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0RFIP4_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameRAB11FIP4
DescriptionRab11-family interacting protein 4 (rab11-fip4).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GON/A
Domain Architecture (Details)
InterPro domains unassigned to SynO:
Many calcium-binding proteins belong to the same evolutionary family and share a type of calcium-binding domain known as the EF-hand. This type of domain consists of a twelve residue loop flanked on both side by a twelve residue alpha-helical domain. In an EF-hand loop the calcium ion is coordinated in a pentagonal bipyramidal configuration. The six residues involved in the binding are in positions 1.... and 12; these residues are denoted by X...Y.X and -Z. The invariant Glu or Asp at position 12 provides two oxygens for liganding Ca (bidentate ligand).
  IPR002048:Calcium-binding EF-hand
This domain consists of a duplication of two EF-hand units.here each unit is composed of two helices connected by a twelve-residue calcium-binding loop. The calcium ion in the EF-hand loop is coordinated in a pentagonal bipyramidal configuration. Many calcium-binding proteins contain an EF-hand type calcium-binding domain . These include: calbindin D9K.100 proteins such as calcyclin.olcalcin phl p 7 (a calcium-binding pollen allergen).steonectin.arvalbumin.almodulin family of proteins (troponin C.altractin.dc4p.yosin essential chain.alcineurin.ecoverin.eurocalcin).lasmodial-specific CaII-binding protein Cbp40.enta-EF-Hand proteins (sorcin.rancalcin.alpain).s well as multidomain proteins such as phosphoinositide-specific phospholipase C.ystrophin.b1 and alpha-actinin. The fold consists of four helices and an open array of two hairpins.
  IPR011992:EF-Hand type
IPR011992:EF-Hand_type 
Evalue:0 
Location:17-101IPR002048:EF_HAND_1 
Evalue:0 
Location:0-0
SequencesProtein: RFIP4_HUMAN (637 aa)
mRNA: AY169244 NM_032932
Local Annotation
Synapse Ontology
endosome of the presynaptic compartment. A cellular structure that is involved in the transport of proteins in the neuron after the proteins are endocytosed from the outside to the inside of the cell.
sdb:0088 endosome  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 130 residues, 26742767-26743155Exon2: 31 residues, 26782956-26783044Exon3: 31 residues, 26785177-26785266Exon4: 77 residues, 26868788-26869015Exon5: 67 residues, 26872303-26872498Exon6: 47 residues, 26873052-26873187Exon7: 14 residues, 26873497-26873533Exon8: 35 residues, 26874649-26874749Exon9: 36 residues, 26875030-26875134Exon10: 49 residues, 26876227-26876368Exon11: 29 residues, 26878979-26879061Exon12: 48 residues, 26879543-26879681Exon13: 55 residues, 26879757-26879916Exon14: 50 residues, 26881463-26881607Exon15: 2201 residues, 26882753-26889352Exon16: 2 residues, -Jump to RFIP4_HUMANExon1: 131 residues, 26742767-26743158Exon2: 30 residues, 26782959-26783044Exon3: 31 residues, 26785177-26785266Exon4: 77 residues, 26868788-26869015Exon5: 67 residues, 26872303-26872498Exon6: 47 residues, 26873052-26873187Exon7: 14 residues, 26873497-26873533Exon8: 35 residues, 26874649-26874749Exon9: 36 residues, 26875030-26875134Exon10: 49 residues, 26876227-26876368Exon11: 29 residues, 26878979-26879061Exon12: 48 residues, 26879543-26879681Exon13: 55 residues, 26879757-26879916Exon14: 50 residues, 26881463-26881607Exon15: 1218 residues, 26882753-26886401Exon16: 2 residues, -Jump to RFIP4_HUMAN  
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Loci Cluster (Details)Loci: 2994 25828551-25877957 ~-49K 15450(GOSR1)(+)Loci: 2995 26273058-26310335 ~-37K 15466(CENTA2)(+)Loci: 2996 26446242-26725609 ~-279K 15473(NF1)(+)Loci: 2997 26742767-26889352 ~-147K 15482(RAB11FIP4)(+)Loci: 4279 25549033-25586831 ~-38K 15444(SLC6A4)(-)Link out to UCSC