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0RPTOR_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameRAPTOR
DescriptionRegulatory associated protein of mtor (raptor) (p150 target of rapamycin (tor)-scaffold protein).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GON/A
Domain Architecture (Details)
InterPro domains unassigned to SynO:
The HEAT repeat is a tandemly repeated.7-47 amino acid long moduleoccurring in a number of cytoplasmic proteins.ncluding the fourname-giving proteins huntingtin.longation factor 3 (EF3).he 65 Kdalpha regulatory subunit of protein phosphatase 2A (PP2A) and theyeast PI3-kinase TOR1 . Arrays of HEAT repeats consists of 3 to 36units forming a rod-like helical structure and appear to function as protein-protein interaction surfaces. It has been noted that manyHEAT repeat-containing proteins are involved in intracellular transport processes.In the crystal structure of PP2A PR65/A .he HEAT repeats consistof pairs of antiparallel alpha helices.s predicted in .
  IPR000357:HEAT
WD-40 repeats (also known as WD or beta-transducin repeats) are short ~40 amino acid motifs.ften terminating in a Trp-Asp (W-D) dipeptide. WD-containing proteins have 4 to 16 repeating units.ll of which are thought to form a circularised beta-propeller structure. WD-repeat proteins are a large family found in all eukaryotes and are implicated in a variety of functions ranging from signal transduction and transcription regulation to cell cycle control and apoptosis. The underlying common function of all WD-repeat proteins is coordinating multi-protein complex assemblies.here the repeating units serve as a rigid scaffold for protein interactions. The specificity of the proteins is determined by the sequences outside the repeats themselves. Examples of such complexes are G proteins (beta subunit is a beta-propeller).AFII transcription factor.nd E3 ubiquitin ligase .
  IPR001680:WD-40 repeat
This family consists of Raptor (regulatory associated protein of TOR) and its orthologs which includes Kog1p of Saccharomyces cerevisiae. highly conserved 150-kDa TOR-binding protein . The target-of-rapamycin (TOR) proteins are protein kinases that were first identified in S. cerevisiae through mutants that conferred resistance to growth inhibition induced by the immunosuppressive macrolide rapamycin.All Raptor orthologs contain a unique conserved region in their N-terminal half (raptor N-terminal conserved.lso called the RNC domain) followed by three HEAT (huntingtin.longation factor 3. subunit of protein phosphatase 2A and TOR1) repeats and seven WD-40 repeats near the C terminus. Research on mammalian Raptor suggests that its association with mTOR promotes the phosphorylation of downstream effectors in nutrient-stimulated cells . In concordance with these observations.he binding of TOR to Raptor or to Kog1p is necessary for TOR signalling in vivo in Caenorhabditis elegans and S. cerevisiae .The RNC domain consists of 3 blocks with at least 67 to 79% sequence similarity and is predicted to have a high propensity to form alpha helices. The RNC domain is characterised by the presence of invariant catalytic Cys-His dyad.hich is structurally and evolutionarily related to known caspases.uggesting that the raptor proteins may have protease activity .
  IPR004083:Regulatory associated protein of TOR
The WD40 motif is found in a multitude of eukaryotic proteins involved in a variety of cellular processes . Repeated WD40 motifs act as a site for protein-protein interaction.nd proteins containing WD40 repeats are known to serve as platforms for the assembly of protein complexes or mediators of transient interplay among other proteins. In Arabidopsis sp..everal WD40-containig proteins act as key regulators of plant-specific developmental events. WD40 repeats usually assume a 7-8 bladed beta-propeller fold.ut proteins have been found with 4 to 16 repeated units.The structures of several WD40 repeat-containing proteins have been determined.ncluding the beta-1 subunit of the signal-transducing G protein heterotrimer.he C-terminal domain of yeast Tup1.he C-terminal domain of Groucho/tle1.he Cdc4 propeller domain.he bovine Arp2/3 complex 41 kDa subunit ARPC1.nd actin interacting protein 1. The SSF signature in this entry is currently under review. Please be aware that some of the protein hits may be false positives.
  IPR011046:WD40-like
This domain consists of a multi-helical fold comprised of two curved layers of alpha helices arranged in a regular right-handed superhelix.here the repeats that make up this structure are arranged about a common axis . These superhelical structures present an extensive solvent-accessible surface that is well suited to binding large substrates such as proteins and nucleic acids. This topology has been found with a number of repeats and domains.ncluding the armadillo repeat (found in beta-catenins and importins).he HEAT repeat (found in protein phosphatase 2a and initiation factor eIF4G).he PHAT domain (found in Smaug RNA-binding protein).he leucine-rich repeat variant.he Pumilo repeat.nd in the H regulatory subunit of V-type ATPases. The sequence similarity among these different repeats or domains is low.owever they exhibit considerable structural similarity. Furthermore.he number of repeats present in the superhelical structure can vary between orthologues.ndicating that rapid loss/gain of repeats has occurred frequently in evolution. A common phylogenetic origin has been proposed for the armadillo and HEAT repeats .
