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1Q9UEB1_HUMAN*   Trembl (?) | Description Local Annotation Link Reference
General Information
DescriptionBc85395_4 (fragment).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0016021 integral to membrane (IEA)
0004984 olfactory receptor activity (IEA)
0004872 receptor activity (IEA)
0007186 G-protein coupled receptor protein signalin... (IEA)
0007165 signal transduction (IEA)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
G-protein-coupled receptors.PCRs.onstitute a vast protein family that encompasses a wide range of functions (including various autocrine.aracrine and endocrine processes). They show considerable diversity at the sequence level.n the basis of which they can be separated into distinct groups. We use the term clan to describe the GPCRs.s they embrace a group of families for which there are indications of evolutionary relationship.ut between which there is no statistically significant similarity in sequence . The currently known clan members include the rhodopsin-like GPCRs.he secretin-like GPCRs.he cAMP receptors.he fungal mating pheromone receptors.nd the metabotropic glutamate receptor family. There is a specialized database for GPCRs: The rhodopsin-like GPCRs themselves represent a widespread protein family that includes hormone.eurotransmitter and light receptors.ll of which transduce extracellular signals through interaction with guanine nucleotide-binding (G) proteins. Although their activating ligands vary widely in structure and character.he amino acid sequences of the receptors are very similar and are believed to adopt a common structural framework comprising 7transmembrane (TM) helices .
  IPR000276:Rhodopsin-like GPCR superfamily
The olfactory system is a highly-specialised chemical recognition systemthat.ike the immune system.s capable of discriminating with tremendoussensitivity between numerous foreign molecules in the environment.Olfactory transduction is believed to be initiated by the binding ofodorants to specific receptor proteins in the cilia of olfactory receptorcells. Although little is known about the precise mechanism by whichodorant binding might initiate membrane depolarisation.t is believedthat cyclic AMP may serve as an intracellular messenger for olfactorytransduction .The olfactory receptors are integral membrane proteins that belong to asuperfamily of G-protein-coupled receptors. The activating ligands of thedifferent superfamily members vary widely in structure and character.etthe proteins appear faithfully to have conserved a basic structural framework.elieved to consist of 7 transmembrane (TM) helices. Although thesequences of these proteins are very diverse.eflecting to some extentthis broad range of activating ligands.evertheless.otifs have beenidentified in the TM regions that are characteristic of virtually theentire superfamily . Amongst the exceptions are the olfactoryreceptors.hich cluster together in a subfamily that lacks significantmatches with domains 2. and 6 .
  IPR000725:Olfactory receptor
This domain is found as the core structure in Lsm (like-Sm) proteins and bacterial Lsm-related Hfq proteins.nd as the middle domain of the mechanosensitive channel protein MscS. In each case.he domain adopts a core structure consisting of an open beta-barrel with an SH3-like topology.Lsm proteins have diverse functions.nd are thought to be important modulators of RNA biogenesis and function . The Sm proteins form part of specific small nuclear ribonucleoproteins (snRNPs) that are involved in the processing of pre-mRNAs to mature mRNAs.nd are a major component of the eukaryotic spliceosome. These snRNPs consist of seven Sm proteins (B/B.1.2.3.. and G).lus a small nuclear RNA (snRNA) (either U1.2.5 or U4/6) . Other snRNPs.uch as U7 contain different Lsm proteins. Lsm proteins are also found in archaebacteria.hich do not have any splicing apparatus suggesting a more general role for Lsm proteins.The pleiotropic translational regulator Hfq (host factor Q) is a bacterial Lsm-like protein.hich modulates the structure of numerous RNA molecules by binding preferentially to A/U-rich sequences in RNA . Hfq forms an Lsm-like fold.owever.nlike the heptameric Sm proteins.fq forms a homo-hexameric ring.The middle domain of the mechanosensitive channel of small conductance protein (MscS or YggB) structurally resembles an Lsm protein. MscS is a mechanosensitive channel present in the membrane of bacteria.rchaea and eukarya that responds both to stretching of the cell membrane and to membrane depolarisation . MscS folds as a homo-heptamer with a cylindrical shape.nd can be divided into transmembrane and extramembrane regions: an N-terminal periplasmic region. transmembrane region.nd a C-terminal cytoplasmic region. The C-terminal cytoplasmic region can be further divided into middle and C-terminal domains.hich together create a framework that connects to the cytoplasm through distinct openings. The middle domain exhibits an Lsm-like structure.onsisting of five beta-strands that pack together with those of other subunits to form a barrel-like sheet extending around the entire protein.
  IPR010920:Like-Sm ribonucleoprotein-related, core
SequencesProtein: Q9UEB1_HUMAN (148 aa)
mRNA: BC101587
Local Annotation
Synapse Ontology
Calcium release from RyR (Ryanodine Receptor) in the SR (Sarcoplasmic Reticulum) is activated by the calcium induced-calcium-release
sdb:0325 RyR-CICR  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 376 residues, 14852137-14853264Exon2: 2 residues, -Jump to Q9UEB1_HUMAN  
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Loci Cluster (Details)Loci: 4372 14380630-14391171 ~-11K 18171(DDX39)(-)Loci: 3093 14430110-14443670 ~-14K 18178(+)Loci: 4373 14852137-14853264 ~-1K 18201(-)Loci: 4374 14921990-14944730 ~-23K 18203(SLC1A6)(-)Loci: 4375 15325340-15351603 ~-26K 18217(AKAP8)(-)Loci: 4376 15351858-15390833 ~-39K 18218(AKAP8L)(-)Loci: 3094 15699833-15700862 ~-1K 18230(OR10H2)(+)Loci: 4377 15778890-15779847 ~-1K 18231(OR10H1)(-)Loci: 3095 16083489-16105443 ~-22K 18238(RAB8A)(+)Loci: 3096 16169730-16207156 ~-37K 18242(AP1M1)(+)Loci: 4378 16333407-16443762 ~-110K 18245(EPS15L1)(-)Loci: 4371 14119550-14177997 ~-58K 18165(LPHN1)(-)Link out to UCSC