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0RB40B_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameRAB40B
DescriptionRas-related protein rab-40b (socs box containing protein rar) (rar protein).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GON/A
Domain Architecture (Details)
InterPro domains assigned to SynO:
Small GTPases are involved in intracellular cell signalling processes. The Ras family includes a large number of small GTPases. Members of the Rab GTPases subfamily have been implicated in vesicle trafficking.The crystal structure of a number of the members of this entry have been determined: .ab GDP-dissociation inhibitor in complex with prenylated YPT1 GTPase . .ec4 ..ab5a .
  IPR003579:Ras small GTPase, Rab type
InterPro domains unassigned to SynO:
Many members of the Ras superfamily of GTPases have been implicated in the regulation of hematopoietic cells.ith roles in growth.urvival.ifferentiation.ytokine production.hemotaxis.esicle-trafficking.nd phagocytosis. The Ras superfamily of proteins now includes over 150 small GTPases (distinguished from the large.eterotrimeric GTPases.he G-proteins). It comprises six subfamilies.he Ras.ho.an.ab.rf.nd Kir/Rem/Rad subfamilies . They exhibit remarkable overall amino acid identities.specially in the regions interacting with the guanine nucleotide exchange factors that catalyze their activation .
  IPR013753:Ras
The SOCS box was first identified in SH2-domain-containing proteins of the suppressor of cytokines signaling (SOCS) family but was later also found in:the WSB (WD-40-repeat-containing proteins with a SOCS box) family.he SSB (SPRY domain-containing proteins with a SOCS box) family.he ASB (ankyrin-repeat-containing proteins with a SOCS box) family.nd ras and ras-like GTPases .The SOCS box found in these proteins is an about 50 amino acid carboxy-terminal domain composed of two blocks of well-conserved residues separated by between 2 and 10 nonconserved residues . The C-terminal conserved region is an L/P-rich sequence of unknown function.hereas the N-terminal conserved region is a consensus BC box .hich binds to the Elongin BC complex . It has been proposed that this association could couple bound proteins to the ubiquitination or proteasomal compartments .
  IPR001496:SOCS protein, C-terminal
Many members of the Ras superfamily of GTPases have been implicated in the regulation of hematopoietic cells.ith roles in growth.urvival.ifferentiation.ytokine production.hemotaxis.esicle-trafficking.nd phagocytosis. The Ras superfamily of proteins now includes over 150 small GTPases (distinguished from the large.eterotrimeric GTPases.he G-proteins). It comprises six subfamilies.he Ras.ho.an.ab.rf.nd Kir/Rem/Rad subfamilies . They exhibit remarkable overall amino acid identities.specially in the regions interacting with the guanine nucleotide exchange factors that catalyze their activation .
  IPR001806:Ras GTPase
Proteins with a small GTP-binding domain include Ras.hoA.ab11.ranslation elongation factor G.ranslation initiation factor IF-2.etratcycline resistance protein TetM.DC42.ra.DP-ribosylation factors.dhF.nd many others . In some proteins the domain occurs more than once. Among them there is a large number of small GTP-binding proteins and related domains in larger proteins. Note that the alpha chains of heterotrimeric G proteins are larger proteins in which the NKXD motif is separated from the GxxxxGK[ST] motif (P-loop) by a long insert and are not easily detected by this model.
  IPR005225:Small GTP-binding protein domain
IPR003579:RAB 
Evalue:-78.0604807473814 
Location:15-177IPR001496:SOCS 
Evalue:-16.5528419686578 
Location:183-226
SequencesProtein: RB40B_HUMAN (278 aa)
mRNA: NM_006822
Local Annotation
Synapse Ontology
transport of vesicles in the presynaptic neuron
sdb:0017 Mobilization: synapsins, CAM kinase I  (Evidence:domains)
KO assignmentK07927
  Level 3 annotation:
    RAB40B, member Ras oncogene family
  Level 2 annotation:
    GTP-binding proteins
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 355 residues, 78208237-78209299Exon2: 76 residues, 78209655-78209878Exon3: 28 residues, 78210744-78210822Exon4: 22 residues, 78212151-78212212Exon5: 22 residues, 78215660-78215721Exon6: 63 residues, 78249619-78249802Exon7: 2 residues, -Jump to RB40B_HUMAN  
Tune and view alternative isoforms
Loci Cluster (Details)Loci: 4323 76816673-76827450 ~-11K 16811(-)Loci: 4324 77091593-77094422 ~-3K 16823(ACTG1)(-)Loci: 3047 77261424-77279550 ~-18K 16838(HGS)(+)Loci: 3048 77451912-77454066 ~-2K 16852(NPB)(+)Loci: 3049 77603051-77608635 ~-6K 16881(GPS1)(+)Loci: 4325 77629503-77649395 ~-20K 16888(FASN)(-)Loci: 4326 77795530-77824862 ~-29K 16893(CSNK1D)(-)Loci: 4327 78208237-78249802 ~-42K 16919(RAB40B)(-)Loci: 3046 76623556-76705827 ~-82K 16801(BAIAP2)(+)Link out to UCSC