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0RBM23_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameRBM23
DescriptionProbable rna-binding protein 23 (rna-binding motif protein 23) (rna- binding region containing protein 4) (splicing factor sf2).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GON/A
Domain Architecture (Details)
InterPro domains unassigned to SynO:
Many eukaryotic proteins that are known or supposed to bind single-stranded RNA contain one or more copies of a putative RNA-binding domain of about 90 amino acids. This is known as the eukaryotic putative RNA-binding region RNP-1 signature or RNA recognition motif (RRM). RRMs are found in a variety of RNA binding proteins.ncluding heterogeneous nuclear ribonucleoproteins (hnRNPs).roteins implicated in regulation of alternative splicing.nd protein components of small nuclear ribonucleoproteins (snRNPs). The RRM in heterodimeric splicing factor U2 snRNP auxiliary factor (U2AF) appears to have two RRM-like domains with specialized features for protein recognition . The motif also appears in a few single stranded DNA binding proteins. The RRM structure consists of four strands and two helices arranged in an alpha/beta sandwich.ith a third helix present during RNA binding in some cases .
  IPR000504:RNA-binding region RNP-1 (RNA recognition motif)
These sequences represent a subfamily of RNA splicing factors including the Pad-1 protein (Neurospora crassa).APER (mouse) and CC1.3 (human). All are characterised by an N-terminal arginine-rich.ow complexity domain followed by three (or in the case of 4 human paralogs.wo) RNA recognition domains. These splicing factors are closely related to the U2AF splicing factor family ().
  IPR006509:Splicing factor, CC1-like
This entry represents nucleotide-binding domains with an alpha-beta plait structure.hich consists of either a ferredoxin-like (beta-alpha-beta)2 fold.uch as that found in RNA-binding domains of various ribonucleoproteins or in viral DNA-binding domains . or a beta-(alpha)-beta-alpha-beta(2) fold.uch as that found in the ribosomal protein L23 .
  IPR012677:Nucleotide-binding, alpha-beta plait
IPR000504:RRM 
Evalue:-30.7958800173441 
Location:264-337IPR000504:RRM 
Evalue:-14.1549019599857 
Location:167-239
SequencesProtein: RBM23_HUMAN (439 aa)
mRNA: AL834198 BX161440 NM_018107
Local Annotation
Synapse Ontology
Calcium release from RyR (Ryanodine Receptor) in the SR (Sarcoplasmic Reticulum) is activated by the calcium induced-calcium-release
sdb:0325 RyR-CICR  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 346 residues, 22439745-22440782Exon2: 25 residues, 22440862-22440932Exon3: 42 residues, 22441028-22441148Exon4: 67 residues, 22441235-22441431Exon5: 24 residues, 22443309-22443375Exon6: 48 residues, 22443923-22444061Exon7: 53 residues, 22444142-22444295Exon8: 41 residues, 22444384-22444502Exon9: 20 residues, 22444654-22444708Exon10: 60 residues, 22445243-22445417Exon11: 18 residues, 22447381-22447429Exon12: 39 residues, 22448531-22448644Exon13: 27 residues, 22450376-22450452Exon14: 42 residues, 22458047-22458169Exon15: 2 residues, -Jump to RBM23_HUMANExon1: 323 residues, 22439816-22440782Exon2: 25 residues, 22440862-22440932Exon3: 42 residues, 22441028-22441148Exon4: 67 residues, 22441235-22441431Exon5: 24 residues, 22443309-22443375Exon6: 48 residues, 22443923-22444061Exon7: 53 residues, 22444142-22444295Exon8: 41 residues, 22444384-22444502Exon9: 20 residues, 22444654-22444708Exon10: 60 residues, 22445243-22445417Exon11: 39 residues, 22448531-22448644Exon12: 27 residues, 22450376-22450452Exon13: 57 residues, 22458047-22458214Exon14: 2 residues, -Jump to RBM23_HUMANExon1: 323 residues, 22439816-22440782Exon2: 25 residues, 22440862-22440932Exon3: 42 residues, 22441028-22441148Exon4: 670 residues, 22441235-22443239Exon5: 24 residues, 22443309-22443375Exon6: 48 residues, 22443923-22444061Exon7: 53 residues, 22444142-22444295Exon8: 41 residues, 22444384-22444502Exon9: 20 residues, 22444654-22444708Exon10: 60 residues, 22445243-22445417Exon11: 18 residues, 22447381-22447429Exon12: 39 residues, 22448531-22448644Exon13: 27 residues, 22450376-22450452Exon14: 48 residues, 22458047-22458185Exon15: 2 residues, -Jump to RBM23_HUMAN  
Tune and view alternative isoforms
Loci Cluster (Details)Loci: 4116 22525950-22549192 ~-23K 10843(C14orf93)(-)Loci: 4117 22597615-22634663 ~-37K 10853(ACIN1)(-)Loci: 2824 22845875-22850798 ~-5K 10860(BCL2L2)(+)Loci: 2825 22859236-22865202 ~-6K 10861(PABPN1)(+)Loci: 4118 22895451-22904682 ~-9K 10864(EFS)(-)Loci: 4119 22921038-22947324 ~-26K 10871(MYH6)(-)Loci: 4120 22951789-22973312 ~-22K 10872(MYH7)(-)Loci: 4121 23059904-23065839 ~-6K 10876(ZFHX2)(-)Loci: 4122 23098616-23107119 ~-9K 10881(AP1G2)(-)Loci: 4115 22439745-22458214 ~-18K 10832(RBM23)(-)Link out to UCSC