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0RNF34_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameRNF34
DescriptionRing finger protein 34 (ring finger protein riff) (fyve-ring finger protein momo) (human ring finger homologous to inhibitor of apoptosis protein) (hrfi) (caspases-8 and -10-associated ring finger protein 1) (carp-1) (caspase regulator carp1).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GON/A
Domain Architecture (Details)
InterPro domains unassigned to SynO:
Quality control of intracellular proteins is essential for cellular homeostasis. Molecular chaperones recognise and contribute to the refolding of misfolded or unfolded proteins.hereas the ubiquitin-proteasome system mediates the degradation of such abnormal proteins. Ubiquitin-protein ligases (E3s) determine the substrate specificity for ubiquitylation and have been classified into HECT and RING-finger families. More recently.owever.-box proteins.hich contain a domain (the U box) of about 70 amino acids that is conserved from yeast to humans.ave been identified as a new type of E3 .The RING-finger is a specialised type of Zn-finger of 40 to 60 residues that binds two atoms of zinc.nd is probably involved in mediating protein-protein interactions. . There are two different variants.he C3HC4-type and a C3H2C3-type.hich is clearly related despite the different cysteine/histidine pattern. The latter type is sometimes referred to as RING-H2 finger. The RING domain is a protein interaction domain which has been implicated in a range of diverse biological processes.E3 ubiquitin-protein ligase activity is intrinsic to the RING domain ofc-Cbl and is likely to be a general function of this domain; Various RINGfingers exhibit binding to E2 ubiquitin-conjugating enzymes (Ubcs) .Several 3D-structures for RING-fingers are known . The 3D structure of the zinc ligation system is unique to the RING domain and is referred to as the cross-brace motif. The spacing of the cysteines in such a domain is C-x(2)-C-x(9 to 39)-C-x(1 to 3)-H-x(2 to 3)-C-x(2)-C-x(4 to 48)-C-x(2)-C. Metal ligand pairs one and three co-ordinate to bind one zinc ion.hilst pairs two and four bind the second.s illustrated in the following schematic representation:Note that in the older literature.ome RING-fingers are denoted as LIM-domains. The LIM-domain Zn-finger is a fundamentally different family.lbeit with similar Cys-spacing (see ).
  IPR001841:Zinc finger, RING-type
Zinc finger domains (ZnFs) are common.elatively small protein motifs that fold around one or more zinc ions. In addition to their role as a DNA-binding module.nFs have recently been shown to mediate protein:protein and protein:lipid interactions. There are at least 14 different classes of Zn fingers.hich differ in the nature and arrangement of their zinc-binding residues .The FYVE zinc finger domain is conserved from yeast to man.nd is named after four proteins that it has been found in: Fab1.OTB/ZK632.12.ac1.nd EEA1. It functions in the membrane recruitment of cytosolic proteins by binding to phosphatidylinositol 3-phosphate (PI3P).hich is found mainly on endosomes .The plant homeodomain (PHD) zinc finger domain has a C4HC3-type motif.nd is widely distributed in eukaryotes.eing found in many chromatin regulatory factors .Both the FYVE and the PHD zinc finger motifs display strikingly similar dimetal(zinc)-bound alpha+beta folds.The SSF signature in this entry is currently under review. Please be aware that some of the protein hits may be false positives.
  IPR011011:Zinc finger, FYVE/PHD-type
IPR001841:RING 
Evalue:-3.08092190762393 
Location:325-359IPR011011:FYVE_PHD_ZnF 
Evalue:0 
Location:51-108IPR000306:ZF_FYVE 
Evalue:0 
Location:0-0
SequencesProtein: RNF34_HUMAN (372 aa)
mRNA: NM_025126 NM_194271
Local Annotation
Synapse Ontology
mitochondria are frequently observed in the vicinity of the synaptic vesicle clusters, in agreement with the ATP requirement of several steps of the vesicle cycle.
sdb:0118 mitochondria  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 41 residues, 120322284-120322404Exon2: 75 residues, 120338344-120338563Exon3: 138 residues, 120339689-120340097Exon4: 33 residues, 120342427-120342520Exon5: 69 residues, 120342762-120342964Exon6: 324 residues, 120345571-120346538Exon7: 2 residues, -Jump to RNF34_HUMANExon1: 41 residues, 120322284-120322404Exon2: 24 residues, 120324927-120324993Exon3: 75 residues, 120338344-120338563Exon4: 138 residues, 120339689-120340097Exon5: 33 residues, 120342427-120342520Exon6: 69 residues, 120342762-120342964Exon7: 324 residues, 120345571-120346538Exon8: 2 residues, -Jump to RNF34_HUMAN  
Tune and view alternative isoforms
Loci Cluster (Details)Loci: 2796 120322284-120346538 ~-24K 9873(RNF34)(+)Loci: 4082 120159879-120220494 ~-61K 9864(CAMKK2)(-)Link out to UCSC