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0RBM4_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameRBM4
DescriptionRna-binding protein 4 (rna-binding motif protein 4) (lark homolog) (hlark) (rna-binding motif protein 4a).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GON/A
Domain Architecture (Details)
InterPro domains unassigned to SynO:
Many eukaryotic proteins that are known or supposed to bind single-stranded RNA contain one or more copies of a putative RNA-binding domain of about 90 amino acids. This is known as the eukaryotic putative RNA-binding region RNP-1 signature or RNA recognition motif (RRM). RRMs are found in a variety of RNA binding proteins.ncluding heterogeneous nuclear ribonucleoproteins (hnRNPs).roteins implicated in regulation of alternative splicing.nd protein components of small nuclear ribonucleoproteins (snRNPs). The RRM in heterodimeric splicing factor U2 snRNP auxiliary factor (U2AF) appears to have two RRM-like domains with specialized features for protein recognition . The motif also appears in a few single stranded DNA binding proteins. The RRM structure consists of four strands and two helices arranged in an alpha/beta sandwich.ith a third helix present during RNA binding in some cases .
  IPR000504:RNA-binding region RNP-1 (RNA recognition motif)
The 18 residues CCHC zinc finger domain is mainly found in the Nucleocapsid protein of retrovirus. It is required for viral genome packaging and for early infection process . It is also found in eukaryotic proteins involved in RNA binding or single strand DNA binding.
  IPR001878:Zinc finger, CCHC-type
Allergies are hypersensitivity reactions of the immune system to specific substances called allergens (such as pollen.tings.rugs.r food) that.n most people.esult in no symptoms. A nomenclature system has been established for antigens (allergens) that cause IgE-mediated atopic allergies in humans [WHO/IUIS Allergen Nomenclature Subcommittee King T.P..offmann D..oewenstein H..arsh D.G..latts-Mills T.A.E..homas W. Bull. World Health Organ. 72:797-806(1994)]. This nomenclature system is defined by a designation that is composed ofthe first three letters of the genus; a space; the first letter of thespecies name; a space and an arabic number. In the event that two speciesnames have identical designations.hey are discriminated from one anotherby adding one or more letters (as necessary) to each species designation. The allergens in this family include allergens with the following designations: Lol p 5 and Poa p 9.Grass pollen allergens are one of the major causes of type I allergies (including allergic rhinoconjunctivitis.llergic bronchial asthma and hayfever).fflicting 15-20% of a genetically predisposed population . The amino acid sequences of three Kentucky bluegrass (KBG.oa pratensis) pollen allergen cDNA clones (KBG 41.0 and 31).ave been determined . The clones exhibit a high degree of sequence similarity to one another.inor similarity to other known allergens.nd no similarity to other known proteins or genes. The predicted molecular masses of the proteins range from 28.3 to 37.8 kDa . Northern analysis indicates that expression of the genes is confined to pollen tissue. The results suggest that the clones code for a group of proteins that represent a new and previously uncharacterised group of grass pollen isoallergens.hich have been designated Poa p 9 .The C-terminal fragment.onserved in Poa p 9 proteins.ppears to contain epitopes unique to these proteins . The N-terminal region () of Poa p 9 has been shown to possess epitopes that cross-react with the acidic group V allergens of Timothy grass . Comparison of amino acid sequences of recombinant Poa p 9 proteins with those of Lol p 5 isoallergens revealed a low level of similarity between the N-terminal sequences of these proteins .
  IPR001778:Pollen allergen Poa pIX/Phl pVI, C-terminal
This entry represents nucleotide-binding domains with an alpha-beta plait structure.hich consists of either a ferredoxin-like (beta-alpha-beta)2 fold.uch as that found in RNA-binding domains of various ribonucleoproteins or in viral DNA-binding domains . or a beta-(alpha)-beta-alpha-beta(2) fold.uch as that found in the ribosomal protein L23 .
  IPR012677:Nucleotide-binding, alpha-beta plait
IPR000504:RRM 
Evalue:-20.0809219076239 
Location:79-144IPR000504:RRM 
Evalue:-19.2757241303992 
Location:3-68IPR001878:zf-CCHC 
Evalue:-6.63827228546143 
Location:160-177IPR001778:POAALLERGEN 
Evalue:0 
Location:229-248IPR001778:POAALLERGEN 
Evalue:0 
Location:284-298
SequencesProtein: RBM4_HUMAN (364 aa)
mRNA: BC032735
Local Annotation
Synapse Ontology
Calcium release from RyR (Ryanodine Receptor) in the SR (Sarcoplasmic Reticulum) is activated by the calcium induced-calcium-release
sdb:0325 RyR-CICR  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 16 residues, 66162753-66162799Exon2: 143 residues, 66163746-66164170Exon3: 232 residues, 66167496-66168187Exon4: 149 residues, 66170073-66170514Exon5: 2 residues, -Jump to RBM4_HUMAN  
Tune and view alternative isoforms
Loci Cluster (Details)Loci: 2672 63498654-63500590 ~-2K 6992(COX8A)(+)Loci: 2673 63758841-63762834 ~-4K 7008(VEGFB)(+)Loci: 2674 63775570-63791969 ~-16K 7011(PLCB3)(+)Loci: 2675 63883200-63896262 ~-13K 7031(RPS6KA4)(+)Loci: 3958 64130223-64247236 ~-117K 7042(NRXN2)(-)Loci: 3959 64376783-64402767 ~-26K 7059(EHD1)(-)Loci: 2676 64551485-64564618 ~-13K 7071(SNX15)(+)Loci: 2677 64635935-64640274 ~-4K 7081(TM7SF2)(+)Loci: 2678 64705918-64736052 ~-30K 7088(CAPN1)(+)Loci: 2679 65049159-65062750 ~-14K 7102(+)Loci: 3960 65121802-65138296 ~-16K 7115(MAP3K11)(-)Loci: 3961 65407787-65412586 ~-5K 7136(FIBP)(-)Loci: 3962 65416267-65424573 ~-8K 7139(FOSL1)(-)Loci: 2680 65594399-65768789 ~-174K 7153(PACS1)(+)Loci: 2681 65792680-65801537 ~-9K 7155(RAB1B)(+)Loci: 2682 65815916-65820707 ~-5K 7159(+)Loci: 3963 65856117-65860576 ~-4K 7162(RIN1)(-)Loci: 2683 66140672-66151387 ~-11K 7189(RBM14)(+)Loci: 2684 66162753-66170514 ~-8K 7192(RBM4)(+)Loci: 3964 66209298-66245446 ~-36K 7194(SPTBN2)(-)Loci: 3965 66372572-66478456 ~-106K 7198(PC)(-)Loci: 2685 66547466-66574905 ~-27K 7200(SYT12)(+)Loci: 2686 66580896-66596059 ~-15K 7201(RHOD)(+)Loci: 3966 66922227-66925952 ~-4K 7219(PPP1CA)(-)Loci: 2687 66979393-66983261 ~-4K 7229(CABP4)(+)Loci: 2688 67130982-67136581 ~-6K 7239(NDUFV1)(+)Loci: 2689 67554684-67560690 ~-6K 7248(NDUFS8)(+)Loci: 2690 67836710-67973317 ~-137K 7259(LRP5)(+)Loci: 2671 63412650-63433621 ~-21K 6988(MARK2)(+)Link out to UCSC