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0RAB6B_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameRAB6B
DescriptionRas-related protein rab-6b.
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005794 Golgi apparatus (NAS)
0003924 GTPase activity (NAS)
0006890 retrograde transport, Golgi to ER (NAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains assigned to SynO:
Small GTPases are involved in intracellular cell signalling processes. The Ras family includes a large number of small GTPases. Members of the Rab GTPases subfamily have been implicated in vesicle trafficking.The crystal structure of a number of the members of this entry have been determined: .ab GDP-dissociation inhibitor in complex with prenylated YPT1 GTPase . .ec4 ..ab5a .
  IPR003579:Ras small GTPase, Rab type
InterPro domains unassigned to SynO:
Many members of the Ras superfamily of GTPases have been implicated in the regulation of hematopoietic cells.ith roles in growth.urvival.ifferentiation.ytokine production.hemotaxis.esicle-trafficking.nd phagocytosis. The Ras superfamily of proteins now includes over 150 small GTPases (distinguished from the large.eterotrimeric GTPases.he G-proteins). It comprises six subfamilies.he Ras.ho.an.ab.rf.nd Kir/Rem/Rad subfamilies . They exhibit remarkable overall amino acid identities.specially in the regions interacting with the guanine nucleotide exchange factors that catalyze their activation .
  IPR013753:Ras
Many members of the Ras superfamily of GTPases have been implicated in the regulation of hematopoietic cells.ith roles in growth.urvival.ifferentiation.ytokine production.hemotaxis.esicle-trafficking.nd phagocytosis. The Ras superfamily of proteins now includes over 150 small GTPases (distinguished from the large.eterotrimeric GTPases.he G-proteins). It comprises six subfamilies.he Ras.ho.an.ab.rf.nd Kir/Rem/Rad subfamilies . They exhibit remarkable overall amino acid identities.specially in the regions interacting with the guanine nucleotide exchange factors that catalyze their activation .
  IPR001806:Ras GTPase
Proteins with a small GTP-binding domain include Ras.hoA.ab11.ranslation elongation factor G.ranslation initiation factor IF-2.etratcycline resistance protein TetM.DC42.ra.DP-ribosylation factors.dhF.nd many others . In some proteins the domain occurs more than once. Among them there is a large number of small GTP-binding proteins and related domains in larger proteins. Note that the alpha chains of heterotrimeric G proteins are larger proteins in which the NKXD motif is separated from the GxxxxGK[ST] motif (P-loop) by a long insert and are not easily detected by this model.
  IPR005225:Small GTP-binding protein domain
IPR013753:Ras 
Evalue:-86.3872146606445 
Location:15-176
SequencesProtein: RAB6B_HUMAN (208 aa)
mRNA: BC002510
Local Annotation
Synapse Ontology
transport of vesicles in the presynaptic neuron
sdb:0017 Mobilization: synapsins, CAM kinase I  (Evidence:domains)
KO assignmentK07894
  Level 3 annotation:
    RAB6B, member Ras oncogene family
  Level 2 annotation:
    GTP-binding proteins
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 111 residues, 135030055-135030386Exon2: 24 residues, 135036108-135036175Exon3: 33 residues, 135039699-135039793Exon4: 39 residues, 135041039-135041151Exon5: 37 residues, 135042818-135042924Exon6: 20 residues, 135043143-135043197Exon7: 21 residues, 135066117-135066176Exon8: 142 residues, 135096930-135097350Exon9: 2 residues, -Jump to RAB6B_HUMAN  
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Loci Cluster (Details)Loci: 4637 135030055-135097350 ~-67K 26534(RAB6B)(-)Loci: 3377 134947924-134980325 ~-32K 26531(TF)(+)Link out to UCSC