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0RAB4A_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameRAB4A
DescriptionRas-related protein rab-4a.
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0003924 GTPase activity (TAS)
Domain Architecture (Details)
InterPro domains assigned to SynO:
Small GTPases are involved in intracellular cell signalling processes. The Ras family includes a large number of small GTPases. Members of the Rab GTPases subfamily have been implicated in vesicle trafficking.The crystal structure of a number of the members of this entry have been determined: .ab GDP-dissociation inhibitor in complex with prenylated YPT1 GTPase . .ec4 ..ab5a .
  IPR003579:Ras small GTPase, Rab type
InterPro domains unassigned to SynO:
Many members of the Ras superfamily of GTPases have been implicated in the regulation of hematopoietic cells.ith roles in growth.urvival.ifferentiation.ytokine production.hemotaxis.esicle-trafficking.nd phagocytosis. The Ras superfamily of proteins now includes over 150 small GTPases (distinguished from the large.eterotrimeric GTPases.he G-proteins). It comprises six subfamilies.he Ras.ho.an.ab.rf.nd Kir/Rem/Rad subfamilies . They exhibit remarkable overall amino acid identities.specially in the regions interacting with the guanine nucleotide exchange factors that catalyze their activation .
  IPR013753:Ras
Many members of the Ras superfamily of GTPases have been implicated in the regulation of hematopoietic cells.ith roles in growth.urvival.ifferentiation.ytokine production.hemotaxis.esicle-trafficking.nd phagocytosis. The Ras superfamily of proteins now includes over 150 small GTPases (distinguished from the large.eterotrimeric GTPases.he G-proteins). It comprises six subfamilies.he Ras.ho.an.ab.rf.nd Kir/Rem/Rad subfamilies . They exhibit remarkable overall amino acid identities.specially in the regions interacting with the guanine nucleotide exchange factors that catalyze their activation .
  IPR001806:Ras GTPase
Proteins with a small GTP-binding domain include Ras.hoA.ab11.ranslation elongation factor G.ranslation initiation factor IF-2.etratcycline resistance protein TetM.DC42.ra.DP-ribosylation factors.dhF.nd many others . In some proteins the domain occurs more than once. Among them there is a large number of small GTP-binding proteins and related domains in larger proteins. Note that the alpha chains of heterotrimeric G proteins are larger proteins in which the NKXD motif is separated from the GxxxxGK[ST] motif (P-loop) by a long insert and are not easily detected by this model.
  IPR005225:Small GTP-binding protein domain
IPR003579:RAB 
Evalue:-102.01772876696 
Location:9-172
SequencesProtein: RAB4A_HUMAN (213 aa)
mRNA: BC004309 NM_004578
Local Annotation
Synapse Ontology
transport of vesicles in the presynaptic neuron
sdb:0017 Mobilization: synapsins, CAM kinase I  (Evidence:keywords,domains)
endosome of the presynaptic compartment. A cellular structure that is involved in the transport of proteins in the neuron after the proteins are endocytosed from the outside to the inside of the cell.
sdb:0088 endosome  (Evidence:keywords,domains)
KO assignmentK07879
  Level 3 annotation:
    RAB4A, member Ras oncogene family
  Level 2 annotation:
    GTP-binding proteins
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 80 residues, 227473501-227473740Exon2: 29 residues, 227488855-227488936Exon3: 40 residues, 227491098-227491213Exon4: 23 residues, 227498217-227498280Exon5: 53 residues, 227499851-227500006Exon6: 34 residues, 227501346-227501442Exon7: 44 residues, 227505231-227505359Exon8: 323 residues, 227506175-227507140Exon9: 2 residues, -Jump to RAB4A_HUMANExon1: 80 residues, 227473501-227473740Exon2: 29 residues, 227488855-227488936Exon3: 40 residues, 227491098-227491213Exon4: 23 residues, 227498217-227498280Exon5: 53 residues, 227499851-227500006Exon6: 34 residues, 227501346-227501442Exon7: 44 residues, 227505231-227505359Exon8: 323 residues, 227506175-227507140Exon9: 2 residues, -Jump to RAB4A_HUMAN  
Tune and view alternative isoforms
Loci Cluster (Details)Loci: 3867 227633617-227636466 ~-3K 4109(ACTA1)(-)Loci: 3868 227718952-227761065 ~-42K 4111(ABCB10)(-)Loci: 2595 227473501-227507140 ~-34K 4101(RAB4A)(+)Link out to UCSC