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0RT27_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
DescriptionMitochondrial 28s ribosomal protein s27 (s27mt) (mrp-s27).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
Domain Architecture (Details)
InterPro domains unassigned to SynO:
Pentatricopeptide repeat proteins are characterised by the presence of a tandem array of the number of PPR motifs controls the affinity and specificity of the PPR protein for RNA. These proteins occur predominantly in they appear to play essential roles in RNA/DNA metabolism in mitochondria and chloroplasts . It has been suggested that each of the highly variable PPR proteins is a gene-specific regulator of plant organellar RNA metabolism. PPR proteins may also play a role in organelle biogenesis.robably via binding to organellar transcripts . Examples of PPR repeat-containing proteins include PET309 .hich may be involved in RNA stabilisation .nd crp1.hich is involved in RNA processing . The repeat is associated with a predicted plant protein that has a domain organization similar to the human BRCA1 protein.
  IPR002885:Pentatricopeptide repeat
Protein prenyltransferases catalyze the transfer of the carbon moiety of C15 farnesyl pyrophosphate or geranylgeranyl pyrophosphate synthase to a conserved cysteine residue in a CaaX motif of protein and peptide substrates. The addition of a farnesyl group is required to anchor proteins to the cell membrane. In the 3D structure of a mammalian Ras farnesyltransferases (Ftase).oth subunits are largely composed of alpha-helices. The alpha-2 to alpha-15 helices in the alpha subunit fold into a novel helical hairpin structure.esulting in a crescent-shape domain that envelopes part of the subunit. The 12 helices of the beta-subunit form an alpha-alpha barrel. Six additional helices connect the inner core of helices and form the outside of the helical barrel. A deep cleft surrounded by hydrophobic amino acids in the centre of the barrel is proposed as the FPP-binding pocket. A single Zn2+ ion is located at the junction between the hydrophilic surface groove near the subunit interface. The SSF signature in this entry is currently under review. Please be aware that some of the protein hits may be false positives.
  IPR008940:Protein prenyltransferase
SequencesProtein: RT27_HUMAN (414 aa)
mRNA: NM_015084
Local Annotation
Synapse Ontology
mitochondria are frequently observed in the vicinity of the synaptic vesicle clusters, in agreement with the ATP requirement of several steps of the vesicle cycle.
sdb:0118 mitochondria  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 541 residues, 71551111-71552731Exon2: 58 residues, 71555265-71555433Exon3: 49 residues, 71557639-71557782Exon4: 36 residues, 71559848-71559951Exon5: 40 residues, 71564025-71564141Exon6: 28 residues, 71565701-71565780Exon7: 40 residues, 71569596-71569711Exon8: 21 residues, 71627113-71627172Exon9: 25 residues, 71629214-71629285Exon10: 28 residues, 71645663-71645741Exon11: 28 residues, 71651731-71651809Exon12: 2 residues, -Jump to RT27_HUMAN  
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Loci Cluster (Details)Loci: 3464 71050749-71052628 ~-2K 28983(CART)(+)Loci: 3465 71438890-71538608 ~-100K 28984(MAP1B)(+)Loci: 4717 71551111-71651809 ~-101K 28987(MRPS27)(-)Loci: 3463 70918909-70988981 ~-70K 28982(MCCC2)(+)Link out to UCSC