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0RNPC2_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameRNPC2
DescriptionRna-binding region containing protein 2 (hepatocellular carcinoma protein 1) (splicing factor hcc1).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005654 nucleoplasm (TAS)
0006396 RNA processing (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
Many eukaryotic proteins that are known or supposed to bind single-stranded RNA contain one or more copies of a putative RNA-binding domain of about 90 amino acids. This is known as the eukaryotic putative RNA-binding region RNP-1 signature or RNA recognition motif (RRM). RRMs are found in a variety of RNA binding proteins.ncluding heterogeneous nuclear ribonucleoproteins (hnRNPs).roteins implicated in regulation of alternative splicing.nd protein components of small nuclear ribonucleoproteins (snRNPs). The RRM in heterodimeric splicing factor U2 snRNP auxiliary factor (U2AF) appears to have two RRM-like domains with specialized features for protein recognition . The motif also appears in a few single stranded DNA binding proteins. The RRM structure consists of four strands and two helices arranged in an alpha/beta sandwich.ith a third helix present during RNA binding in some cases .
  IPR000504:RNA-binding region RNP-1 (RNA recognition motif)
These sequences represent a subfamily of RNA splicing factors including the Pad-1 protein (Neurospora crassa).APER (mouse) and CC1.3 (human). All are characterised by an N-terminal arginine-rich.ow complexity domain followed by three (or in the case of 4 human paralogs.wo) RNA recognition domains. These splicing factors are closely related to the U2AF splicing factor family ().
  IPR006509:Splicing factor, CC1-like
This entry represents nucleotide-binding domains with an alpha-beta plait structure.hich consists of either a ferredoxin-like (beta-alpha-beta)2 fold.uch as that found in RNA-binding domains of various ribonucleoproteins or in viral DNA-binding domains . or a beta-(alpha)-beta-alpha-beta(2) fold.uch as that found in the ribosomal protein L23 .
  IPR012677:Nucleotide-binding, alpha-beta plait
IPR000504:RRM_1 
Evalue:-31.0915145874023 
Location:252-323IPR000504:RRM 
Evalue:-14.6197887582884 
Location:154-226IPR000504:RRM 
Evalue:-1.0268721464003 
Location:425-504
SequencesProtein: RNPC2_HUMAN (530 aa)
mRNA: NM_184234
Local Annotation
Synapse Ontology
Calcium release from RyR (Ryanodine Receptor) in the SR (Sarcoplasmic Reticulum) is activated by the calcium induced-calcium-release
sdb:0325 RyR-CICR  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 325 residues, 33754944-33755917Exon2: 28 residues, 33756003-33756082Exon3: 37 residues, 33756560-33756666Exon4: 29 residues, 33758455-33758537Exon5: 19 residues, 33760559-33760610Exon6: 28 residues, 33764354-33764432Exon7: 70 residues, 33765520-33765725Exon8: 24 residues, 33768075-33768141Exon9: 48 residues, 33773075-33773213Exon10: 53 residues, 33775905-33776058Exon11: 41 residues, 33776373-33776491Exon12: 20 residues, 33780647-33780701Exon13: 24 residues, 33780797-33780863Exon14: 67 residues, 33783276-33783471Exon15: 18 residues, 33790303-33790353Exon16: 23 residues, 33792159-33792223Exon17: 112 residues, 33793276-33793607Exon18: 2 residues, -Jump to RNPC2_HUMAN  
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Loci Cluster (Details)Loci: 4520 33754944-33793607 ~-39K 23005(RNPC2)(-)Loci: 4519 33720024-33750688 ~-31K 22998(NFS1)(-)Link out to UCSC