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0RAB24_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameRAB24
DescriptionRas-related protein rab-24.
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GON/A
Domain Architecture (Details)
InterPro domains assigned to SynO:
Small GTPases are involved in intracellular cell signalling processes. The Ras family includes a large number of small GTPases. Members of the Rab GTPases subfamily have been implicated in vesicle trafficking.The crystal structure of a number of the members of this entry have been determined: .ab GDP-dissociation inhibitor in complex with prenylated YPT1 GTPase . .ec4 ..ab5a .
  IPR003579:Ras small GTPase, Rab type
InterPro domains unassigned to SynO:
Many members of the Ras superfamily of GTPases have been implicated in the regulation of hematopoietic cells.ith roles in growth.urvival.ifferentiation.ytokine production.hemotaxis.esicle-trafficking.nd phagocytosis. The Ras superfamily of proteins now includes over 150 small GTPases (distinguished from the large.eterotrimeric GTPases.he G-proteins). It comprises six subfamilies.he Ras.ho.an.ab.rf.nd Kir/Rem/Rad subfamilies . They exhibit remarkable overall amino acid identities.specially in the regions interacting with the guanine nucleotide exchange factors that catalyze their activation .
  IPR013753:Ras
Many members of the Ras superfamily of GTPases have been implicated in the regulation of hematopoietic cells.ith roles in growth.urvival.ifferentiation.ytokine production.hemotaxis.esicle-trafficking.nd phagocytosis. The Ras superfamily of proteins now includes over 150 small GTPases (distinguished from the large.eterotrimeric GTPases.he G-proteins). It comprises six subfamilies.he Ras.ho.an.ab.rf.nd Kir/Rem/Rad subfamilies . They exhibit remarkable overall amino acid identities.specially in the regions interacting with the guanine nucleotide exchange factors that catalyze their activation .
  IPR001806:Ras GTPase
Proteins with a small GTP-binding domain include Ras.hoA.ab11.ranslation elongation factor G.ranslation initiation factor IF-2.etratcycline resistance protein TetM.DC42.ra.DP-ribosylation factors.dhF.nd many others . In some proteins the domain occurs more than once. Among them there is a large number of small GTP-binding proteins and related domains in larger proteins. Note that the alpha chains of heterotrimeric G proteins are larger proteins in which the NKXD motif is separated from the GxxxxGK[ST] motif (P-loop) by a long insert and are not easily detected by this model.
  IPR005225:Small GTP-binding protein domain
IPR013753:Ras 
Evalue:-47.7447280883789 
Location:9-174
SequencesProtein: RAB24_HUMAN (203 aa)
mRNA: AF258583 NM_001031677
Local Annotation
Synapse Ontology
transport of vesicles in the presynaptic neuron
sdb:0017 Mobilization: synapsins, CAM kinase I  (Evidence:domains)
KO assignmentK07912
  Level 3 annotation:
    RAB24, member Ras oncogene family
  Level 2 annotation:
    GTP-binding proteins
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 201 residues, 176660813-176661414Exon2: 23 residues, 176661531-176661594Exon3: 19 residues, 176661734-176661785Exon4: 35 residues, 176662003-176662103Exon5: 24 residues, 176662183-176662251Exon6: 28 residues, 176662358-176662437Exon7: 25 residues, 176662615-176662684Exon8: 179 residues, 176662778-176663311Exon9: 2 residues, -Jump to RAB24_HUMANExon1: 119 residues, 176661060-176661414Exon2: 23 residues, 176661531-176661594Exon3: 125 residues, 176661734-176662103Exon4: 24 residues, 176662183-176662251Exon5: 28 residues, 176662358-176662437Exon6: 25 residues, 176662615-176662684Exon7: 107 residues, 176662778-176663095Exon8: 2 residues, -Jump to RAB24_HUMAN  
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Loci Cluster (Details)Loci: 4757 176660813-176663311 ~-2K 30017(RAB24)(-)Loci: 4758 176816219-176833271 ~-17K 30039(DBN1)(-)Loci: 3512 176493531-176655367 ~-162K 30012(NSD1)(+)Link out to UCSC