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0RHOB_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameRHOB
DescriptionRho-related gtp-binding protein rhob (h6).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0010008 endosome membrane (IDA)
0005634 nucleus (ISS)
0005886 plasma membrane (IDA)
0005525 GTP binding (TAS)
0007155 cell adhesion (ISS)
0008333 endosome to lysosome transport (IDA)
0045786 negative regulation of progression through ... (ISS)
0045766 positive regulation of angiogenesis (ISS)
0006927 programmed cell death, transformed cells (ISS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
Small GTPases are involved in intracellular cell signalling processes. The Ras family includes a large number of small GTPases. Members of the Rho subfamily of Ras-like small GTPases include Cdc42 and Rac.s well as Rho isoforms.The crystal structure of a number of the members of this entry have been determined: Rnd3/RhoE .hoA and Cdc42 .
  IPR003578:Ras small GTPase, Rho type
Many members of the Ras superfamily of GTPases have been implicated in the regulation of hematopoietic cells.ith roles in growth.urvival.ifferentiation.ytokine production.hemotaxis.esicle-trafficking.nd phagocytosis. The Ras superfamily of proteins now includes over 150 small GTPases (distinguished from the large.eterotrimeric GTPases.he G-proteins). It comprises six subfamilies.he Ras.ho.an.ab.rf.nd Kir/Rem/Rad subfamilies . They exhibit remarkable overall amino acid identities.specially in the regions interacting with the guanine nucleotide exchange factors that catalyze their activation .
  IPR013753:Ras
Many members of the Ras superfamily of GTPases have been implicated in the regulation of hematopoietic cells.ith roles in growth.urvival.ifferentiation.ytokine production.hemotaxis.esicle-trafficking.nd phagocytosis. The Ras superfamily of proteins now includes over 150 small GTPases (distinguished from the large.eterotrimeric GTPases.he G-proteins). It comprises six subfamilies.he Ras.ho.an.ab.rf.nd Kir/Rem/Rad subfamilies . They exhibit remarkable overall amino acid identities.specially in the regions interacting with the guanine nucleotide exchange factors that catalyze their activation .
  IPR001806:Ras GTPase
Proteins with a small GTP-binding domain include Ras.hoA.ab11.ranslation elongation factor G.ranslation initiation factor IF-2.etratcycline resistance protein TetM.DC42.ra.DP-ribosylation factors.dhF.nd many others . In some proteins the domain occurs more than once. Among them there is a large number of small GTP-binding proteins and related domains in larger proteins. Note that the alpha chains of heterotrimeric G proteins are larger proteins in which the NKXD motif is separated from the GxxxxGK[ST] motif (P-loop) by a long insert and are not easily detected by this model.
  IPR005225:Small GTP-binding protein domain
IPR003578:RHO 
Evalue:-126.958607314842 
Location:8-181
SequencesProtein: RHOB_HUMAN (196 aa)
mRNA: NM_004040
Local Annotation
Synapse Ontology
endosome of the presynaptic compartment. A cellular structure that is involved in the transport of proteins in the neuron after the proteins are endocytosed from the outside to the inside of the cell.
sdb:0088 endosome  (Evidence:keywords)
KO assignmentK07856
  Level 3 annotation:
    Ras homolog gene family, member B
  Level 2 annotation:
    GTP-binding proteins
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 789 residues, 20510315-20512681Exon2: 2 residues, -Jump to RHOB_HUMAN  
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