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0RPOM_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NamePOLRMT
DescriptionDna-directed rna polymerase, mitochondrial precursor (ec 2.7.7.6) (mtrpol).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005739 mitochondrion (TAS)
Domain Architecture (Details)
InterPro domains unassigned to SynO:
DNA-dependent RNA polymerases () areresponsible for the polymerisation of ribonucleotidesinto a sequence complementary to the template DNA. Ineukaryotes.here are three different forms ofDNA-dependent RNA polymerases transcribing differentsets of genes. Most RNA polymerases are multimericenzymes and are composed of a variable number ofsubunits. RNA synthesis follows after the attachmentof RNA polymerase to a specific site.he promoter.nthe template DNA strand. The RNA synthesis processcontinues until a termination sequence is reached. The RNA product.hich is synthesised in the 5 to 3direction.s known as the primary transcript.Eukaryotic nuclei contain three distinct types of RNApolymerases that differ in the RNA they synthesise: RNA polymerase I: located in the nucleoli.ynthesises precursors of most ribosomal RNAs. RNA polymerase II: occurs in the nucleoplasm.ynthesises mRNA precursors. RNA polymerase III: also occurs in the nucleoplasm.ynthesises the precursors of 5S ribosomal RNA.hetRNAs.nd a variety of other small nuclear andcytosolic RNAs. Eukaryotic cells are also known to contain separatemitochondrial and chloroplast RNA polymerases. Eukaryotic RNA polymerases.hose molecular massesvary in size from 500 to 700 kD.ontain twonon-identical large (>100 kDa) subunits and an arrayof up to 12 different small (less than 50 kDa) subunits. This is a family of single chain polymerases.hich are evolutionary related.nd which originate from bacteriophage or from mitochondria .
  IPR002092:DNA-directed RNA polymerase, bacteriophage type
Pentatricopeptide repeat proteins are characterised by the presence of a tandem array of repeats.here the number of PPR motifs controls the affinity and specificity of the PPR protein for RNA. These proteins occur predominantly in plants.here they appear to play essential roles in RNA/DNA metabolism in mitochondria and chloroplasts . It has been suggested that each of the highly variable PPR proteins is a gene-specific regulator of plant organellar RNA metabolism. PPR proteins may also play a role in organelle biogenesis.robably via binding to organellar transcripts . Examples of PPR repeat-containing proteins include PET309 .hich may be involved in RNA stabilisation .nd crp1.hich is involved in RNA processing . The repeat is associated with a predicted plant protein that has a domain organization similar to the human BRCA1 protein.
  IPR002885:Pentatricopeptide repeat
IPR002092:RNA_pol 
Evalue:-205.327896118164 
Location:830-1230IPR002885:PPR 
Evalue:0 
Location:262-296
SequencesProtein: RPOM_HUMAN (1230 aa)
mRNA: NM_005035
Local Annotation
Synapse Ontology
mitochondria are frequently observed in the vicinity of the synaptic vesicle clusters, in agreement with the ATP requirement of several steps of the vesicle cycle.
sdb:0118 mitochondria  (Evidence:keywords)
KO assignmentK00960
  Level 3 annotation:
    DNA-directed RNA polymerase
  Level 2 annotation:
    RNA polymerase
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 34 residues, 568224-568323Exon2: 22 residues, 568418-568480Exon3: 30 residues, 568569-568655Exon4: 26 residues, 568776-568849Exon5: 35 residues, 569487-569586Exon6: 20 residues, 569704-569760Exon7: 40 residues, 569996-570110Exon8: 31 residues, 570209-570296Exon9: 62 residues, 570585-570765Exon10: 43 residues, 570957-571080Exon11: 43 residues, 571364-571487Exon12: 265 residues, 572057-572846Exon13: 77 residues, 573148-573373Exon14: 59 residues, 573581-573752Exon15: 57 residues, 573820-573985Exon16: 52 residues, 574453-574603Exon17: 64 residues, 575718-575905Exon18: 45 residues, 576123-576254Exon19: 211 residues, 580539-581168Exon20: 37 residues, 583833-583938Exon21: 37 residues, 584424-584530Exon22: 2 residues, -Jump to RPOM_HUMAN  
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Loci Cluster (Details)Loci: 4349 568224-584530 ~-16K 17494(POLRMT)(-)Loci: 3077 868357-872013 ~-4K 17519(GPR54)(+)Loci: 3078 951436-960723 ~-9K 17523(GRIN3B)(+)Loci: 3079 1192748-1195823 ~-3K 17537(ATP5D)(+)Loci: 3080 1334888-1346583 ~-12K 17550(+)Loci: 4350 1766247-1799450 ~-33K 17579(-)Loci: 4351 1988469-2002233 ~-14K 17594(MKNK2)(-)Loci: 4352 2051987-2102554 ~-51K 17601(AP3D1)(-)Loci: 3076 540892-568157 ~-27K 17493(HCN2)(+)Link out to UCSC