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0RAB8A_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameRAB8A
DescriptionRas-related protein rab-8a (oncogene c-mel).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GON/A
Domain Architecture (Details)
InterPro domains assigned to SynO:
Small GTPases are involved in intracellular cell signalling processes. The Ras family includes a large number of small GTPases. Members of the Rab GTPases subfamily have been implicated in vesicle trafficking.The crystal structure of a number of the members of this entry have been determined: .ab GDP-dissociation inhibitor in complex with prenylated YPT1 GTPase . .ec4 ..ab5a .
  IPR003579:Ras small GTPase, Rab type
InterPro domains unassigned to SynO:
Many members of the Ras superfamily of GTPases have been implicated in the regulation of hematopoietic cells.ith roles in growth.urvival.ifferentiation.ytokine production.hemotaxis.esicle-trafficking.nd phagocytosis. The Ras superfamily of proteins now includes over 150 small GTPases (distinguished from the large.eterotrimeric GTPases.he G-proteins). It comprises six subfamilies.he Ras.ho.an.ab.rf.nd Kir/Rem/Rad subfamilies . They exhibit remarkable overall amino acid identities.specially in the regions interacting with the guanine nucleotide exchange factors that catalyze their activation .
  IPR013753:Ras
Many members of the Ras superfamily of GTPases have been implicated in the regulation of hematopoietic cells.ith roles in growth.urvival.ifferentiation.ytokine production.hemotaxis.esicle-trafficking.nd phagocytosis. The Ras superfamily of proteins now includes over 150 small GTPases (distinguished from the large.eterotrimeric GTPases.he G-proteins). It comprises six subfamilies.he Ras.ho.an.ab.rf.nd Kir/Rem/Rad subfamilies . They exhibit remarkable overall amino acid identities.specially in the regions interacting with the guanine nucleotide exchange factors that catalyze their activation .
  IPR001806:Ras GTPase
Proteins with a small GTP-binding domain include Ras.hoA.ab11.ranslation elongation factor G.ranslation initiation factor IF-2.etratcycline resistance protein TetM.DC42.ra.DP-ribosylation factors.dhF.nd many others . In some proteins the domain occurs more than once. Among them there is a large number of small GTP-binding proteins and related domains in larger proteins. Note that the alpha chains of heterotrimeric G proteins are larger proteins in which the NKXD motif is separated from the GxxxxGK[ST] motif (P-loop) by a long insert and are not easily detected by this model.
  IPR005225:Small GTP-binding protein domain
IPR003579:RAB 
Evalue:-110.283996656365 
Location:9-172
SequencesProtein: RAB8A_HUMAN (207 aa)
mRNA: NM_005370
Local Annotation
Synapse Ontology
transport of vesicles in the presynaptic neuron
sdb:0017 Mobilization: synapsins, CAM kinase I  (Evidence:keywords,domains)
?
sdb:0223 transmitter release  (Evidence:keywords,domains)
?
sdb:0328 transmitters release and endocytosis  (Evidence:keywords,domains)
KO assignmentK07901
  Level 3 annotation:
    RAB8A, member Ras oncogene family
  Level 2 annotation:
    GTP-binding proteins
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 116 residues, 16083489-16083835Exon2: 22 residues, 16090035-16090096Exon3: 22 residues, 16093559-16093620Exon4: 28 residues, 16097279-16097357Exon5: 32 residues, 16099246-16099336Exon6: 24 residues, 16099835-16099901Exon7: 19 residues, 16101363-16101414Exon8: 476 residues, 16104021-16105443Exon9: 2 residues, -Jump to RAB8A_HUMAN  
Tune and view alternative isoforms
Loci Cluster (Details)Loci: 4372 14380630-14391171 ~-11K 18171(DDX39)(-)Loci: 3093 14430110-14443670 ~-14K 18178(+)Loci: 4373 14852137-14853264 ~-1K 18201(-)Loci: 4374 14921990-14944730 ~-23K 18203(SLC1A6)(-)Loci: 4375 15325340-15351603 ~-26K 18217(AKAP8)(-)Loci: 4376 15351858-15390833 ~-39K 18218(AKAP8L)(-)Loci: 3094 15699833-15700862 ~-1K 18230(OR10H2)(+)Loci: 4377 15778890-15779847 ~-1K 18231(OR10H1)(-)Loci: 3095 16083489-16105443 ~-22K 18238(RAB8A)(+)Loci: 3096 16169730-16207156 ~-37K 18242(AP1M1)(+)Loci: 4378 16333407-16443762 ~-110K 18245(EPS15L1)(-)Loci: 4371 14119550-14177997 ~-58K 18165(LPHN1)(-)Link out to UCSC