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0RM27_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameMRPL27
DescriptionMitochondrial 39s ribosomal protein l27 (l27mt) (mrp-l27).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005762 mitochondrial large ribosomal subunit (NAS)
0003735 structural constituent of ribosome (NAS)
0006412 protein biosynthesis (NAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
Ribosomes are the particles that catalyze mRNA-directed protein synthesis in all organisms. The codons of the mRNA are exposed on the ribosome to allow tRNA binding. This leads to the incorporation of amino acids into the growing polypeptide chain in accordance with the genetic information. Incoming amino acid monomers enter the ribosomal A site in the form of aminoacyl-tRNAs complexed with elongation factor Tu (EF-Tu) and GTP. The growing polypeptide chain.ituated in the P site as peptidyl-tRNA.s then transferred to aminoacyl-tRNA and the new peptidyl-tRNA.xtended by one residue.s translocated to the P site with the aid the elongation factor G (EF-G) and GTP as the deacylated tRNA is released from the ribosome through one or more exit sites . About 2/3 of the mass of the ribosome consists of RNA and 1/3 of protein. The proteins are named in accordance with the subunit of the ribosome which they belong to - the small (S1 to S31) and the large (L1 to L44). Usually they decorate the rRNA cores of the subunits. Many of ribosomal proteins.articularly those of the large subunit.re composed of a globular.urfaced-exposed domain with long finger-like projections that extend into the rRNA core to stabilize its structure. Most of the proteins interact with multiple RNA elements.ften from different domains. In the large subunit.bout 1/3 of the 23S rRNA nucleotides are at least in van der Waals contact with protein.nd L22 interacts with all six domains of the 23S rRNA. Proteins S4 and S7.hich initiate assembly of the 16S rRNA.re located at junctions of five and four RNA helices.espectively. In this way proteins serve to organize and stabilize the rRNA tertiary structure. While the crucial activities of decoding and peptide transfer are RNA based.roteins play an active role in functions that may have evolved to streamline the process of protein synthesis. In addition to their function in the ribosome.any ribosomal proteins have some function outside the ribosome .L27 is a protein from the large (50S) subunit; it is essential for ribosome function.ut its exact role is unclear. It belongs to a family of ribosomal proteins.xamples of which are found in bacteria.hloroplasts of plants and red algae and the mitochondria of fungi (e.g. MRP7 from yeast mitochondria). The schematic relationship between these groups of proteins is shown below.
  IPR001684:Ribosomal protein L27
IPR001684:Ribosomal_L27 
Evalue:-17.7212467193604 
Location:31-115IPR001684:RIBOSOMAL_L27 
Evalue:0 
Location:0-0
SequencesProtein: RM27_HUMAN (148 aa)
mRNA: NM_016504
Local Annotation
Synapse Ontology
mitochondria are frequently observed in the vicinity of the synaptic vesicle clusters, in agreement with the ATP requirement of several steps of the vesicle cycle.
sdb:0118 mitochondria  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 144 residues, 45800227-45800658Exon2: 24 residues, 45802391-45802459Exon3: 46 residues, 45802814-45802946Exon4: 25 residues, 45805490-45805561Exon5: 2 residues, -Jump to RM27_HUMAN  
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Loci Cluster (Details)Loci: 4299 45545034-45562166 ~-17K 16176(-)Loci: 3018 45598389-45608288 ~-10K 16177(SGCA)(+)Loci: 4300 45800227-45805561 ~-5K 16185(MRPL27)(-)Loci: 3019 45965097-45975160 ~-10K 16195(EPN3)(+)Loci: 3020 45993447-46059430 ~-66K 16202(CACNA1G)(+)Loci: 3021 46067226-46124061 ~-57K 16218(ABCC3)(+)Loci: 3017 45527694-45543421 ~-16K 16175(PDK2)(+)Link out to UCSC