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1Q9HBM1_HUMAN*   Trembl (?) | Description Local Annotation Link Reference
General Information
DescriptionHypothetical protein ad024 (kinetochore protein spc25).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
Domain Architecture (Details)
InterPro domains assigned to SynO:
Soluble N-ethylmaleimide attachment protein receptor (SNARE) proteins are a family of membrane-associated proteins characterised by an alpha-helical coiled-coil domain called the SNARE motif . These proteins are classified as v-SNAREs and t-SNAREs based on their localisation on vesicle or target membrane; another classification scheme defines R-SNAREs and Q-SNAREs.s based on the conserved arginine or glutamine residue in the centre of the SNARE motif. SNAREs are localised to distinct membrane compartments of the secretory and endocytic trafficking pathways.nd contribute to the specificity of intracellular membrane fusion processes.The t-SNARE domain consists of a 4-helical bundle with a coiled-coil twist. The SNARE motif contributes to the fusion of two membranes. SNARE motifs fall into four classes: homologues of syntaxin 1a (t-SNARE).AMP-2 (v-SNARE).nd the N- and C-terminal SNARE motifs of SNAP-25. It is thought that one member from each class interacts to form a SNARE complex.The SNARE motif represented in this entry is found in the N-terminal domains of certain syntaxin family members: syntaxin 1a.hich is required for neurotransmitter release.yntaxin 6.hich is found in endosomal transport vesicles .east Sso1p .nd Vam3p. yeast syntaxin essential for vacuolar fusion . The SNARE motifs in these proteins share structural similarity.espite having a low level of sequence similarity.
InterPro domains unassigned to SynO:
Spc25 is a conserved eukaryotic kinetochore protein involved in cell division. In fungi the Spc25 protein is a subunit of the Nuf2-Ndc80 complex .nd in vertebrates it forms part of the Ndc80 complex . It is required for chromosome segregation.
  IPR013255:Kinetochore-Ndc80 subunit Spc25
SequencesProtein: Q9HBM1_HUMAN (224 aa)
mRNA: NM_020675
Local Annotation
Synapse Ontology
Fusion of intracellular membrane-bound vesicles with the pre-synaptic membrane of the neuronal cell resulting in release of neurotransmitter into the synaptic cleft.
sdb:0049 synaptic vesicle fusion  (Evidence:domains)
priming for exocytosis prepares the calcium-dependent release and may involve partial fusion process. The vesicles are primed and become responsive to calcium.
sdb:0120 priming  (Evidence:domains)
attachment of the vesicle filled with transmitters involves a specific interaction between the vesicle membrane and the presynaptic active zone.
sdb:0148 docking  (Evidence:domains)
sdb:0328 transmitters release and endocytosis  (Evidence:domains)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 222 residues, 169435647-169436311Exon2: 35 residues, 169438340-169438439Exon3: 37 residues, 169440827-169440932Exon4: 51 residues, 169441993-169442140Exon5: 24 residues, 169453981-169454047Exon6: 51 residues, 169454142-169454289Exon7: 41 residues, 169455073-169455190Exon8: 2 residues, -Jump to Q9HBM1_HUMAN  
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Loci Cluster (Details)Loci: 4477 169693106-169927259 ~-234K 21526(LRP2)(-)Loci: 4476 169435647-169455190 ~-20K 21519(-)Link out to UCSC