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0RAB6A_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameRAB6A
DescriptionRas-related protein rab-6a (rab-6).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0003924 GTPase activity (TAS)
Domain Architecture (Details)
InterPro domains assigned to SynO:
Small GTPases are involved in intracellular cell signalling processes. The Ras family includes a large number of small GTPases. Members of the Rab GTPases subfamily have been implicated in vesicle trafficking.The crystal structure of a number of the members of this entry have been determined: .ab GDP-dissociation inhibitor in complex with prenylated YPT1 GTPase . .ec4 ..ab5a .
  IPR003579:Ras small GTPase, Rab type
InterPro domains unassigned to SynO:
Many members of the Ras superfamily of GTPases have been implicated in the regulation of hematopoietic cells.ith roles in growth.urvival.ifferentiation.ytokine production.hemotaxis.esicle-trafficking.nd phagocytosis. The Ras superfamily of proteins now includes over 150 small GTPases (distinguished from the large.eterotrimeric GTPases.he G-proteins). It comprises six subfamilies.he Ras.ho.an.ab.rf.nd Kir/Rem/Rad subfamilies . They exhibit remarkable overall amino acid identities.specially in the regions interacting with the guanine nucleotide exchange factors that catalyze their activation .
  IPR013753:Ras
Many members of the Ras superfamily of GTPases have been implicated in the regulation of hematopoietic cells.ith roles in growth.urvival.ifferentiation.ytokine production.hemotaxis.esicle-trafficking.nd phagocytosis. The Ras superfamily of proteins now includes over 150 small GTPases (distinguished from the large.eterotrimeric GTPases.he G-proteins). It comprises six subfamilies.he Ras.ho.an.ab.rf.nd Kir/Rem/Rad subfamilies . They exhibit remarkable overall amino acid identities.specially in the regions interacting with the guanine nucleotide exchange factors that catalyze their activation .
  IPR001806:Ras GTPase
Proteins with a small GTP-binding domain include Ras.hoA.ab11.ranslation elongation factor G.ranslation initiation factor IF-2.etratcycline resistance protein TetM.DC42.ra.DP-ribosylation factors.dhF.nd many others . In some proteins the domain occurs more than once. Among them there is a large number of small GTP-binding proteins and related domains in larger proteins. Note that the alpha chains of heterotrimeric G proteins are larger proteins in which the NKXD motif is separated from the GxxxxGK[ST] motif (P-loop) by a long insert and are not easily detected by this model.
  IPR005225:Small GTP-binding protein domain
IPR003579:RAB 
Evalue:-88.2076083105017 
Location:13-176
SequencesProtein: RAB6A_HUMAN (208 aa)
mRNA: NM_198896
Local Annotation
Synapse Ontology
transport of vesicles in the presynaptic neuron
sdb:0017 Mobilization: synapsins, CAM kinase I  (Evidence:domains)
KO assignmentK07893
  Level 3 annotation:
    RAB6A, member Ras oncogene family
  Level 2 annotation:
    GTP-binding proteins
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 773 residues, 73064337-73066655Exon2: 24 residues, 73068346-73068413Exon3: 33 residues, 73096112-73096206Exon4: 39 residues, 73104943-73105055Exon5: 37 residues, 73107305-73107411Exon6: 20 residues, 73109538-73109592Exon7: 21 residues, 73119457-73119516Exon8: 199 residues, 73149258-73149849Exon9: 2 residues, -Jump to RAB6A_HUMAN  
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Loci Cluster (Details)Loci: 3972 73388984-73397778 ~-9K 7384(UCP3)(-)Loci: 3973 73423126-73492291 ~-69K 7386(-)Loci: 3971 73064337-73149849 ~-86K 7373(RAB6A)(-)Link out to UCSC