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0RM39_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameMRPL39
DescriptionMitochondrial 39s ribosomal protein l39 (l39mt) (mrp-l39) (mrp-l5).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005761 mitochondrial ribosome (NAS)
Domain Architecture (Details)
InterPro domains unassigned to SynO:
The TGS domain is present in a number of enzymes.or example.n threonyl-tRNA synthetase (ThrRS).TPase.nd guanosine-3.-bis(diphosphate) 3-pyrophosphohydrolase (SpoT) . The TGS domain is also present at the amino terminus of the uridine kinase from the spirochaete Treponema pallidum (but not any other organism.ncluding the related spirochaete Borrelia burgdorferi). TGS is a small domain that consists of ~50 amino acid residues and is predicted to possess a predominantly beta-sheet structure. There is no direct information on the functions of the TGS domain.ut its presence in two types of regulatory proteins (the GTPases and guanosine polyphosphate phosphohydrolases/synthetases) suggests a ligand (most likely nucleotide)-binding.egulatory role .
  IPR004095:TGS
The ferredoxin protein family are electron carrier proteins with an iron-sulphur cofactor that act in a wide variety of metabolic reactions. Ferredoxins can be divided into several subgroups depending upon the physiological nature of the iron-sulphur cluster(s) and according to sequence similarities. This entry represents members of the 2Fe-2S ferredoxin family that have a general core structure consisting of beta(2)-alpha-beta(2).hich includes putidaredoxin and terpredoxin.nd adrenodoxin . This entry also represents 2Fe-2S ferredoxin domains from multidomain proteins.uch as aldehyde oxidoreductase (N-terminal).anthine oxidase (N-terminal).hthalate dioxygenase reductase (C-terminal).uccinate dehydrogenase iron-sulphur protein (N-terminal).nd methane monooxygenase reductase (N-terminal). In addition.his entry includes the N-terminal additional domain of threonyl-tRNA synthetase (ThrRS). class II multi-domain enzyme that represses its own translation; the N-terminal additional domain has a beta(2)-alpha-beta(2) core structure .
  IPR012675:2Fe-2S Ferredoxin-like fold
The TGS domain is present in a number of enzymes.or example.n threonyl-tRNA synthetase (ThrRS).TPase.nd guanosine 3.-bis(diphosphate) 3-pyrophosphohydrolase (SpoT) . The TGS domain is also present at the amino terminus of the uridine kinase from the spirochaete Treponema pallidum (but not any other organism.ncluding the related spirochaete Borrelia burgdorferi). TGS is a small domain that consists of ~50 amino acid residues and is predicted to possess a predominantly beta-sheet structure. There is no direct information on the functions of the TGS domain.ut its presence in two types of regulatory proteins (the GTPases and guanosine polyphosphate phosphohydrolases/synthetases) suggests a ligand (most likely nucleotide)-binding.egulatory role . The TGS domain is possibly related to the ubiquitin-like and MoaD/ThiS superfamilies.nd has some similarity to the alpha-L RNA-binding motif.This entry represents TGS domain-containing proteins.s well as The C-terminal domain of bacterial and fungal YchF. universally conserved GTPase whose function is unknown .
  IPR012676:TGS-like
IPR004095:TGS 
Evalue:-1.88605666160583 
Location:67-129
SequencesProtein: RM39_HUMAN (338 aa)
mRNA: AF239727 AK000458 NM_017446 NM_080794
Local Annotation
Synapse Ontology
mitochondria are frequently observed in the vicinity of the synaptic vesicle clusters, in agreement with the ATP requirement of several steps of the vesicle cycle.
sdb:0118 mitochondria  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 33 residues, 25879840-25879937Exon2: 18 residues, 25883017-25883065Exon3: 53 residues, 25886994-25887148Exon4: 24 residues, 25888075-25888141Exon5: 39 residues, 25891484-25891597Exon6: 24 residues, 25893981-25894049Exon7: 35 residues, 25895550-25895650Exon8: 48 residues, 25897978-25898118Exon9: 71 residues, 25900631-25900838Exon10: 26 residues, 25901585-25901658Exon11: 2 residues, -Jump to RM39_HUMANExon1: 32 residues, 25879842-25879937Exon2: 18 residues, 25883017-25883065Exon3: 53 residues, 25886994-25887148Exon4: 24 residues, 25888075-25888141Exon5: 39 residues, 25891484-25891597Exon6: 24 residues, 25893981-25894049Exon7: 35 residues, 25895550-25895650Exon8: 48 residues, 25897978-25898118Exon9: 71 residues, 25900631-25900838Exon10: 28 residues, 25901585-25901664Exon11: 2 residues, -Jump to RM39_HUMANExon1: 32 residues, 25879842-25879937Exon2: 18 residues, 25883017-25883065Exon3: 53 residues, 25886994-25887148Exon4: 24 residues, 25888075-25888141Exon5: 39 residues, 25891484-25891597Exon6: 24 residues, 25893981-25894049Exon7: 35 residues, 25895550-25895650Exon8: 48 residues, 25897978-25898118Exon9: 71 residues, 25900631-25900838Exon10: 31 residues, 25901585-25901672Exon11: 2 residues, -Jump to RM39_HUMANExon1: 32 residues, 25879842-25879937Exon2: 31 residues, 25881883-25881972Exon3: 18 residues, 25883017-25883065Exon4: 53 residues, 25886994-25887148Exon5: 24 residues, 25888075-25888141Exon6: 39 residues, 25891484-25891597Exon7: 24 residues, 25893981-25894049Exon8: 35 residues, 25895550-25895650Exon9: 48 residues, 25897978-25898118Exon10: 71 residues, 25900631-25900838Exon11: 31 residues, 25901585-25901672Exon12: 2 residues, -Jump to RM39_HUMAN  
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