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0RM46_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameMRPL46
Description39s ribosomal protein l46, mitochondrial precursor (l46mt) (mrp-l46) (p2ecsl).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GON/A
Domain Architecture (Details)
InterPro domains unassigned to SynO:
MutT is a small bacterial protein (~12-15Kd) involved in the GO system responsible for removing an oxidatively damaged form of guanine (8-hydroxy- guanine or 7.-dihydro-8-oxoguanine) from DNA and the nucleotide pool. 8-oxo-dGTP is inserted opposite dA and dC residues of template DNA with near equal efficiency.eading to A.T to G.C transversions. MutT specifically degrades 8-oxo-dGTP to the monophosphate.ith the concomitant release of pyrophosphate. A short conserved N-terminal region of mutT (designated the MutT domain) is also found in a variety of other prokaryotic.iral and eukaryotic proteins . The generic name NUDIX hydrolases (NUcleoside DIphosphate linked to some other moiety X) has been coined for this domain family . The family can be divided into a number of subgroups.f which MutT anti- mutagenic activity represents only one type; most of the rest hydrolyse diverse nucleoside diphosphate derivatives (including ADP-ribose.DP- mannose.DP-glucose.ADH.DP-sugars.NTP and NTP).
  IPR000086:NUDIX hydrolase
IPR000086:NUDIX_hydrolase 
Evalue:0 
Location:154-279
SequencesProtein: RM46_HUMAN (279 aa)
mRNA: AF205435 CR609481 NM_022163
Local Annotation
Synapse Ontology
mitochondria are frequently observed in the vicinity of the synaptic vesicle clusters, in agreement with the ATP requirement of several steps of the vesicle cycle.
sdb:0118 mitochondria  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 130 residues, 86803712-86804099Exon2: 59 residues, 86808938-86809111Exon3: 64 residues, 86809821-86810008Exon4: 78 residues, 86811384-86811614Exon5: 2 residues, -Jump to RM46_HUMANExon1: 130 residues, 86803712-86804099Exon2: 59 residues, 86808938-86809111Exon3: 64 residues, 86809821-86810008Exon4: 78 residues, 86811384-86811614Exon5: 2 residues, -Jump to RM46_HUMANExon1: 129 residues, 86803713-86804098Exon2: 60 residues, 86808937-86809111Exon3: 64 residues, 86809821-86810008Exon4: 81 residues, 86811384-86811623Exon5: 2 residues, -Jump to RM46_HUMANExon1: 119 residues, 86803743-86804098Exon2: 59 residues, 86808937-86809108Exon3: 64 residues, 86809821-86810008Exon4: 89 residues, 86811384-86811646Exon5: 2 residues, -Jump to RM46_HUMAN  
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