 31714078-31714226Exon26: 70 residues, 31715106-31715312Exon27: 60 residues, 31715868-31716043Exon28: 71 residues, 31723803-31724012Exon29: 60 residues, 31725843-31726019Exon30: 14 residues, 31726916-31726953Exon31: 56 residues, 31728564-31728728Exon32: 57 residues, 31732210-31732376Exon33: 31 residues, 31739212-31739299Exon34: 77 residues, 31739689-31739916Exon35: 267 residues, 31741645-31742441Exon36: 69 residues, 31743029-31743230Exon37: 36 residues, 31748846-31748949Exon38: 48 residues, 31749911-31750049Exon39: 93 residues, 31775710-31775984Exon40: 40 residues, 31777374-31777489Exon41: 45 residues, 31779196-31779326Exon42: 36 residues, 31780469-31780573Exon43: 47 residues, 31786411-31786547Exon44: 62 residues, 31802207-31802388Exon45: 39 residues, 31803557-31803669Exon46: 42 residues, 31805878-31805999Exon47: 58 residues, 31808349-31808519Exon48: 75 residues, 31810966-31811187Exon49: 32 residues, 31815727-31815818Exon50: 49 residues, 31817942-31818083Exon51: 56 residues, 31819324-31819488Exon52: 28 residues, 31821858-31821937Exon53: 32 residues, 31825560-31825650Exon54: 51 residues, 31827606-31827753Exon55: 23 residues, 31827960-31828023Exon56: 27 residues, 31829471-31829547Exon57: 43 residues, 31829655-31829779Exon58: 40 residues, 31834557-31834673Exon59: 24 residues, 31835798-31835866Exon60: 42 residues, 31836967-31837089Exon61: 18 residues, 31848150-31848200Exon62: 22 residues, 31848604-31848665Exon63: 81 residues, 31851412-31851651Exon64: 29 residues, 31853026-31853108Exon65: 45 residues, 31859703-31859834Exon66: 109 residues, 31865154-31865475Exon67: 82 residues, 31867710-31867951Exon68: 31 residues, 31880262-31880350Exon69: 33 residues, 31881361-31881454Exon70: 59 residues, 31889971-31890142Exon71: 22 residues, 31890470-31890530Exon72: 46 residues, 31892355-31892487Exon73: 39 residues, 31892959-31893072Exon74: 34 residues, 31896354-31896451Exon75: 37 residues, 31898070-31898177Exon76: 19 residues, 31899248-31899300Exon77: 21 residues, 31900248-31900305Exon78: 35 residues, 31900762-31900862Exon79: 28 residues, 31901015-31901095Exon80: 27 residues, 31902488-31902565Exon81: 26 residues, 31905095-31905169Exon82: 8 residues, 31905744-31905762Exon83: 29 residues, 31906164-31906245Exon84: 31 residues, 31906691-31906780Exon85: 45 residues, 31910455-31910584Exon86: 37 residues, 31914460-31914565Exon87: 29 residues, 31916398-31916480Exon88: 444 residues, 31917123-31918451Exon89: 21 residues, 31920317-31920376Exon90: 59 residues, 31921356-31921528Exon91: 31 residues, 31922980-31923067Exon92: 69 residues, 31924354-31924555Exon93: 45 residues, 31927783-31927914Exon94: 16 residues, 31932537-31932580Exon95: 44 residues, 31933047-31933175Exon96: 22 residues, 31933881-31933942Exon97: 51 residues, 31934258-31934405Exon98: 47 residues, 31937272-31937407Exon99: 54 residues, 31939067-31939224Exon100: 23 residues, 31940087-31940152Exon101: 35 residues, 31940570-31940671Exon102: 19 residues, 31943630-31943682Exon103: 325 residues, 31944623-31945594Exon104: 2 residues, -Jump to RYR3_HUMANExon1: 41 residues, 31390468-31390589Exon2: 42 residues, 31552911-31553031Exon3: 38 residues, 31583123-31583231Exon4: 27 residues, 31610084-31610159Exon5: 28 residues, 31612803-31612882Exon6: 39 residues, 31618842-31618955Exon7: 35 residues, 31620283-31620383Exon8: 33 residues, 31623114-31623208Exon9: 27 residues, 31627622-31627697Exon10: 54 residues, 31629652-31629809Exon11: 60 residues, 31642329-31642503Exon12: 42 residues, 31646170-31646292Exon13: 58 residues, 31659468-31659637Exon14: 47 