  IPR011989:Armadillo-like helical
IPR000357:HEAT 
Evalue:-3.698970079422 
Location:551-588IPR001680:WD40 
Evalue:-3.63827204704285 
Location:1156-1194IPR001680:WD40 
Evalue:-3.60206007957458 
Location:1302-1329IPR000357:HEAT 
Evalue:-3.21467018127441 
Location:598-630IPR001680:WD40 
Evalue:-1.82390868663788 
Location:1201-1240IPR001680:WD40 
Evalue:-1.56863617897034 
Location:1079-1097IPR000357:HEAT 
Evalue:-0.173925191164017 
Location:805-841IPR011046:WD40_like 
Evalue:0 
Location:2-35IPR004083:YEAST176DUF 
Evalue:0 
Location:408-438IPR004083:YEAST176DUF 
Evalue:0 
Location:298-325IPR004083:YEAST176DUF 
Evalue:0 
Location:144-169IPR004083:YEAST176DUF 
Evalue:0 
Location:333-357IPR004083:YEAST176DUF 
Evalue:0 
Location:171-195IPR004083:YEAST176DUF 
Evalue:0 
Location:439-460IPR004083:YEAST176DUF 
Evalue:0 
Location:53-74IPR004083:YEAST176DUF 
Evalue:0 
Location:118-139IPR004083:YEAST176DUF 
Evalue:0 
Location:258-278IPR004083:YEAST176DUF 
Evalue:0 
Location:97-116IPR004083:YEAST176DUF 
Evalue:0 
Location:462-481IPR004083:YEAST176DUF 
Evalue:0 
Location:486-502IPR001680:WD_REPEATS_2 
Evalue:0 
Location:0-0IPR001680:WD40 
Evalue:0.838849090737255 
Location:1246-1281IPR001680:WD40 
Evalue:1.39794000867204 
Location:1012-1050IPR001680:WD40 
Evalue:2.25527250510331 
Location:1105-1151
SequencesProtein: RPTOR_HUMAN (1335 aa)
mRNA: NM_020761
Local Annotation
Synapse Ontology
A process that increases long-term neuronal synaptic plasticity, the ability of neuronal synapses to change long-term as circumstances require. Long-term neuronal synaptic plasticity generally involves increase or decrease in actual synapse numbers.
sdb:0039 positive regulation of long-term neuronal synaptic plasticity  (Evidence:keywords)
KO assignmentK07204
  Level 3 annotation:
    regulatory associated protein of mTOR
  Level 2 annotation:
    Insulin signaling pathway
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 175 residues, 76133662-76134186Exon2: 36 residues, 76214085-76214188Exon3: 29 residues, 76232122-76232205Exon4: 55 residues, 76296235-76296394Exon5: 51 residues, 76318954-76319101Exon6: 60 residues, 76342404-76342580Exon7: 22 residues, 76379844-76379904Exon8: 35 residues, 76410595-76410696Exon9: 50 residues, 76411473-76411618Exon10: 27 residues, 76426316-76426392Exon11: 36 residues, 76434867-76434969Exon12: 30 residues, 76443858-76443942Exon13: 39 residues, 76446184-76446295Exon14: 27 residues, 76468809-76468884Exon15: 24 residues, 76471813-76471879Exon16: 66 residues, 76472175-76472367Exon17: 49 residues, 76473402-76473543Exon18: 41 residues, 76480114-76480232Exon19: 49 residues, 76481123-76481264Exon20: 55 residues, 76482101-76482260Exon21: 41 residues, 76497205-76497324Exon22: 36 residues, 76511118-76511222Exon23: 63 residues, 76511884-76512068Exon24: 39 residues, 76513764-76513875Exon25: 37 residues, 76528890-76528996Exon26: 40 residues, 76534061-76534176Exon27: 43 residues, 76535621-76535746Exon28: 37 residues, 76537837-76537942Exon29: 37 residues, 76546018-76546125Exon30: 44 residues, 76548472-76548600Exon31: 31 residues, 76549788-76549875Exon32: 41 residues, 76550855-76550972Exon33: 45 residues, 76551322-76551452Exon34: 704 residues, 76552656-76554762Exon35: 2 residues, -Jump to RPTOR_HUMAN  
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