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0RAB3D_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameRAB3D
DescriptionRas-related protein rab-3d.
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0003924 GTPase activity (TAS)
0005515 protein binding (ISS)
0007516 hemocyte development (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains assigned to SynO:
Small GTPases are involved in intracellular cell signalling processes. The Ras family includes a large number of small GTPases. Members of the Rab GTPases subfamily have been implicated in vesicle trafficking.The crystal structure of a number of the members of this entry have been determined: .ab GDP-dissociation inhibitor in complex with prenylated YPT1 GTPase . .ec4 ..ab5a .
  IPR003579:Ras small GTPase, Rab type
InterPro domains unassigned to SynO:
Many members of the Ras superfamily of GTPases have been implicated in the regulation of hematopoietic cells.ith roles in growth.urvival.ifferentiation.ytokine production.hemotaxis.esicle-trafficking.nd phagocytosis. The Ras superfamily of proteins now includes over 150 small GTPases (distinguished from the large.eterotrimeric GTPases.he G-proteins). It comprises six subfamilies.he Ras.ho.an.ab.rf.nd Kir/Rem/Rad subfamilies . They exhibit remarkable overall amino acid identities.specially in the regions interacting with the guanine nucleotide exchange factors that catalyze their activation .
  IPR013753:Ras
Many members of the Ras superfamily of GTPases have been implicated in the regulation of hematopoietic cells.ith roles in growth.urvival.ifferentiation.ytokine production.hemotaxis.esicle-trafficking.nd phagocytosis. The Ras superfamily of proteins now includes over 150 small GTPases (distinguished from the large.eterotrimeric GTPases.he G-proteins). It comprises six subfamilies.he Ras.ho.an.ab.rf.nd Kir/Rem/Rad subfamilies . They exhibit remarkable overall amino acid identities.specially in the regions interacting with the guanine nucleotide exchange factors that catalyze their activation .
  IPR001806:Ras GTPase
Proteins with a small GTP-binding domain include Ras.hoA.ab11.ranslation elongation factor G.ranslation initiation factor IF-2.etratcycline resistance protein TetM.DC42.ra.DP-ribosylation factors.dhF.nd many others . In some proteins the domain occurs more than once. Among them there is a large number of small GTP-binding proteins and related domains in larger proteins. Note that the alpha chains of heterotrimeric G proteins are larger proteins in which the NKXD motif is separated from the GxxxxGK[ST] motif (P-loop) by a long insert and are not easily detected by this model.
  IPR005225:Small GTP-binding protein domain
IPR003579:RAB 
Evalue:-95.397940008672 
Location:23-186
SequencesProtein: RAB3D_HUMAN (219 aa)
mRNA: NM_004283
Local Annotation
Synapse Ontology
transport of vesicles in the presynaptic neuron
sdb:0017 Mobilization: synapsins, CAM kinase I  (Evidence:keywords,domains)
Calcium release from RyR (Ryanodine Receptor) in the SR (Sarcoplasmic Reticulum) is activated by the calcium induced-calcium-release
sdb:0325 RyR-CICR  (Evidence:keywords,domains)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 390 residues, 11296093-11297261Exon2: 43 residues, 11307122-11307247Exon3: 41 residues, 11307340-11307459Exon4: 98 residues, 11308847-11309136Exon5: 61 residues, 11311144-11311321Exon6: 2 residues, -Jump to RAB3D_HUMAN  
Tune and view alternative isoforms
Loci Cluster (Details)Loci: 4364 10305453-10311300 ~-6K 17970(ICAM3)(-)Loci: 4365 10544347-10558991 ~-15K 17988(AP1M2)(-)Loci: 3088 10689754-10803579 ~-114K 18002(DNM2)(+)Loci: 3089 10843252-10894447 ~-51K 18009(CARM1)(+)Loci: 3090 11061131-11105490 ~-44K 18013(LDLR)(+)Loci: 4366 11296093-11311321 ~-15K 18027(RAB3D)(-)Loci: 4363 9825394-9908070 ~-83K 17941(OLFM2)(-)Link out to UCSC