residues, 31661000-31661136Exon15: 34 residues, 31663887-31663983Exon16: 41 residues, 31665490-31665609Exon17: 46 residues, 31680911-31681045Exon18: 82 residues, 31682615-31682857Exon19: 66 residues, 31692675-31692868Exon20: 74 residues, 31703299-31703516Exon21: 37 residues, 31707963-31708068Exon22: 36 residues, 31709432-31709536Exon23: 30 residues, 31710702-31710786Exon24: 55 residues, 31712441-31712601Exon25: 51 residues, 31714078-31714226Exon26: 70 residues, 31715106-31715312Exon27: 60 residues, 31715868-31716043Exon28: 71 residues, 31723803-31724012Exon29: 60 residues, 31725843-31726019Exon30: 14 residues, 31726916-31726953Exon31: 56 residues, 31728564-31728728Exon32: 57 residues, 31732210-31732376Exon33: 31 residues, 31739212-31739299Exon34: 77 residues, 31739689-31739916Exon35: 267 residues, 31741645-31742441Exon36: 69 residues, 31743029-31743230Exon37: 36 residues, 31748846-31748949Exon38: 48 residues, 31749911-31750049Exon39: 93 residues, 31775710-31775984Exon40: 40 residues, 31777374-31777489Exon41: 45 residues, 31779196-31779326Exon42: 36 residues, 31780469-31780573Exon43: 47 residues, 31786411-31786547Exon44: 62 residues, 31802207-31802388Exon45: 39 residues, 31803557-31803669Exon46: 42 residues, 31805878-31805999Exon47: 58 residues, 31808349-31808519Exon48: 75 residues, 31810966-31811187Exon49: 32 residues, 31815727-31815818Exon50: 49 residues, 31817942-31818083Exon51: 56 residues, 31819324-31819488Exon52: 28 residues, 31821858-31821937Exon53: 32 residues, 31825560-31825650Exon54: 51 residues, 31827606-31827753Exon55: 23 residues, 31827960-31828023Exon56: 27 residues, 31829471-31829547Exon57: 43 residues, 31829655-31829779Exon58: 40 residues, 31834557-31834673Exon59: 24 residues, 31835798-31835866Exon60: 42 residues, 31836967-31837089Exon61: 18 residues, 31848150-31848200Exon62: 22 residues, 31848604-31848665Exon63: 81 residues, 31851412-31851651Exon64: 29 residues, 31853026-31853108Exon65: 45 residues, 31859703-31859834Exon66: 109 residues, 31865154-31865475Exon67: 82 residues, 31867710-31867951Exon68: 31 residues, 31880262-31880350Exon69: 33 residues, 31881361-31881454Exon70: 7 residues, 31887047-31887062Exon71: 59 residues, 31889971-31890142Exon72: 22 residues, 31890470-31890530Exon73: 46 residues, 31892355-31892487Exon74: 39 residues, 31892959-31893072Exon75: 34 residues, 31896354-31896451Exon76: 37 residues, 31898070-31898177Exon77: 19 residues, 31899248-31899300Exon78: 21 residues, 31900248-31900305Exon79: 35 residues, 31900762-31900862Exon80: 28 residues, 31901015-31901095Exon81: 27 residues, 31902488-31902565Exon82: 26 residues, 31905095-31905169Exon83: 8 residues, 31905744-31905762Exon84: 29 residues, 31906164-31906245Exon85: 31 residues, 31906691-31906780Exon86: 45 residues, 31910455-31910584Exon87: 37 residues, 31914460-31914565Exon88: 29 residues, 31916398-31916480Exon89: 444 residues, 31917123-31918451Exon90: 21 residues, 31920317-31920376Exon91: 59 residues, 31921356-31921528Exon92: 31 residues, 31922980-31923067Exon93: 69 residues, 31924354-31924555Exon94: 45 residues, 31927783-31927914Exon95: 16 residues, 31932537-31932580Exon96: 44 residues, 31933047-31933175Exon97: 22 residues, 31933881-31933942Exon98: 51 residues, 31934258-31934405Exon99: 47 residues, 31937272-31937407Exon100: 54 residues, 31939067-31939224Exon101: 23 residues, 31940087-31940152Exon102: 35 residues, 31940570-31940671Exon103: 19 residues, 31943630-31943682Exon104: 325 residues, 31944623-31945594Exon105: 2 residues, -Jump to RYR3_HUMAN  
Tune and view alternative isoforms