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0RAB18_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameRAB18
DescriptionRas-related protein rab-18.
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0003924 GTPase activity (NAS)
0006897 endocytosis (NAS)
0007264 small GTPase mediated signal transduction (NAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains assigned to SynO:
Small GTPases are involved in intracellular cell signalling processes. The Ras family includes a large number of small GTPases. Members of the Rab GTPases subfamily have been implicated in vesicle trafficking.The crystal structure of a number of the members of this entry have been determined: .ab GDP-dissociation inhibitor in complex with prenylated YPT1 GTPase . .ec4 ..ab5a .
  IPR003579:Ras small GTPase, Rab type
InterPro domains unassigned to SynO:
Many members of the Ras superfamily of GTPases have been implicated in the regulation of hematopoietic cells.ith roles in growth.urvival.ifferentiation.ytokine production.hemotaxis.esicle-trafficking.nd phagocytosis. The Ras superfamily of proteins now includes over 150 small GTPases (distinguished from the large.eterotrimeric GTPases.he G-proteins). It comprises six subfamilies.he Ras.ho.an.ab.rf.nd Kir/Rem/Rad subfamilies . They exhibit remarkable overall amino acid identities.specially in the regions interacting with the guanine nucleotide exchange factors that catalyze their activation .
  IPR013753:Ras
Many members of the Ras superfamily of GTPases have been implicated in the regulation of hematopoietic cells.ith roles in growth.urvival.ifferentiation.ytokine production.hemotaxis.esicle-trafficking.nd phagocytosis. The Ras superfamily of proteins now includes over 150 small GTPases (distinguished from the large.eterotrimeric GTPases.he G-proteins). It comprises six subfamilies.he Ras.ho.an.ab.rf.nd Kir/Rem/Rad subfamilies . They exhibit remarkable overall amino acid identities.specially in the regions interacting with the guanine nucleotide exchange factors that catalyze their activation .
  IPR001806:Ras GTPase
Proteins with a small GTP-binding domain include Ras.hoA.ab11.ranslation elongation factor G.ranslation initiation factor IF-2.etratcycline resistance protein TetM.DC42.ra.DP-ribosylation factors.dhF.nd many others . In some proteins the domain occurs more than once. Among them there is a large number of small GTP-binding proteins and related domains in larger proteins. Note that the alpha chains of heterotrimeric G proteins are larger proteins in which the NKXD motif is separated from the GxxxxGK[ST] motif (P-loop) by a long insert and are not easily detected by this model.
  IPR005225:Small GTP-binding protein domain
IPR003579:RAB 
Evalue:-103.744727494897 
Location:9-172
SequencesProtein: RAB18_HUMAN (206 aa)
mRNA: AY574034 NM_021252
Local Annotation
Synapse Ontology
transport of vesicles in the presynaptic neuron
sdb:0017 Mobilization: synapsins, CAM kinase I  (Evidence:keywords,domains)
endosome of the presynaptic compartment. A cellular structure that is involved in the transport of proteins in the neuron after the proteins are endocytosed from the outside to the inside of the cell.
sdb:0088 endosome  (Evidence:keywords,domains)
KO assignmentK07910
  Level 3 annotation:
    RAB18, member Ras oncogene family
  Level 2 annotation:
    GTP-binding proteins
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 51 residues, 27833220-27833372Exon2: 20 residues, 27838809-27838865Exon3: 22 residues, 27855762-27855824Exon4: 31 residues, 27860463-27860550Exon5: 26 residues, 27861441-27861514Exon6: 41 residues, 27862669-27862788Exon7: 24 residues, 27862862-27862929Exon8: 653 residues, 27866810-27868764Exon9: 2 residues, -Jump to RAB18_HUMANExon1: 40 residues, 27833254-27833372Exon2: 20 residues, 27838809-27838865Exon3: 22 residues, 27855762-27855824Exon4: 26 residues, 27861441-27861514Exon5: 41 residues, 27862669-27862788Exon6: 24 residues, 27862862-27862929Exon7: 766 residues, 27866810-27869103Exon8: 2 residues, -Jump to RAB18_HUMAN  
Tune and view alternative isoforms
Loci Cluster (Details)Loci: 3882 27439390-27483327 ~-44K 4619(YME1L1)(-)Loci: 2608 27484297-27515854 ~-32K 4624(MASTL)(+)Loci: 2609 27833220-27869103 ~-36K 4631(RAB18)(+)Loci: 3881 27075532-27189965 ~-114K 4610(ABI1)(-)Link out to UCSC