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0RABE2_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameRABEP2
DescriptionRab gtpase binding effector protein 2 (rabaptin-5beta).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GON/A
Domain Architecture (Details)
InterPro domains assigned to SynO:
Regeneration of injured axons at neuromuscular junctions has been assumedto be regulated by extra-cellular factors that promote neurite outgrowth.A novel neurite outgrowth factor from chick denervated skeletal muscle has been cloned and characterised. The protein.ermed neurocrescin (rabaptin).as been shown to be secreted in an activity-dependent fashion .Rabaptin is a 100kDa coiled-coil protein that interacts with the GTP form of the small GTPase Rab5. potent regulator of endocytic transport . It is mainly cytosolic.ut a fraction co-localises with Rab5 to early endosomes. Rab5 recruits rabaptin-5 to purified early endosomes in aGTP-dependent manner.emonstrating functional similarities with other members of the Ras superfamily. Immunodepletion of rabaptin-5 from cytosol strongly inhibits Rab5-dependent early endosome fusion. Thus.abaptin-5 is a Rab effector required for membrane docking and fusion.
  IPR003914:Rabaptin
IPR003914:Rabaptin 
Evalue:-64.6575775146484 
Location:47-167IPR000183:ODR_DC_2_2 
Evalue:0 
Location:231-244
SequencesProtein: RABE2_HUMAN (569 aa)
mRNA: AK092299
Local Annotation
Synapse Ontology
endosome of the presynaptic compartment. A cellular structure that is involved in the transport of proteins in the neuron after the proteins are endocytosed from the outside to the inside of the cell.
sdb:0088 endosome  (Evidence:keywords,domains)
attachment of the vesicle filled with transmitters involves a specific interaction between the vesicle membrane and the presynaptic active zone.
sdb:0148 docking  (Evidence:keywords,domains)
synaptic vesicles fuse with early endosomes as an intermediate sorting compartment to eliminate aged or missorted proteins.
sdb:0159 endosome fusion  (Evidence:keywords,domains)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 208 residues, 28823243-28823866Exon2: 41 residues, 28824218-28824335Exon3: 20 residues, 28824525-28824581Exon4: 6 residues, 28824688-28824700Exon5: 61 residues, 28824840-28825018Exon6: 54 residues, 28827430-28827586Exon7: 35 residues, 28829709-28829808Exon8: 34 residues, 28829905-28830001Exon9: 119 residues, 28833057-28833408Exon10: 39 residues, 28833493-28833604Exon11: 54 residues, 28838607-28838765Exon12: 73 residues, 28843224-28843437Exon13: 218 residues, 28843924-28844574Exon14: 2 residues, -Jump to RABE2_HUMAN  
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Loci Cluster (Details)Loci: 4216 28524418-28528150 ~-4K 13803(SULT1A1)(-)Loci: 2931 28797309-28823331 ~-26K 13823(ATP2A1)(+)Loci: 4217 28823243-28844574 ~-21K 13826(RABEP2)(-)Loci: 4215 28510766-28515302 ~-5K 13802(SULT1A2)(-)Link out to UCSC