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0RCC2_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameRCC2
DescriptionRcc2 protein (telophase disk protein of 60 kda) (rcc1-like protein td- 60).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GON/A
Domain Architecture (Details)
InterPro domains unassigned to SynO:
The regulator of chromosome condensation (RCC1) is a eukaryotic proteinwhich binds to chromatin and interacts with ran. nuclear GTP-bindingprotein .o promote the loss of bound GDP and the uptake offresh GTP.hus acting as a guanine-nucleotide dissociation stimulator (GDS).The interaction of RCC1 with ran probably plays an important role in theregulation of gene expression.RCC1.nown as PRP20 or SRM1 in yeast.im1 in fission yeast and BJ1 inDrosophila.s a protein that contains seven tandem repeats of a domain ofabout 50 to 60 amino acids. As shown in the following schematicrepresentation.he repeats make up the major part of the length of theprotein. Outside the repeat region.here is just a small N-terminal domain ofabout 40 to 50 residues and.n the Drosophila protein only. C-terminaldomain of about 130 residues.The RCC1-type of repeat is also found in the X-linked retinitis pigmentosaGTPase regulator . The RCC repeats form a beta-propellerstructure.
  IPR000408:Regulator of chromosome condensation, RCC1
The beta-lactamase-inhibitor protein II (BLIP-II) is a secreted protein produced by the soil bacteria Streptomyces exfoliates SMF19. BLIP-II acts as a potent inhibitor of beta-lactamases such as TEM-1.hich is the most widespread resistance enzyme to penicillin antibiotics. BLIP-II binds competitively to TEM-1.ut no direct contacts are made with TEM-1 active site residues. BLIP-II shows no sequence similarity with BLIP.ven though both bind to and inhibit TEM-1. However.LIP-II does share significant sequence identity with the regulator of chromosome condensation (RCC1) family of proteins. These two families are clearly related.oth having a seven-bladed beta-propeller structure.lthough they differ in the number of strands per blade.LIP-II having three antiparallel beta-strands per blade.hile RCC1 has four-stranded blades . RCC1 is a eukaryotic nuclear protein that acts as a guanine nucleotide exchange factor for Ran. member of the Ras GTPase family. RCC1 mediates a Ran-GTP gradient necessary for the regulation of spindle formation and nuclear assembly during mitosis.s well as for the transport of macromolecules across the nuclear membrane during interphase.The SSF signature in this entry is currently under review. Please be aware that some of the protein hits may be false positives.
  IPR009091:Regulator of chromosome condensation/beta-lactamase-inhibitor protein II
IPR009091:RCC1/BLIP-II 
Evalue:0 
Location:90-506IPR000408:RCC1_1 
Evalue:0 
Location:0-0
SequencesProtein: RCC2_HUMAN (522 aa)
mRNA: NM_018715
Local Annotation
Synapse Ontology
microtubules of the presynaptic compartment function as the tracks for the intense traffic of organelles from cell body to axon terminals and vice versa. It is generally excluded from the presynaptic vesicle cluster.Microtubules do not directly regulate synapse morphology or function
sdb:0087 microtubules  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 805 residues, 17605865-17608277Exon2: 28 residues, 17609056-17609134Exon3: 26 residues, 17611204-17611277Exon4: 37 residues, 17612155-17612261Exon5: 62 residues, 17612619-17612800Exon6: 57 residues, 17615562-17615729Exon7: 40 residues, 17619796-17619911Exon8: 31 residues, 17621285-17621374Exon9: 46 residues, 17621787-17621919Exon10: 50 residues, 17624623-17624767Exon11: 33 residues, 17628188-17628282Exon12: 99 residues, 17637312-17637605Exon13: 62 residues, 17638627-17638807Exon14: 2 residues, -Jump to RCC2_HUMAN  
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Loci Cluster (Details)Loci: 3774 17605865-17638807 ~-33K 519(RCC2)(-)Loci: 3773 17217840-17253233 ~-35K 510(SDHB)(-)Link out to UCSC