SynDB Home Page
SynDB Home Page
Browse
Search
Download
Help
People
links

blue bulletSynDB protein details  


Parse error: syntax error, unexpected T_VARIABLE in /home/kongl/syndb/www/sdb_nats.php on line 52
0RTN4_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameRTN4
DescriptionReticulon-4 (neurite outgrowth inhibitor) (nogo protein) (foocen) (neuroendocrine-specific protein) (nsp) (neuroendocrine specific protein c homolog) (rtn-x) (reticulon 5).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005783 endoplasmic reticulum (NAS)
0030176 integral to endoplasmic reticulum membrane (IEP)
0005635 nuclear membrane (IDA)
0005515 protein binding (IPI)
0019987 negative regulation of anti-apoptosis (IMP)
0030517 negative regulation of axon extension (IDA)
0042981 regulation of apoptosis (NAS)

Warning: fopen(/home/kongl/syndb/www/temp/815310184.dot) [function.fopen]: failed to open stream: Permission denied in /home/kongl/syndb/www/sdb_pro.php on line 269

Warning: fwrite(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 270

Warning: fwrite(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 271

Warning: fwrite(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 272

Warning: fwrite(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 273

Warning: fwrite(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 274

Warning: fwrite(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 299

Warning: fclose(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 300
schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
Eukaryotic proteins of the reticulon (RTN) family all share an association with the endoplasmic reticulum (ER). Whereas amino-terminal regions are not related to one another.ll reticulon proteins share a 200 amino acid residue region of sequence similarity at the C-terminal. This region contains twolarge hydrophobic regions separated by a 66 residue hydrophilic segment. Theconserved hydrophobic C-terminal portion has been shown to play an essentialrole in the association of reticulons with the ER membrane. The hydrophobicportions are supposed to be membrane-embedded and the hydrophilic 66 residuelocalized to the lumenal/extracellular face of the membrane. Most reticulonshave a di-lysine ER retention motif at the C-terminal. Because of their likelyassociation with the rough as well as the smooth ER.he reticulons might playsome role in transport processes or in regulation of intracellular calciumlevels. It has been suggested that the reticulons may be serving as ER-associated channel-like complexes .
  IPR003388:Reticulon
IPR003388:Reticulon 
Evalue:-107.229148864746 
Location:1005-1190IPR003388:Reticulon 
Evalue:0 
Location:86-490
SequencesProtein: RTN4_HUMAN (1192 aa)
mRNA: NM_020532
Local Annotation
Synapse Ontology
mitochondria are frequently observed in the vicinity of the synaptic vesicle clusters, in agreement with the ATP requirement of several steps of the vesicle cycle.
sdb:0118 mitochondria  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 336 residues, 55052832-55053838Exon2: 21 residues, 55054202-55054261Exon3: 17 residues, 55054460-55054507Exon4: 25 residues, 55055334-55055404Exon5: 48 residues, 55063154-55063293Exon6: 71 residues, 55068130-55068338Exon7: 802 residues, 55105725-55108125Exon8: 21 residues, 55108803-55108860Exon9: 286 residues, 55130384-55131238Exon10: 2 residues, -Jump to RTN4_HUMAN  
Tune and view alternative isoforms
Loci Cluster (Details)Loci: 4442 55317261-55349819 ~-33K 20457(MTIF2)(-)Loci: 4441 55052832-55131238 ~-78K 20448(RTN4)(-)Link out to UCSC