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0ROM1_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
DescriptionRod outer segment membrane protein 1 (rosp1) (tetraspanin-23) (tspan- 23).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005887 integral to plasma membrane (TAS)
0007601 visual perception (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
A number of eukaryotic CD antigens have been shown to be related. CD9 (also called DRAP-27.RP-1 or p24) upregulates HB-EGF activity as a receptor for diphtheria toxin as well as its juxtacrine activity. CD9 mAbs modulate cell adhesion and migration and trigger platelet activation that is blocked by mAbs directed to the platelet Fc receptor CD32. In mice.D9 mAb KMC8.8 has been shown to inhibit the production of myeloid cells in vitro and has a costimulatory activity for T cells. CD9 is a type III membrane protein.ith four putative transmembrane domains. CD37 (or gp52-40) is involved in signal transduction and serves as a stable marker for malignancies derived from mature B cells.ike B-CLL.CL.nd all types of B-NHL. CD63 transfection reduced melanoma cell motility on fibronectin.ollagen and laminin.nd reduced the growth and metastasis of melanoma cells in nude mice . CD63 has been used as a marker for late endosomes and for primary melanomas.These proteins are all type II membrane proteins: they contain anN-terminal transmembrane (TM) domain.hich acts both as a signal sequenceand a membrane anchor.nd 3 additional TM regions (hence the name TM4).The sequences contain a number of conserved cysteine residues.CD molecules are leucocyte antigens on cell surfaces. CD antigens nomenclature is updated at
  IPR000301:CD9/CD37/CD63 antigen
The outer segments of vertebrate rod photoreceptor cells are specialised organelles that function in the transduction of light into electrical signals as part of the visual excitation process. These organelles contain thousands of closely-stacked disk membranes.hich have distinctly different protein compositions in their lamellar and rim regions . Peripherin (or RDS) and rom-1 are related retinal-specific integral membrane proteins which are located at the rims of the photoreceptor they may act jointly in disk morphogenesis . Both peripherin and rom-1 formdisulphide-linked homodimers. Defects in the peripherin gene (RDS) cause various human diseases such asautosomal dominant retinitis pigmentosa.utosomal dominant punctata albescens and butterfly-shaped pigment dystrophy. In mice it causes retinopathy known as retinal degeneration slow (rds). These proteins contain about 350 amino acid residues. Structurally they consist of a short cytoplasmic N-terminal domain.ollowed by four transmembrane segments that delimit two lumenal and one cytoplasmic loops; the C-terminal domain is cytoplasmic. The second lumenal loop is very large (about 140 amino acid residues) and contains seven conserved cysteines.
Tetraspanins are a distinct family of proteins.ontaining four transmembrane domains: a small outer loop (EC1). larger outer loop (EC2). small inner loop (IL) and short cytoplasmic tails. They contain characteristic structural features.ncluding 4-6 conserved extracellular cysteine residues.nd polar residues within transmembrane domains. A fundamental role of tetraspanins appears to be organizing other proteins into a network of multimolecular membrane microdomains.ometimes called the tetraspanin web. Within this web there are primary complexes in which tetraspanins show robust.pecific.nd direct lateral associations with other proteins. The strong tendency of tetraspanins to associate with each other probably contributes to the assembly of a network of secondary interactions in which non-tetraspanin proteins are associated with each other via palmitoylated tetraspanins acting as linker proteins. In addition.he association of lipids.uch as gangliosides and cholesterol.robably contributes to the assembly of even larger tetraspanin complexes.hich have some lipid raft-like properties (e.g. resistance to solubilization in non-ionic detergents). Within the tetraspanin web.etraspanin proteins can associate not only with integrins and other transmembrane proteins.ut also with signalling enzymes such as protein kinase C and phosphatidylinositol-4 kinase. Thus.he tetraspanin web provides a mechanistic framework by which membrane protein signalling can be expanded into a lateral dimension . The tetraspanin domain consists of 5 helices in an irregular disulphide-linked array which plays a role in form homodimerization.The SSF signature in this entry is currently under review. Please be aware that some of the protein hits may be false positives.
SequencesProtein: ROM1_HUMAN (351 aa)
mRNA: NM_000327
Local Annotation
Synapse Ontology
the mechanism by which the restiong potential is held.
sdb:0288 maintain membrane potential  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 241 residues, 62137198-62137919Exon2: 84 residues, 62138305-62138552Exon3: 166 residues, 62138668-62139162Exon4: 2 residues, -Jump to ROM1_HUMAN  
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Loci Cluster (Details)Loci: 2668 62137198-62139162 ~-2K 6915(ROM1)(+)Loci: 3955 62148876-62170680 ~-22K 6917(GANAB)(-)Loci: 2669 62252159-62262681 ~-11K 6930(+)Loci: 3956 62330945-62356116 ~-25K 6938(STX5A)(-)Loci: 2670 62380093-62412928 ~-33K 6943(SLC3A2)(+)Loci: 3957 62432727-62445588 ~-13K 6949(CHRM1)(-)Loci: 3954 62117250-62125879 ~-9K 6910(MTA2)(-)Link out to UCSC