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0RB22A_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameRAB22A
DescriptionRas-related protein rab-22a (rab-22).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005769 early endosome (IDA)
0005886 plasma membrane (IDA)
0005525 GTP binding (TAS)
0003924 GTPase activity (TAS)
0005515 protein binding (IPI)
0006897 endocytosis (IDA)
0007032 endosome organization and biogenesis (IEP)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains assigned to SynO:
Small GTPases are involved in intracellular cell signalling processes. The Ras family includes a large number of small GTPases. Members of the Rab GTPases subfamily have been implicated in vesicle trafficking.The crystal structure of a number of the members of this entry have been determined: .ab GDP-dissociation inhibitor in complex with prenylated YPT1 GTPase . .ec4 ..ab5a .
  IPR003579:Ras small GTPase, Rab type
InterPro domains unassigned to SynO:
Many members of the Ras superfamily of GTPases have been implicated in the regulation of hematopoietic cells.ith roles in growth.urvival.ifferentiation.ytokine production.hemotaxis.esicle-trafficking.nd phagocytosis. The Ras superfamily of proteins now includes over 150 small GTPases (distinguished from the large.eterotrimeric GTPases.he G-proteins). It comprises six subfamilies.he Ras.ho.an.ab.rf.nd Kir/Rem/Rad subfamilies . They exhibit remarkable overall amino acid identities.specially in the regions interacting with the guanine nucleotide exchange factors that catalyze their activation .
  IPR013753:Ras
Many members of the Ras superfamily of GTPases have been implicated in the regulation of hematopoietic cells.ith roles in growth.urvival.ifferentiation.ytokine production.hemotaxis.esicle-trafficking.nd phagocytosis. The Ras superfamily of proteins now includes over 150 small GTPases (distinguished from the large.eterotrimeric GTPases.he G-proteins). It comprises six subfamilies.he Ras.ho.an.ab.rf.nd Kir/Rem/Rad subfamilies . They exhibit remarkable overall amino acid identities.specially in the regions interacting with the guanine nucleotide exchange factors that catalyze their activation .
  IPR001806:Ras GTPase
Proteins with a small GTP-binding domain include Ras.hoA.ab11.ranslation elongation factor G.ranslation initiation factor IF-2.etratcycline resistance protein TetM.DC42.ra.DP-ribosylation factors.dhF.nd many others . In some proteins the domain occurs more than once. Among them there is a large number of small GTP-binding proteins and related domains in larger proteins. Note that the alpha chains of heterotrimeric G proteins are larger proteins in which the NKXD motif is separated from the GxxxxGK[ST] motif (P-loop) by a long insert and are not easily detected by this model.
  IPR005225:Small GTP-binding protein domain
IPR013753:Ras 
Evalue:-76.5228805541992 
Location:7-168
SequencesProtein: RB22A_HUMAN (194 aa)
mRNA: NM_020673
Local Annotation
Synapse Ontology
transport of vesicles in the presynaptic neuron
sdb:0017 Mobilization: synapsins, CAM kinase I  (Evidence:keywords,domains)
endosome of the presynaptic compartment. A cellular structure that is involved in the transport of proteins in the neuron after the proteins are endocytosed from the outside to the inside of the cell.
sdb:0088 endosome  (Evidence:keywords,domains)
KO assignmentK07891
  Level 3 annotation:
    RAB22A, member Ras oncogene family
  Level 2 annotation:
    GTP-binding proteins
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 100 residues, 56318176-56318474Exon2: 28 residues, 56319504-56319584Exon3: 29 residues, 56352179-56352261Exon4: 26 residues, 56361734-56361806Exon5: 37 residues, 56361893-56362000Exon6: 38 residues, 56362617-56362727Exon7: 2635 residues, 56368067-56375966Exon8: 2 residues, -Jump to RB22A_HUMAN  
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Loci Cluster (Details)Loci: 3271 56397650-56455367 ~-58K 23407(VAPB)(+)Loci: 3272 56659733-56687986 ~-28K 23415(STX16)(+)Loci: 3273 56701326-56723873 ~-23K 23419(NPEPL1)(+)Loci: 3274 56989705-57003581 ~-14K 23432(TH1L)(+)Loci: 3275 57027703-57035102 ~-7K 23436(TUBB1)(+)Loci: 3270 56318176-56375966 ~-58K 23405(RAB22A)(+)Link out to UCSC