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0RABE1_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameRABEP1
DescriptionRab gtpase binding effector protein 1 (rabaptin-5) (rabaptin-5alpha) (rabaptin-4).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005769 early endosome (TAS)
0005515 protein binding (IPI)
0006897 endocytosis (TAS)
0006944 membrane fusion (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains assigned to SynO:
Regeneration of injured axons at neuromuscular junctions has been assumedto be regulated by extra-cellular factors that promote neurite outgrowth.A novel neurite outgrowth factor from chick denervated skeletal muscle has been cloned and characterised. The protein.ermed neurocrescin (rabaptin).as been shown to be secreted in an activity-dependent fashion .Rabaptin is a 100kDa coiled-coil protein that interacts with the GTP form of the small GTPase Rab5. potent regulator of endocytic transport . It is mainly cytosolic.ut a fraction co-localises with Rab5 to early endosomes. Rab5 recruits rabaptin-5 to purified early endosomes in aGTP-dependent manner.emonstrating functional similarities with other members of the Ras superfamily. Immunodepletion of rabaptin-5 from cytosol strongly inhibits Rab5-dependent early endosome fusion. Thus.abaptin-5 is a Rab effector required for membrane docking and fusion.
  IPR003914:Rabaptin
IPR003914:Rabaptin 
Evalue:-100.08618927002 
Location:450-600IPR003914:Rabaptin 
Evalue:-57.6020584106445 
Location:89-199IPR003914:RABAPTIN 
Evalue:0 
Location:624-646IPR003914:RABAPTIN 
Evalue:0 
Location:230-251IPR003914:RABAPTIN 
Evalue:0 
Location:676-696IPR003914:RABAPTIN 
Evalue:0 
Location:11-30IPR003914:RABAPTIN 
Evalue:0 
Location:417-435IPR003914:RABAPTIN 
Evalue:0 
Location:367-384
SequencesProtein: RABE1_HUMAN (862 aa)
mRNA: X91141
Local Annotation
Synapse Ontology
endosome of the presynaptic compartment. A cellular structure that is involved in the transport of proteins in the neuron after the proteins are endocytosed from the outside to the inside of the cell.
sdb:0088 endosome  (Evidence:keywords,domains)
attachment of the vesicle filled with transmitters involves a specific interaction between the vesicle membrane and the presynaptic active zone.
sdb:0148 docking  (Evidence:keywords,domains)
synaptic vesicles fuse with early endosomes as an intermediate sorting compartment to eliminate aged or missorted proteins.
sdb:0159 endosome fusion  (Evidence:keywords,domains)
?
sdb:0329 actin in synaptic vesicle cycling  (Evidence:keywords,domains)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 75 residues, 5126316-5126539Exon2: 45 residues, 5152712-5152841Exon3: 70 residues, 5175967-5176171Exon4: 55 residues, 5179202-5179363Exon5: 42 residues, 5182037-5182157Exon6: 47 residues, 5190808-5190944Exon7: 61 residues, 5194469-5194648Exon8: 46 residues, 5198377-5198509Exon9: 158 residues, 5205226-5205694Exon10: 37 residues, 5206930-5207035Exon11: 41 residues, 5209140-5209257Exon12: 35 residues, 5212388-5212487Exon13: 49 residues, 5217332-5217473Exon14: 65 residues, 5221134-5221324Exon15: 20 residues, 5222195-5222251Exon16: 35 residues, 5224382-5224481Exon17: 41 residues, 5225407-5225524Exon18: 98 residues, 5227140-5227430Exon19: 2 residues, -Jump to RABE1_HUMAN  
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Loci Cluster (Details)Loci: 2970 4657391-4673694 ~-16K 14928(PLD2)(+)Loci: 4256 4741839-4747148 ~-5K 14931(CHRNE)(-)Loci: 4257 4781348-4784063 ~-3K 14933(SLC25A11)(-)Loci: 2971 4841999-4868720 ~-27K 14947(KIF1C)(+)Loci: 2972 5126316-5227430 ~-101K 14961(RABEP1)(+)Loci: 4255 4583578-4589863 ~-6K 14918(CXCL16)(-)Link out to UCSC