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0RT06_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameMRPS6
DescriptionMitochondrial 28s ribosomal protein s6 (s6mt) (mrp-s6).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0015935 small ribosomal subunit (NAS)
0003735 structural constituent of ribosome (NAS)
0006412 protein biosynthesis (NAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
Ribosomes are the particles that catalyze mRNA-directed protein synthesis in all organisms. The codons of the mRNA are exposed on the ribosome to allow tRNA binding. This leads to the incorporation of amino acids into the growing polypeptide chain in accordance with the genetic information. Incoming amino acid monomers enter the ribosomal A site in the form of aminoacyl-tRNAs complexed with elongation factor Tu (EF-Tu) and GTP. The growing polypeptide chain.ituated in the P site as peptidyl-tRNA.s then transferred to aminoacyl-tRNA and the new peptidyl-tRNA.xtended by one residue.s translocated to the P site with the aid the elongation factor G (EF-G) and GTP as the deacylated tRNA is released from the ribosome through one or more exit sites . About 2/3 of the mass of the ribosome consists of RNA and 1/3 of protein. The proteins are named in accordance with the subunit of the ribosome which they belong to - the small (S1 to S31) and the large (L1 to L44). Usually they decorate the rRNA cores of the subunits. Many of ribosomal proteins.articularly those of the large subunit.re composed of a globular.urfaced-exposed domain with long finger-like projections that extend into the rRNA core to stabilize its structure. Most of the proteins interact with multiple RNA elements.ften from different domains. In the large subunit.bout 1/3 of the 23S rRNA nucleotides are at least in van der Waals contact with protein.nd L22 interacts with all six domains of the 23S rRNA. Proteins S4 and S7.hich initiate assembly of the 16S rRNA.re located at junctions of five and four RNA helices.espectively. In this way proteins serve to organize and stabilize the rRNA tertiary structure. While the crucial activities of decoding and peptide transfer are RNA based.roteins play an active role in functions that may have evolved to streamline the process of protein synthesis. In addition to their function in the ribosome.any ribosomal proteins have some function outside the ribosome .Ribosomal protein S6 is one of the proteins from the small ribosomal subunit. In Escherichia coli.6 is known to bind together with S18 to 16S ribosomal RNA. It belongs to a family of ribosomal proteins which.n the basis of sequence similarities.roups bacterial.ed algal chloroplast and cyanelle S6 ribosomal proteins.
  IPR000529:Ribosomal protein S6
IPR000529:S6 
Evalue:0 
Location:1-97IPR000529:RIBOSOMAL_S6 
Evalue:0 
Location:0-0
SequencesProtein: RT06_HUMAN (124 aa)
mRNA: NM_032476
Local Annotation
Synapse Ontology
mitochondria are frequently observed in the vicinity of the synaptic vesicle clusters, in agreement with the ATP requirement of several steps of the vesicle cycle.
sdb:0118 mitochondria  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 75 residues, 34367692-34367915Exon2: 48 residues, 34419510-34419650Exon3: 209 residues, 34436577-34437198Exon4: 2 residues, -Jump to RT06_HUMAN  
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Loci Cluster (Details)Loci: 4549 34197627-34210028 ~-12K 23791(ATP5O)(-)Loci: 3287 34367692-34437198 ~-70K 23793(MRPS6)(+)Loci: 3286 33936653-34183479 ~-247K 23790(ITSN1)(+)Link out to UCSC