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0RBNS5_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameZFYVE20
DescriptionRabenosyn-5 (fyve finger-containing rab5 effector protein rabenosyn-5) (zinc finger fyve domain-containing protein 20) (110 kda protein).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005768 endosome (NAS)
0008270 zinc ion binding (NAS)
0016197 endosome transport (NAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
The FYVE zinc finger is named after four proteins that it has been found in: Fab1.OTB/ZK632.12.ac1.nd EEA1. The FYVE finger has been shown to bind two Zn2+ ions . The FYVE finger has eight potential zinc coordinating cysteine positions. Many members of this family also include two histidines in a motif R+HHC+XCG.here + represents a charged residue and X any residue.
  IPR000306:Zinc finger, FYVE-type
Zinc finger domains .re nucleic acid-binding protein structures first identified in the Xenopus laevis transcription factor TFIIIA. These domains have since been found in numerous nucleic acid-binding proteins. A zinc finger domain is composed of 25 to 30 amino-acid residues including 2 conserved Cys and 2 conserved His residues in a C-2-C-12-H-3-H type motif. The 12 residues separating the second Cys and the first His are mainly polar and basic.mplicating this region in particular in nucleic acid binding. The zinc finger motif is an unusually small.elf-folding domain in which Zn is a crucial component of its tertiary structure. All bind 1 atom of Zn in a tetrahedral array to yield a finger-like projection.hich interacts with nucleotides in the major groove of the nucleic acid. The Zn binds to the conserved Cys and His residues. Fingers have been found to bind to about 5 base pairs of nucleic acid containing short runs of guanine residues. They have the ability to bind to both RNA and DNA.nd it has been suggested that the zinc finger may thus represent the original nucleic acid binding protein. It has also been suggested that a Zn-centred domain could be used in a protein interaction..g. in protein kinase C. Many classes of zinc fingers are characterized according to the number and positions of the histidine and cysteine residues involved in the zinc atom coordination. In the first class to be characterized.alled C2H2.he first pair of zinc coordinating residues are cysteines.hile the second pair are histidines.
  IPR007087:Zinc finger, C2H2-type
IPR000306:FYVE 
Evalue:-11.6197891235352 
Location:152-261IPR007087:ZINC_FINGER_C2H2_2 
Evalue:0 
Location:14-42IPR003903:UIM 
Evalue:0 
Location:0-0
SequencesProtein: RBNS5_HUMAN (784 aa)
mRNA: NM_022340
Local Annotation
Synapse Ontology
endosome of the presynaptic compartment. A cellular structure that is involved in the transport of proteins in the neuron after the proteins are endocytosed from the outside to the inside of the cell.
sdb:0088 endosome  (Evidence:keywords)
?
sdb:0329 actin in synaptic vesicle cycling  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 1620 residues, 15086583-15091441Exon2: 37 residues, 15092116-15092221Exon3: 36 residues, 15093572-15093675Exon4: 31 residues, 15094585-15094672Exon5: 25 residues, 15097242-15097313Exon6: 82 residues, 15098877-15099119Exon7: 56 residues, 15101245-15101407Exon8: 17 residues, 15101510-15101556Exon9: 35 residues, 15102371-15102472Exon10: 49 residues, 15106909-15107050Exon11: 107 residues, 15112483-15112799Exon12: 60 residues, 15113045-15113221Exon13: 54 residues, 15114629-15114785Exon14: 40 residues, 15115545-15115659Exon15: 2 residues, -Jump to RBNS5_HUMAN  
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Loci Cluster (Details)Loci: 4589 15271249-15349108 ~-78K 25260(SH3BP5)(-)Loci: 3336 15443865-15459123 ~-15K 25264(EAF1)(+)Loci: 4590 15466644-15538262 ~-72K 25267(COLQ)(-)Loci: 4588 15086583-15115659 ~-29K 25257(ZFYVE20)(-)Link out to UCSC