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0RFIP5_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameRAB11FIP5
DescriptionRab11 family-interacting protein 5 (rab11-fip5) (rab11-interacting protein rip11) (gamma-snap-associated factor 1) (gaf-1) (phosphoprotein pp75).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005741 mitochondrial outer membrane (IDA)
0043015 gamma-tubulin binding (IDA)
0005515 protein binding (IPI)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
The C2 domain is a Ca2+-dependent membrane-targeting module found in many cellular proteins involved in signal transduction or membrane trafficking. C2 domains are unique among membrane targeting domains in that they show wide range of lipid selectivity for the major components of cell membranes.ncluding phosphatidylserine and phosphatidylcholine. This C2 domain is about 116 amino-acid residues and is located between the two copies ofthe C1 domain in Protein Kinase C (that bind phorbol esters and diacylglycerol) (see )and the protein kinase catalytic domain (see ). Regions withsignificant homology to the C2-domain have been found in many proteins.The C2 domain is thought to be involved in calcium-dependent phospholipidbinding and in membrane targetting processes such as subcellular localisation. The 3D structure of theC2 domain of synaptotagmin has been reported.he domain forms an eight-stranded beta sandwich constructed around a conserved 4-stranded motif.esignated a C2 key . Calcium binds ina cup-shaped depression formed by the N- and C-terminal loops of theC2-key motif. Structural analyses of several C2 domains have shown them to consist of similar ternary structures in which three Ca2+-binding loops are located at the end of an 8 stranded antiparallel beta sandwich.
  IPR000008:C2 calcium-dependent membrane targeting
The Ca2+-dependent.ipid-binding domain (CaLB) has been identified in a number of proteins.or example the amino-terminal.38 amino acid C2 domain of cytosolic phospholipase A2 (cPLA2-C2) which mediates an initial step in the production of lipid mediators of inflammation: the Ca2+-dependent translocation of the enzyme to intracellular membranes with subsequent liberation of arachidonic acid. The domain is composed of eight antiparallel beta-strands with six interconnecting loops that fits the "type II" topology for C2 domains. The structure has been identified as a beta-sandwich in the "Greek key" motif .The SSF signature in this entry is currently under review. Please be aware that some of the protein hits may be false positives.
  IPR008973:C2 calcium/lipid-binding region, CaLB
IPR000008:C2 
Evalue:-13.8538722991943 
Location:21-85
SequencesProtein: RFIP5_HUMAN (653 aa)
mRNA: NM_015470
Local Annotation
Synapse Ontology
endosome of the presynaptic compartment. A cellular structure that is involved in the transport of proteins in the neuron after the proteins are endocytosed from the outside to the inside of the cell.
sdb:0088 endosome  (Evidence:keywords)
mitochondria are frequently observed in the vicinity of the synaptic vesicle clusters, in agreement with the ATP requirement of several steps of the vesicle cycle.
sdb:0118 mitochondria  (Evidence:keywords)
?
sdb:0329 actin in synaptic vesicle cycling  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 781 residues, 73154018-73156360Exon2: 65 residues, 73156628-73156818Exon3: 235 residues, 73168685-73169385Exon4: 147 residues, 73169514-73169951Exon5: 225 residues, 73192982-73193653Exon6: 2 residues, -Jump to RFIP5_HUMAN  
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Loci Cluster (Details)Loci: 4447 73154018-73193653 ~-40K 20643(RAB11FIP5)(-)Loci: 4448 73371573-73374118 ~-3K 20647(EGR4)(-)Loci: 4446 73022673-73152473 ~-130K 20642(SFXN5)(-)Link out to UCSC