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0RDH11_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameRDH11
DescriptionRetinol dehydrogenase 11 (ec 1.1.1.-) (retinal reductase 1) (ralr1) (prostate short-chain dehydrogenase/reductase 1) (androgen-regulated short-chain dehydrogenase/reductase 1) (hcv core-binding protein hcbp12).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005622 intracellular (ISS)
0004745 retinol dehydrogenase activity (ISS)
0045494 photoreceptor maintenance (ISS)
0042572 retinol metabolism (ISS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
The short-chain dehydrogenases/reductases family (SDR) is a very large family of enzymes.ost of which are known to be NAD- or NADP-dependent oxidoreductases. As the first member of this family to be characterized was Drosophila alcohol dehydrogenase.his family used to be called insect-type.r short-chain alcohol dehydrogenases. Most member of this family are proteins of about 250 to 300 amino acid residues. Most dehydrogenases possess at least 2 domains .he first binding the coenzyme.ften NAD.nd the second binding the substrate. This latter domain determines the substrate specificity and contains amino acids involved in catalysis. Little sequence similarity has been found in the coenzyme binding domain although there is a large degree of structural similarity.nd it has therefore been suggested that the structure of dehydrogenases has arisen through gene fusion of a common ancestral coenzyme nucleotide sequence with various substrate specific domains .
  IPR002198:Short-chain dehydrogenase/reductase SDR
Glucose dehydrogenase catalyses the oxidation of D-glucose without priorphosphorylation to D-beta-gluconolactone using NAD or NADP as a coenzyme.The enzyme is a tetrameric protein.ach of the 4 identical subunitscontaining 262 amino acid residues. This family is a subset of a more general family of short-chain dehydrogenases andreductases.A match to this extension indicates that the protein is notan alcohol dehydrogenase.ut another type of dehydrogenaseor reductase.
  IPR002347:Glucose/ribitol dehydrogenase
IPR002198:adh_short 
Evalue:-16.4948501586914 
Location:42-189IPR002198:SDRFAMILY 
Evalue:0 
Location:202-221IPR002347:GDHRDH 
Evalue:0 
Location:223-240IPR002198:ADH_SHORT 
Evalue:0 
Location:0-0
SequencesProtein: RDH11_HUMAN (318 aa)
mRNA: NM_016026
Local Annotation
Synapse Ontology
the mechanism by which the restiong potential is held.
sdb:0288 maintain membrane potential  (Evidence:keywords)
KO assignmentK00100
  Level 3 annotation:
    
  Level 2 annotation:
    Fructose and mannose metabolism
    Galactose metabolism
    Ascorbate and aldarate metabolism
    Nucleotide sugars metabolism
    Butanoate metabolism
    Bile acid biosynthesis
    Glycerophospholipid metabolism
    Linoleic acid metabolism
    Glycine
     serine and threonine metabolism
    Lysine degradation
    Tetrachloroethene degradation
    Bisphenol A degradation
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 542 residues, 67213270-67214893Exon2: 65 residues, 67221484-67221674Exon3: 72 residues, 67226681-67226891Exon4: 37 residues, 67227609-67227714Exon5: 54 residues, 67228907-67229063Exon6: 41 residues, 67229403-67229522Exon7: 40 residues, 67232099-67232213Exon8: 2 residues, -Jump to RDH11_HUMAN  
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Loci Cluster (Details)Loci: 2850 67156331-67188187 ~-32K 11338(ARG2)(+)Loci: 4135 67187618-67211301 ~-24K 11340(VTI1B)(-)Loci: 4136 67213270-67232213 ~-19K 11341(RDH11)(-)Loci: 2849 66777773-66872288 ~-95K 11329(MPP5)(+)Link out to UCSC