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0RAI3_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameGPRC5A
DescriptionRetinoic acid-induced protein 3 (g-protein coupled receptor family c group 5 member a) (retinoic acid-induced gene 1 protein) (raig-1) (orphan g-protein coupling receptor peig-1).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005887 integral to plasma membrane (TAS)
0004930 G-protein coupled receptor activity (TAS)
0007165 signal transduction (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
G-protein-coupled receptors.PCRs.onstitute a vast protein family that encompasses a wide range of functions (including various autocrine.aracrine and endocrine processes). They show considerable diversity at the sequence level.n the basis of which they can be separated into distinct groups. We use the term clan to describe the GPCRs.s they embrace a group of families for which there are indications of evolutionary relationship.ut between which there is no statistically significant similarity in sequence . The currently known clan members include the rhodopsin-like GPCRs.he secretin-like GPCRs.he cAMP receptors.he fungal mating pheromone receptors.nd the metabotropic glutamate receptor family. There is a specialized database for GPCRs: http://www.gpcr.org/7tm/. The metabotropic glutamate receptors are functionally and pharmacologically distinct from the ionotropic glutamate receptors. They are coupled to G-proteins and stimulate the inositol phosphate/Ca2+ intracellular signalling pathway . The amino acid sequences of the receptors contain high proportions of hydrophobic residues grouped into 7 domains.n a manner reminiscent of the rhodopsins and other receptors believed to interact with G-proteins. However.hile a similar 3D framework has been proposed to account for this.here is no significant sequence identity between these and receptors of the rhodopsin-type family: the metabotropic glutamate receptors thus bear their own distinctive 7TM signature. This 7TM signature is also shared by the calcium-sensing receptors.nd GABA (gamma-amino-butyric acid) type B (GABA(B)) receptors.
  IPR000337:GPCR, family 3, metabotropic glutamate receptor-like
IPR000337:7tm_3 
Evalue:-7.28399658203125 
Location:31-273IPR000337:G_PROTEIN_RECEP_F3_1 
Evalue:0 
Location:0-0
SequencesProtein: RAI3_HUMAN (357 aa)
mRNA: NM_003979
Local Annotation
Synapse Ontology
the mechanism by which the restiong potential is held.
sdb:0288 maintain membrane potential  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 215 residues, 12935222-12935865Exon2: 311 residues, 12952443-12953372Exon3: 21 residues, 12956284-12956343Exon4: 408 residues, 12956647-12957865Exon5: 2 residues, -Jump to RAI3_HUMAN  
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Loci Cluster (Details)Loci: 2739 12935222-12957865 ~-23K 8455(GPRC5A)(+)Loci: 2738 12656097-12689308 ~-33K 8446(+)Link out to UCSC