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0RAB2B_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameRAB2B
DescriptionRas-related protein rab-2b.
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GON/A
Domain Architecture (Details)
InterPro domains assigned to SynO:
Small GTPases are involved in intracellular cell signalling processes. The Ras family includes a large number of small GTPases. Members of the Rab GTPases subfamily have been implicated in vesicle trafficking.The crystal structure of a number of the members of this entry have been determined: .ab GDP-dissociation inhibitor in complex with prenylated YPT1 GTPase . .ec4 ..ab5a .
  IPR003579:Ras small GTPase, Rab type
InterPro domains unassigned to SynO:
Many members of the Ras superfamily of GTPases have been implicated in the regulation of hematopoietic cells.ith roles in growth.urvival.ifferentiation.ytokine production.hemotaxis.esicle-trafficking.nd phagocytosis. The Ras superfamily of proteins now includes over 150 small GTPases (distinguished from the large.eterotrimeric GTPases.he G-proteins). It comprises six subfamilies.he Ras.ho.an.ab.rf.nd Kir/Rem/Rad subfamilies . They exhibit remarkable overall amino acid identities.specially in the regions interacting with the guanine nucleotide exchange factors that catalyze their activation .
  IPR013753:Ras
Many members of the Ras superfamily of GTPases have been implicated in the regulation of hematopoietic cells.ith roles in growth.urvival.ifferentiation.ytokine production.hemotaxis.esicle-trafficking.nd phagocytosis. The Ras superfamily of proteins now includes over 150 small GTPases (distinguished from the large.eterotrimeric GTPases.he G-proteins). It comprises six subfamilies.he Ras.ho.an.ab.rf.nd Kir/Rem/Rad subfamilies . They exhibit remarkable overall amino acid identities.specially in the regions interacting with the guanine nucleotide exchange factors that catalyze their activation .
  IPR001806:Ras GTPase
Proteins with a small GTP-binding domain include Ras.hoA.ab11.ranslation elongation factor G.ranslation initiation factor IF-2.etratcycline resistance protein TetM.DC42.ra.DP-ribosylation factors.dhF.nd many others . In some proteins the domain occurs more than once. Among them there is a large number of small GTP-binding proteins and related domains in larger proteins. Note that the alpha chains of heterotrimeric G proteins are larger proteins in which the NKXD motif is separated from the GxxxxGK[ST] motif (P-loop) by a long insert and are not easily detected by this model.
  IPR005225:Small GTP-binding protein domain
IPR003579:RAB 
Evalue:-107.958607314842 
Location:7-170
SequencesProtein: RAB2B_HUMAN (216 aa)
mRNA: NM_032846
Local Annotation
Synapse Ontology
transport of vesicles in the presynaptic neuron
sdb:0017 Mobilization: synapsins, CAM kinase I  (Evidence:domains)
KO assignmentK07878
  Level 3 annotation:
    RAB2B, member Ras oncogene family
  Level 2 annotation:
    GTP-binding proteins
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 440 residues, 20997027-20998345Exon2: 119 residues, 20998950-20999302Exon3: 25 residues, 21000348-21000417Exon4: 39 residues, 21001654-21001766Exon5: 33 residues, 21006355-21006448Exon6: 29 residues, 21006668-21006751Exon7: 24 residues, 21012865-21012933Exon8: 26 residues, 21014526-21014598Exon9: 47 residues, 21014825-21014961Exon10: 2 residues, -Jump to RAB2B_HUMAN  
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Loci Cluster (Details)Loci: 4114 20997027-21014961 ~-18K 10801(RAB2B)(-)Loci: 4113 20628075-20636639 ~-9K 10786(ZNF219)(-)Link out to UCSC