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0RM28_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
Description39s ribosomal protein l28, mitochondrial precursor (l28mt) (mrp-l28) (melanoma antigen p15) (melanoma-associated antigen recognized by t lymphocytes).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
Domain Architecture (Details)
InterPro domains unassigned to SynO:
This domain is found in a number of transcription factors.ncluding p53.FATC.onEBP.TAT-1.nd it is responsible for DNA-binding. These transcription factors play diverse roles in the regulation of cellular functions: the p53 tumour suppressor upregulates the expression of genes involved in cell cycle arrest and apoptosis ; NFATC regulates the production of effector proteins involved in coordinating the immune response ; TonEBP regulates gene expression induced by osmotic stress and helps regulate intracellular volume during cell growth ; STAT-1 plays an important role in B lymphocyte growth and function ; and NFkappaB is involved in the inflammatory response . The DNA-binding domain acts to clamp.r in the case of TonEBP.ncircle the DNA target in order to stabilize the protein-DNA complex . Protein interactions may also serve to stabilize the protein-DNA complex.or example in the STAT-1 dimer the SH2 (Src homology 2) domain in each monomer is coupled to the DNA-binding domain to increase stability . The DNA-binding domain consists of a beta-sandwich formed of 9 strands in 2 sheets with a Greek-key topology. This structure is found in many transcription factors.ften within the DNA-binding domain.The SSF signature in this entry is currently under review. Please be aware that some of the protein hits may be false positives.
  IPR008967:p53-like transcription factor, DNA-binding
SequencesProtein: RM28_HUMAN (287 aa)
mRNA: AK096844 NM_006428
Local Annotation
Synapse Ontology
mitochondria are frequently observed in the vicinity of the synaptic vesicle clusters, in agreement with the ATP requirement of several steps of the vesicle cycle.
sdb:0118 mitochondria  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 130 residues, 357394-357783Exon2: 31 residues, 358328-358415Exon3: 577 residues, 358501-360226Exon4: 11 residues, 360499-360527Exon5: 2 residues, -Jump to RM28_HUMANExon1: 130 residues, 357396-357783Exon2: 31 residues, 358328-358415Exon3: 47 residues, 358501-358636Exon4: 53 residues, 359068-359221Exon5: 100 residues, 359931-360226Exon6: 16 residues, 360499-360541Exon7: 2 residues, -Jump to RM28_HUMAN  
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Loci Cluster (Details)Loci: 2909 387192-390754 ~-4K 13162(NME4)(+)Loci: 2910 415668-512481 ~-97K 13166(RAB11FIP3)(+)Loci: 2911 580179-619272 ~-39K 13173(RAB40C)(+)Loci: 4199 774975-778384 ~-3K 13216(-)Loci: 2912 1143241-1211772 ~-69K 13223(CACNA1H)(+)Loci: 2913 1324663-1339443 ~-15K 13234(BAIAP3)(+)Loci: 4200 1435345-1465013 ~-30K 13244(CLCN7)(-)Loci: 2914 1696221-1760318 ~-64K 13253(MAPK8IP3)(+)Loci: 2915 1979968-1984276 ~-4K 13288(SYNGR3)(+)Loci: 2916 2016896-2028484 ~-12K 13290(SLC9A3R2)(+)Loci: 2917 2038599-2078713 ~-40K 13294(TSC2)(+)Loci: 2918 2138651-2144141 ~-5K 13300(RAB26)(+)Loci: 4201 2167184-2186466 ~-19K 13303(CASKIN1)(-)Loci: 4198 357394-360541 ~-3K 13159(MRPL28)(-)Link out to UCSC