SynDB Home Page
SynDB Home Page

blue bulletSynDB protein details  

Parse error: syntax error, unexpected T_VARIABLE in /home/kongl/syndb/www/sdb_nats.php on line 52
0RIF1_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
DescriptionTelomere-associated protein rif1 (rap1-interacting factor 1 homolog).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
Domain Architecture (Details)
InterPro domains unassigned to SynO:
This domain consists of a multi-helical fold comprised of two curved layers of alpha helices arranged in a regular right-handed the repeats that make up this structure are arranged about a common axis . These superhelical structures present an extensive solvent-accessible surface that is well suited to binding large substrates such as proteins and nucleic acids. This topology has been found with a number of repeats and domains.ncluding the armadillo repeat (found in beta-catenins and importins).he HEAT repeat (found in protein phosphatase 2a and initiation factor eIF4G).he PHAT domain (found in Smaug RNA-binding protein).he leucine-rich repeat variant.he Pumilo repeat.nd in the H regulatory subunit of V-type ATPases. The sequence similarity among these different repeats or domains is low.owever they exhibit considerable structural similarity. Furthermore.he number of repeats present in the superhelical structure can vary between orthologues.ndicating that rapid loss/gain of repeats has occurred frequently in evolution. A common phylogenetic origin has been proposed for the armadillo and HEAT repeats .
  IPR011989:Armadillo-like helical
SequencesProtein: RIF1_HUMAN (2472 aa)
mRNA: NM_018151
Local Annotation
Synapse Ontology
microtubules of the presynaptic compartment function as the tracks for the intense traffic of organelles from cell body to axon terminals and vice versa. It is generally excluded from the presynaptic vesicle cluster.Microtubules do not directly regulate synapse morphology or function
sdb:0087 microtubules  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 41 residues, 151974673-151974793Exon2: 40 residues, 151975173-151975287Exon3: 28 residues, 151976019-151976098Exon4: 34 residues, 151979582-151979679Exon5: 44 residues, 151981320-151981448Exon6: 33 residues, 151981566-151981661Exon7: 65 residues, 151984949-151985139Exon8: 33 residues, 151987709-151987802Exon9: 48 residues, 151993543-151993682Exon10: 52 residues, 151997836-151997988Exon11: 41 residues, 152000222-152000340Exon12: 61 residues, 152001586-152001763Exon13: 39 residues, 152002000-152002111Exon14: 23 residues, 152003443-152003506Exon15: 35 residues, 152004786-152004887Exon16: 31 residues, 152006664-152006751Exon17: 25 residues, 152008018-152008089Exon18: 62 residues, 152008288-152008469Exon19: 38 residues, 152010097-152010205Exon20: 52 residues, 152011185-152011335Exon21: 35 residues, 152016365-152016465Exon22: 90 residues, 152019654-152019919Exon23: 16 residues, 152021337-152021380Exon24: 69 residues, 152022520-152022723Exon25: 35 residues, 152023570-152023670Exon26: 42 residues, 152024759-152024879Exon27: 52 residues, 152025897-152026049Exon28: 29 residues, 152027001-152027082Exon29: 20 residues, 152027171-152027226Exon30: 1081 residues, 152027643-152030880Exon31: 51 residues, 152032759-152032906Exon32: 28 residues, 152033233-152033311Exon33: 40 residues, 152033400-152033516Exon34: 53 residues, 152034470-152034624Exon35: 38 residues, 152038723-152038832Exon36: 351 residues, 152039616-152040664Exon37: 2 residues, -Jump to RIF1_HUMAN  
Tune and view alternative isoforms