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0RAP1A_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameRAP1A
DescriptionRas-related protein rap-1a (gtp-binding protein smg-p21a) (ras-related protein krev-1) (c21kg) (g-22k).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005515 protein binding (IPI)
Domain Architecture (Details)
InterPro domains unassigned to SynO:
Ras proteins are small GTPases that regulate cell growth.roliferation and differentiation. The different Ras isoforms H-ras.-ras and K-ras generate distinct signal outputs.espite interacting with a common set of activators and effectors. Ras is activated by guanine nucleotide exchange factors (GEFs) that release GDP and allow GTP binding. Many RasGEFs have been identified. These are sequestered in the cytosol until activation by growth factors triggers recruitment to the plasma membrane or Golgi.here the GEF colocalizes with Ras. Active GTP-bound Ras interacts with several effector proteins: among the best characterized are the Raf kinases.hosphatidylinositol 3-kinase (PI3K).alGEFs and NORE/MST1. Ras proteins are synthesized as cytosolic precursors that undergo post-translational processing to be able to associate with cell membranes . First.rotein farnesyl transferase. cytosolic enzyme.ttaches a farnesyl group to the cysteine residue of the CAAX motif. Second.he farnesylated CAAX sequence targets Ras to the cytosolic surface of the ER where an endopeptidase removes the AAX tripeptide. Third.he alpha-carboxyl group on the now carboxy-terminal farnesylcysteine is methylated by isoprenylcysteine carboxyl methyltransferase. Finally.fter methylation.as proteins take one of two routes to the cell surface.hich is dictated by a second targeting signal that is located immediately amino-terminal to the farnesylated cysteine. N-ras and H-ras are expressed stably on the plasma membrane.n Golgi in transfected cells.nd at least transiently on the ER. Ras has also been visualized on endosomes.
  IPR003577:Ras small GTPase, Ras type
Many members of the Ras superfamily of GTPases have been implicated in the regulation of hematopoietic cells.ith roles in growth.urvival.ifferentiation.ytokine production.hemotaxis.esicle-trafficking.nd phagocytosis. The Ras superfamily of proteins now includes over 150 small GTPases (distinguished from the large.eterotrimeric GTPases.he G-proteins). It comprises six subfamilies.he Ras.ho.an.ab.rf.nd Kir/Rem/Rad subfamilies . They exhibit remarkable overall amino acid identities.specially in the regions interacting with the guanine nucleotide exchange factors that catalyze their activation .
  IPR013753:Ras
Many members of the Ras superfamily of GTPases have been implicated in the regulation of hematopoietic cells.ith roles in growth.urvival.ifferentiation.ytokine production.hemotaxis.esicle-trafficking.nd phagocytosis. The Ras superfamily of proteins now includes over 150 small GTPases (distinguished from the large.eterotrimeric GTPases.he G-proteins). It comprises six subfamilies.he Ras.ho.an.ab.rf.nd Kir/Rem/Rad subfamilies . They exhibit remarkable overall amino acid identities.specially in the regions interacting with the guanine nucleotide exchange factors that catalyze their activation .
  IPR001806:Ras GTPase
Proteins with a small GTP-binding domain include Ras.hoA.ab11.ranslation elongation factor G.ranslation initiation factor IF-2.etratcycline resistance protein TetM.DC42.ra.DP-ribosylation factors.dhF.nd many others . In some proteins the domain occurs more than once. Among them there is a large number of small GTP-binding proteins and related domains in larger proteins. Note that the alpha chains of heterotrimeric G proteins are larger proteins in which the NKXD motif is separated from the GxxxxGK[ST] motif (P-loop) by a long insert and are not easily detected by this model.
  IPR005225:Small GTP-binding protein domain
IPR003577:RAS 
Evalue:-119.568636235841 
Location:1-168
SequencesProtein: RAP1A_HUMAN (184 aa)
mRNA: NM_001010935
Local Annotation
Synapse Ontology
transport of vesicles in the presynaptic neuron
sdb:0017 Mobilization: synapsins, CAM kinase I  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 51 residues, 111963927-111964079Exon2: 33 residues, 111971614-111971708Exon3: 30 residues, 112035478-112035562Exon4: 25 residues, 112039485-112039554Exon5: 21 residues, 112041585-112041642Exon6: 49 residues, 112047480-112047621Exon7: 50 residues, 112048487-112048631Exon8: 40 residues, 112053293-112053409Exon9: 351 residues, 112056575-112057623Exon10: 2 residues, -Jump to RAP1A_HUMAN  
Tune and view alternative isoforms
Loci Cluster (Details)Loci: 3819 111843577-111848266 ~-5K 2174(ADORA3)(-)Loci: 2538 111963927-112057623 ~-94K 2175(RAP1A)(+)Loci: 2539 112099776-112111721 ~-12K 2178(DDX20)(+)Loci: 3820 112119976-112333300 ~-213K 2180(KCND3)(-)Loci: 2537 111793265-111806046 ~-13K 2169(ATP5F1)(+)Link out to UCSC