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0RT18C_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
Description28s ribosomal protein s18c, mitochondrial precursor (mrp-s18-c) (mrps18c) (mrp-s18-1).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005763 mitochondrial small ribosomal subunit (IDA)
0003735 structural constituent of ribosome (NAS)
0006412 protein biosynthesis (NAS)

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Domain Architecture (Details)
InterPro domains unassigned to SynO:
Ribosomes are the particles that catalyze mRNA-directed protein synthesis in all organisms. The codons of the mRNA are exposed on the ribosome to allow tRNA binding. This leads to the incorporation of amino acids into the growing polypeptide chain in accordance with the genetic information. Incoming amino acid monomers enter the ribosomal A site in the form of aminoacyl-tRNAs complexed with elongation factor Tu (EF-Tu) and GTP. The growing polypeptide chain.ituated in the P site as peptidyl-tRNA.s then transferred to aminoacyl-tRNA and the new peptidyl-tRNA.xtended by one residue.s translocated to the P site with the aid the elongation factor G (EF-G) and GTP as the deacylated tRNA is released from the ribosome through one or more exit sites . About 2/3 of the mass of the ribosome consists of RNA and 1/3 of protein. The proteins are named in accordance with the subunit of the ribosome which they belong to - the small (S1 to S31) and the large (L1 to L44). Usually they decorate the rRNA cores of the subunits. Many of ribosomal proteins.articularly those of the large composed of a globular.urfaced-exposed domain with long finger-like projections that extend into the rRNA core to stabilize its structure. Most of the proteins interact with multiple RNA elements.ften from different domains. In the large subunit.bout 1/3 of the 23S rRNA nucleotides are at least in van der Waals contact with protein.nd L22 interacts with all six domains of the 23S rRNA. Proteins S4 and S7.hich initiate assembly of the 16S located at junctions of five and four RNA helices.espectively. In this way proteins serve to organize and stabilize the rRNA tertiary structure. While the crucial activities of decoding and peptide transfer are RNA based.roteins play an active role in functions that may have evolved to streamline the process of protein synthesis. In addition to their function in the ribosome.any ribosomal proteins have some function outside the ribosome .Evidence suggests that.n prokaryotes.he peptidyl transferase reaction is performed by the large subunit 23S rRNA.hereas proteins probably have a greater role in eukaryotic ribosomes. Most of the proteins lie close to.r on the surface of.he 30S subunit.rranged peripherally around the rRNA . The small subunit ribosomal proteins can be categorised as primary binding proteins.hich bind directly and independently to 16S rRNA; secondary binding proteins.hich display no specific affinity for 16S rRNA.ut its assembly is contingent upon the presence of one or more primary binding proteins; and tertiary binding proteins.hich require the presence of one or more secondary binding proteins and sometimes other tertiary binding proteins.The small ribosomal subunit protein S18 is known to be involved in binding the aminoacyl-tRNA complex in Escherichia coli .nd appears to be situated at the tRNA A-site. Experimental evidence has revealed that S18 is well exposed on the surface of the E. coli ribosome.nd is a secondary rRNA binding protein . S18 belongs to a family of ribosomal proteins that includes: eubacterial S18; metazoan mitochondrial S18.lgal and plant chloroplast S18; and cyanelle S18.
  IPR001648:Ribosomal protein S18
SequencesProtein: RT18C_HUMAN (142 aa)
mRNA: NM_016067
Local Annotation
Synapse Ontology
mitochondria are frequently observed in the vicinity of the synaptic vesicle clusters, in agreement with the ATP requirement of several steps of the vesicle cycle.
sdb:0118 mitochondria  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 54 residues, 84596195-84596354Exon2: 18 residues, 84597085-84597135Exon3: 30 residues, 84598522-84598606Exon4: 21 residues, 84599916-84599974Exon5: 22 residues, 84601149-84601209Exon6: 203 residues, 84601297-84601900Exon7: 2 residues, -Jump to RT18C_HUMAN  
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Loci Cluster (Details)Loci: 3419 84596195-84601900 ~-6K 27854(MRPS18C)(+)Loci: 3418 84175262-84215994 ~-41K 27843(COPS4)(+)Link out to UCSC