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0RNC_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameRNASE3L
DescriptionRibonuclease iii (ec 3.1.26.3) (rnase iii) (drosha) (p241).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005515 protein binding (IPI)
Domain Architecture (Details)
InterPro domains unassigned to SynO:
Prokaryotic ribonuclease III () (gene rnc) is an enzyme that digests double-stranded RNA. It is involved in the processing of ribosomal RNA precursors and of some mRNAs. RNase III is evolutionary related to the fission yeast pac1. ribonuclease that probablyinhibits mating and meiosis by degrading a specific mRNA required for sexual development; yeast ribonuclease III (gene RNT1). dsRNA-specific nuclease that cleaves eukaryotic preribosomal RNA at various sites; Caenorhabditis elegans hypothetical protein F26E4.13; Paramecium bursaria chlorella virus 1 protein A464R; Synechocystis strain PCC 6803 hypothetical protein slr0346; fission yeast hypothetical protein SpAC8A4.08c. protein with a N-terminal helicase domain and a C-terminal RNase III domain; andCaenorhabditis elegans hypothetical protein K12H4.8. protein with the same structure as SpAC8A4.08c.
  IPR000999:Ribonuclease III
The DsRBD domain is found in a variety of RNA-binding proteins with differentstructures and exhibiting a diversity of functions .It is involved in localization of at least five different mRNAs in the early Drosophila embryo and by interferon-induced protein kinase in humans.hich is part of the cellular response to dsRNA.
  IPR001159:Double-stranded RNA binding
IPR000999:RIBOc 
Evalue:-48.7958800173441 
Location:1122-1254IPR000999:RIBOc 
Evalue:-44.7695510786217 
Location:943-1077IPR001159:DSRM 
Evalue:-19.2365720064371 
Location:1261-1333IPR000999:RNase_III 
Evalue:0 
Location:866-910
SequencesProtein: RNC_HUMAN (1374 aa)
mRNA: NM_013235
Local Annotation
Synapse Ontology
Calcium release from RyR (Ryanodine Receptor) in the SR (Sarcoplasmic Reticulum) is activated by the calcium induced-calcium-release
sdb:0325 RyR-CICR  (Evidence:keywords)
KO assignmentK03685
  Level 3 annotation:
    ribonuclease III
  Level 2 annotation:
    Other translation proteins
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 168 residues, 31436925-31437426Exon2: 17 residues, 31441540-31441587Exon3: 33 residues, 31442716-31442809Exon4: 36 residues, 31444919-31445023Exon5: 29 residues, 31445113-31445196Exon6: 49 residues, 31446609-31446751Exon7: 37 residues, 31457135-31457241Exon8: 54 residues, 31458650-31458808Exon9: 17 residues, 31460290-31460335Exon10: 25 residues, 31465338-31465409Exon11: 36 residues, 31467439-31467542Exon12: 35 residues, 31471628-31471728Exon13: 22 residues, 31473102-31473162Exon14: 22 residues, 31484410-31484471Exon15: 48 residues, 31485144-31485283Exon16: 38 residues, 31487396-31487504Exon17: 38 residues, 31500099-31500207Exon18: 35 residues, 31502045-31502145Exon19: 43 residues, 31503802-31503927Exon20: 58 residues, 31507926-31508096Exon21: 27 residues, 31519417-31519492Exon22: 29 residues, 31520744-31520826Exon23: 26 residues, 31522354-31522426Exon24: 31 residues, 31529070-31529157Exon25: 31 residues, 31531149-31531236Exon26: 29 residues, 31540418-31540499Exon27: 53 residues, 31544484-31544639Exon28: 49 residues, 31546898-31547040Exon29: 79 residues, 31550851-31551083Exon30: 39 residues, 31551317-31551428Exon31: 33 residues, 31556986-31557079Exon32: 280 residues, 31561942-31562776Exon33: 24 residues, 31564903-31564969Exon34: 44 residues, 31566661-31566788Exon35: 26 residues, 31567853-31567925Exon36: 2 residues, -Jump to RNC_HUMAN  
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