SynDB Home Page
SynDB Home Page
Browse
Search
Download
Help
People
links

blue bulletSynDB protein details  


Parse error: syntax error, unexpected T_VARIABLE in /home/kongl/syndb/www/sdb_nats.php on line 52
0RAB34_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameRAB34
DescriptionRas-related protein rab-34 (rab-39) (ras-related protein rah).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GON/A
Domain Architecture (Details)
InterPro domains assigned to SynO:
Small GTPases are involved in intracellular cell signalling processes. The Ras family includes a large number of small GTPases. Members of the Rab GTPases subfamily have been implicated in vesicle trafficking.The crystal structure of a number of the members of this entry have been determined: .ab GDP-dissociation inhibitor in complex with prenylated YPT1 GTPase . .ec4 ..ab5a .
  IPR003579:Ras small GTPase, Rab type
InterPro domains unassigned to SynO:
Many members of the Ras superfamily of GTPases have been implicated in the regulation of hematopoietic cells.ith roles in growth.urvival.ifferentiation.ytokine production.hemotaxis.esicle-trafficking.nd phagocytosis. The Ras superfamily of proteins now includes over 150 small GTPases (distinguished from the large.eterotrimeric GTPases.he G-proteins). It comprises six subfamilies.he Ras.ho.an.ab.rf.nd Kir/Rem/Rad subfamilies . They exhibit remarkable overall amino acid identities.specially in the regions interacting with the guanine nucleotide exchange factors that catalyze their activation .
  IPR013753:Ras
Many members of the Ras superfamily of GTPases have been implicated in the regulation of hematopoietic cells.ith roles in growth.urvival.ifferentiation.ytokine production.hemotaxis.esicle-trafficking.nd phagocytosis. The Ras superfamily of proteins now includes over 150 small GTPases (distinguished from the large.eterotrimeric GTPases.he G-proteins). It comprises six subfamilies.he Ras.ho.an.ab.rf.nd Kir/Rem/Rad subfamilies . They exhibit remarkable overall amino acid identities.specially in the regions interacting with the guanine nucleotide exchange factors that catalyze their activation .
  IPR001806:Ras GTPase
Proteins with a small GTP-binding domain include Ras.hoA.ab11.ranslation elongation factor G.ranslation initiation factor IF-2.etratcycline resistance protein TetM.DC42.ra.DP-ribosylation factors.dhF.nd many others . In some proteins the domain occurs more than once. Among them there is a large number of small GTP-binding proteins and related domains in larger proteins. Note that the alpha chains of heterotrimeric G proteins are larger proteins in which the NKXD motif is separated from the GxxxxGK[ST] motif (P-loop) by a long insert and are not easily detected by this model.
  IPR005225:Small GTP-binding protein domain
IPR003579:RAB 
Evalue:-49.2924298239021 
Location:54-219
SequencesProtein: RAB34_HUMAN (259 aa)
mRNA: CR622817 NM_031934
Local Annotation
Synapse Ontology
transport of vesicles in the presynaptic neuron
sdb:0017 Mobilization: synapsins, CAM kinase I  (Evidence:domains)
KO assignmentK07921
  Level 3 annotation:
    RAB34, member Ras oncogene family
  Level 2 annotation:
    GTP-binding proteins
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 143 residues, 24065429-24065855Exon2: 38 residues, 24065937-24066045Exon3: 32 residues, 24066176-24066267Exon4: 29 residues, 24066339-24066421Exon5: 19 residues, 24066600-24066652Exon6: 23 residues, 24066785-24066850Exon7: 36 residues, 24066944-24067046Exon8: 24 residues, 24067137-24067203Exon9: 32 residues, 24068047-24068139Exon10: 220 residues, 24068357-24069013Exon11: 2 residues, -Jump to RAB34_HUMANExon1: 138 residues, 24065442-24065855Exon2: 38 residues, 24065937-24066045Exon3: 32 residues, 24066176-24066267Exon4: 29 residues, 24066339-24066421Exon5: 19 residues, 24066600-24066652Exon6: 23 residues, 24066785-24066850Exon7: 36 residues, 24066944-24067046Exon8: 25 residues, 24067137-24067206Exon9: 32 residues, 24068047-24068139Exon10: 215 residues, 24068357-24068996Exon11: 2 residues, -Jump to RAB34_HUMAN  
Tune and view alternative isoforms
Loci Cluster (Details)Loci: 4275 23928711-23950183 ~-21K 15382(SPAG5)(-)Loci: 4276 23999734-24013060 ~-13K 15388(SDF2)(-)Loci: 4277 24065429-24069013 ~-4K 15393(RAB34)(-)Loci: 4274 23897851-23903770 ~-6K 15376(UNC119)(-)Link out to UCSC