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0RAD17_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameRAD17
DescriptionCell cycle checkpoint protein rad17 (hrad17) (rf-c/activator 1 homolog).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GON/A
Domain Architecture (Details)
InterPro domains unassigned to SynO:
To be effective as a mechanism that preserves genomic integrity.he DNA damage checkpoint must beextremely sensitive in its ability to detect DNA damage. In Saccharomyces cerevisiae the Ddc1/Rad17/Mec3 complex and Rad24 are DNA damage checkpoint components which may promote checkpointactivation by "sensing" DNA damage directly . Rad24 shares sequence homology with RF-c. protein that recognizes DNA template/RNA primer hybrids during DNA replication. TheDdc1 complex has structural homology to proliferating-cell nuclear antigen (PCNA).hich clamps ontoDNA and confers processivity to DNA polymerases delta and epsilon. Rad24 is postulated torecognize DNA lesions and then recruit the Ddc1 complex to generate checkpoint signals.
  IPR004582:Checkpoint protein Rad24
AAA ATPases form a large.unctionally diverse protein family belonging to the AAA+ superfamily of ring-shaped P-loop NTPases.hich exert their activity through the energy-dependent unfolding of macromolecules. AAA ATPases contain a P-loop NTPase domain.hich is the most abundant class of NTP-binding protein fold.nd is found throughout all kingdoms of life . P-loop NTPase domains act to hydrolyse the beta-gamma phosphate bond of bound nucleoside triphosphate. There are two classes of P-loop domains: the KG (kinase-GTPase) division.nd the ASCE division.he latter including the AAA+ group as well as several other ATPases.There are at least six major clades of AAA domains (metalloproteases.eiotic proteins.1 and D2 domains of ATPases with two AAA domains.roteasome subunits.nd BSC1).s well as several minor clades.ome of which consist of hypothetical proteins . The domain organisation of AAA ATPases consists of a non-ATPase N-terminal domain that acts in substrate recognition.ollowed by one or two AAA domains (D1 and D2).ne of which may be degenerate.
  IPR003593:AAA ATPase
IPR004582:Rad17 
Evalue:-1e+125 
Location:83-593
SequencesProtein: RAD17_HUMAN (681 aa)
mRNA: NM_133338 NM_133339
Local Annotation
Synapse Ontology
transport of vesicles in the presynaptic neuron
sdb:0017 Mobilization: synapsins, CAM kinase I  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 41 residues, 160403-160525Exon2: 47 residues, 161626-161763Exon3: 36 residues, 162042-162146Exon4: 63 residues, 162622-162806Exon5: 88 residues, 164411-164669Exon6: 30 residues, 165209-165293Exon7: 54 residues, 172682-172839Exon8: 47 residues, 175578-175715Exon9: 19 residues, 176824-176877Exon10: 44 residues, 176961-177087Exon11: 25 residues, 177177-177247Exon12: 39 residues, 179816-179928Exon13: 63 residues, 182615-182798Exon14: 30 residues, 183939-184025Exon15: 51 residues, 184138-184285Exon16: 52 residues, 187188-187338Exon17: 42 residues, 190846-190967Exon18: 21 residues, 201304-201362Exon19: 258 residues, 204849-205618Exon20: 2 residues, -Jump to RAD17_HUMANExon1: 35 residues, 162042-162146Exon2: 88 residues, 164411-164669Exon3: 30 residues, 165209-165293Exon4: 54 residues, 172682-172839Exon5: 47 residues, 175578-175715Exon6: 19 residues, 176824-176877Exon7: 44 residues, 176961-177087Exon8: 25 residues, 177177-177247Exon9: 39 residues, 179816-179928Exon10: 63 residues, 182615-182798Exon11: 30 residues, 183939-184025Exon12: 51 residues, 184138-184285Exon13: 52 residues, 187188-187338Exon14: 42 residues, 190846-190967Exon15: 21 residues, 201304-201362Exon16: 258 residues, 204849-205618Exon17: 2 residues, -Jump to RAD17_HUMANLoci index, Chromosomal location, Length, Possible relational loci clusterExon1: 41 residues, 68701394-68701516Exon2: 47 residues, 68702617-68702754Exon3: 36 residues, 68703036-68703140Exon4: 63 residues, 68703616-68703800Exon5: 88 residues, 68705412-68705670Exon6: 30 residues, 68706210-68706294Exon7: 54 residues, 68713483-68713640Exon8: 47 residues, 68716379-68716516Exon9: 19 residues, 68717625-68717678Exon10: 44 residues, 68717762-68717888Exon11: 25 residues, 68717978-68718048Exon12: 39 residues, 68720616-68720728Exon13: 63 residues, 68723413-68723596Exon14: 30 residues, 68724737-68724823Exon15: 51 residues, 68724936-68725083Exon16: 52 residues, 68727979-68728129Exon17: 42 residues, 68731631-68731752Exon18: 21 residues, 68742075-68742133Exon19: 258 residues, 68745613-68746382Exon20: 2 residues, -Jump to RAD17_HUMANExon1: 35 residues, 68703036-68703140Exon2: 88 residues, 68705412-68705670Exon3: 30 residues, 68706210-68706294Exon4: 54 residues, 68713483-68713640Exon5: 47 residues, 68716379-68716516Exon6: 19 residues, 68717625-68717678Exon7: 44 residues, 68717762-68717888Exon8: 25 residues, 68717978-68718048Exon9: 39 residues, 68720616-68720728Exon10: 63 residues, 68723413-68723596Exon11: 30 residues, 68724737-68724823Exon12: 51 residues, 68724936-68725083Exon13: 52 residues, 68727979-68728129Exon14: 42 residues, 68731631-68731752Exon15: 21 residues, 68742075-68742133Exon16: 258 residues, 68745613-68746382Exon17: 2 residues, -Jump to RAD17_HUMAN  
Loci Cluster (Details)Loci: 3515 393545-449737 ~-56K 30164(BIRC1)(+)Loci: 4764 465177-493242 ~-28K 30167(SMN1)(-)Loci: 4765 499652-517517 ~-18K 30169(SERF1A)(-)Loci: 4766 621245-720436 ~-99K 30171(SMA3)(-)Loci: 3514 160403-205618 ~-45K 30155(RAD17)(+)Link out to UCSC