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0RAN_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameRAN
DescriptionGtp-binding nuclear protein ran (gtpase ran) (ras-like protein tc4) (androgen receptor-associated protein 24).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005737 cytoplasm (IDA)
0005643 nuclear pore (NAS)
0050681 androgen receptor binding (NAS)
0003682 chromatin binding (TAS)
0005525 GTP binding (IDA)
0003924 GTPase activity (TAS)
0005515 protein binding (IPI)
0003713 transcription coactivator activity (NAS)
0030521 androgen receptor signaling pathway (NAS)
0006259 DNA metabolism (TAS)
0007052 mitotic spindle organization and biogenesis (TAS)
0045893 positive regulation of transcription, DNA-d... (NAS)
0006611 protein-nucleus export (NAS)
0000074 regulation of progression through cell cycle (NAS)
0006405 RNA-nucleus export (NAS)
0007165 signal transduction (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
Many members of the Ras superfamily of GTPases have been implicated in the regulation of hematopoietic cells.ith roles in growth.urvival.ifferentiation.ytokine production.hemotaxis.esicle-trafficking.nd phagocytosis. The Ras superfamily of proteins now includes over 150 small GTPases (distinguished from the large.eterotrimeric GTPases.he G-proteins). It comprises six subfamilies.he Ras.ho.an.ab.rf.nd Kir/Rem/Rad subfamilies . They exhibit remarkable overall amino acid identities.specially in the regions interacting with the guanine nucleotide exchange factors that catalyze their activation .
  IPR013753:Ras
Many members of the Ras superfamily of GTPases have been implicated in the regulation of hematopoietic cells.ith roles in growth.urvival.ifferentiation.ytokine production.hemotaxis.esicle-trafficking.nd phagocytosis. The Ras superfamily of proteins now includes over 150 small GTPases (distinguished from the large.eterotrimeric GTPases.he G-proteins). It comprises six subfamilies.he Ras.ho.an.ab.rf.nd Kir/Rem/Rad subfamilies . They exhibit remarkable overall amino acid identities.specially in the regions interacting with the guanine nucleotide exchange factors that catalyze their activation .
  IPR001806:Ras GTPase
Ran (or TC4).s an evolutionary conserved member of the Ras superfamily of small GTPases that regulates all receptor-mediated transport between the nucleus and the cytoplasm. Ran has been implicated in a large number of processes including nucleocytoplasmic transport.NA synthesis.rocessing and export and cell cycle checkpoint control . Ran plays a crucial role in both import/export pathways and determines the directionality of nuclear transport. Import receptors bind their cargos in the cytoplasm where the concentration of RanGTP is low and release their cargos in the nucleus where the concentration of RanGTP is high . Export receptors respond to Ran GTP in the opposite manner. Furthermore.t has been shown that nuclear transport factor 2 (NTF2. stimulates efficient nuclear import of a cargo protein. NTF2 binds specifically to RanGDP and also to the FXFG repeat containing nucleoporins . Ran is generally included in the RAS superfamily of small GTP-bindingproteins .ut it is only slightly related to the other RAS proteins. Italso differs from RAS proteins in that it lacks cysteine residues at its C-terminal and is therefore not subject to prenylation. Instead Ran has anacidic C-terminus. It is.owever similar to RAS family members in requiring aspecific guanine nucleotide exchange factor (GEF) and a specific GTPaseactivating protein (GAP) as stimulators of overall GTPase activity. Ran consists of a core domain that is structurally similar to the GTP-binding domains of other small GTPases but.n addition.an has aC-terminal extension consisting of an unstructured linker and a 16 residue alpha-helix that is located opposite the "Switch I" regionin the RanGDP structure . Three regions of Ran change conformation depending on the nucleotide bound.he Switch I and II regions.hich interact withthe bound nucleotide.s well as the C-terminal extension. In RanGDP.he C-terminal extension contacts the core of the protein.hile in RanGTP.he extension is extending away from the core.ost likely due to a steric clash between the switch I region and the linker part of the C-terminal extension. This suggests that the C-terminal extension in RanGDP is crucial for shielding residues in the core domain and preventing the switch regions fromadopting a GTP-like form. This prevents binding of transport factors to RanGDP that would otherwise lead to uncoordinated interaction between importin beta-likeproteins and cellular factors.
  IPR002041:GTP-binding nuclear protein Ran
IPR002041:RAN 
Evalue:-173.251815795898 
Location:15-215
SequencesProtein: RAN_HUMAN (216 aa)
mRNA: NM_006325
Local Annotation
Synapse Ontology
Typical ecretory organelles, some 50 nm in diameter, of presynaptic nerve terminals; accumulate high concentrations of nonpeptide neurotransmitters and secrete these into the synaptic cleft by fusion with the 'active zone' of the presynaptic plasma membrane.
sdb:0094 typical synaptic vesicle  (Evidence:keywords)
Various stages of the synaptic vesicle cycle, including attachment, prefusion, triggering, recycling and reloading of the vesicles with transmitter.
sdb:0098 synaptic vesicle cycling  (Evidence:keywords)
KO assignmentK07936
  Level 3 annotation:
    RAN, member Ras oncogene family
  Level 2 annotation:
    GTP-binding proteins
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 35 residues, 129922520-129922624Exon2: 17 residues, 129923081-129923127Exon3: 30 residues, 129923333-129923418Exon4: 44 residues, 129923500-129923626Exon5: 64 residues, 129925043-129925231Exon6: 59 residues, 129926109-129926280Exon7: 314 residues, 129926379-129927316Exon8: 2 residues, -Jump to RAN_HUMAN  
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Loci Cluster (Details)Loci: 2800 129922520-129927316 ~-5K 10021(RAN)(+)Loci: 2801 130004789-130189786 ~-185K 10023(GPR133)(+)Loci: 4085 129840101-129889764 ~-50K 10020(EPIM)(-)Link out to UCSC