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0RF1M_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameMTRF1
DescriptionPeptide chain release factor 1, mitochondrial precursor (mrf-1).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005739 mitochondrion (TAS)
0003747 translation release factor activity (TAS)
0006449 regulation of translational termination (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
Peptide chain release factors (RFs) are required for the termination ofprotein biosynthesis . At present two classes of RFs can be distinguished.Class I RFs bind to ribosomes that have encountered a stop codon at theirdecoding site and induce release of the nascent polypeptide. Class II RFs areGTP-binding proteins that interact with class I RFs and enhance class I RFactivity.In prokaryotes there are two class I RFs that act in a codon specific manner: RF-1 (gene prfA) mediates UAA and UAG-dependent termination while RF-2(gene prfB) mediates UAA and UGA-dependent termination. RF-1 and RF-2 arestructurally and evolutionary related proteins which have been shown tobe part of a larger family.
  IPR000352:Class I peptide chain release factor
This domain is found in peptide chain release factors.
  IPR005139:PCRF
This group represents a protein chain release factor.F-1/RF-2. Please see the following relevant references: .
  IPR012086:Protein chain release factor, RF-1/RF-2
IPR000352:RF-1 
Evalue:-71.8239059448242 
Location:286-399IPR005139:PCRF 
Evalue:-47.0506095886231 
Location:138-254
SequencesProtein: RF1M_HUMAN (445 aa)
mRNA: NM_004294
Local Annotation
Synapse Ontology
mitochondria are frequently observed in the vicinity of the synaptic vesicle clusters, in agreement with the ATP requirement of several steps of the vesicle cycle.
sdb:0118 mitochondria  (Evidence:keywords)
KO assignmentK02835
  Level 3 annotation:
    peptide chain release factor RF-1
  Level 2 annotation:
    Translation factors
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 283 residues, 40688516-40689364Exon2: 35 residues, 40695391-40695490Exon3: 47 residues, 40698567-40698704Exon4: 41 residues, 40706025-40706143Exon5: 59 residues, 40712396-40712569Exon6: 38 residues, 40724780-40724888Exon7: 29 residues, 40725084-40725166Exon8: 32 residues, 40726664-40726756Exon9: 143 residues, 40732628-40733051Exon10: 33 residues, 40735620-40735713Exon11: 2 residues, -Jump to RF1M_HUMAN  
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Loci Cluster (Details)Loci: 4095 40688516-40735713 ~-47K 10296(MTRF1)(-)Loci: 2811 40261632-40281965 ~-20K 10287(SLC25A15)(+)Link out to UCSC