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1Q9H8Z6_HUMAN*   Trembl (?) | Description Local Annotation Link Reference
General Information
NameN/A
DescriptionHypothetical protein flj13119.
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005525 GTP binding (IEA)
0003746 translation elongation factor activity (IEA)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
This domain is found in elongation factor G.longation factor 2 and some tetracycline resistance proteins and adopts a ribosomal protein S5 domain 2-like fold.
  IPR005517:Elongation factor G, domain IV
This domain includes the C-terminal regions of the elongation factors EF-G and eEF-2.nd of some tetracycline resistance proteins. This domain adopts a ferredoxin-like fold consisting of an alpha/beta sandwich with anti-parallel beta-sheets. It is often found associated with .hich contains the signatures for the N-terminus of the proteins. This domain resembles the topology of domain III found in the elongation factors EF-G and eEF-2.ith which it forms the C-terminal block.lthough they are not superimposable and domain III lacks some of the characteristics of this domain. EF-G participates in the elongation phase of protein synthesis.nd also facilitates the release of tRNA and mRNA from the ribosome .
  IPR000640:Elongation factor G, C-terminal
A beta barrel of circularly permuted topology is found in many transcription proteins.ncluding initiation and elongation factors.nd also some ribosomal proteins.lthough in these cases the fold is elaborated with additional structures. The beta barrel domain is represented by domain 2 of the elongation factors EF-Tu and eEF1A .oth of which function to recognize and transport aminoacyl-tRNA to the acceptor (A) site of the ribosome during the elongation process.nd of EF-G .hich functions in translocating the peptidyl tRNA from the A site to the peptidyl (P) site. This domain is also present in initiation factors.n domain 2 of eIF2 gamma subunit .nd domains 2 and 4 of IF2/eIF5B .oth of which function to transport the initiator methionyl-tRNA to the ribosome. This beta barrel domain may be involved in interactions with the switch 2 region to stabilise the relative orientations of the domains.hich undergo functionally important conformational changes between GTP- and GDP-bound states.The SSF signature in this entry is currently under review. Please be aware that some of the protein hits may be false positives.
  IPR009000:Translation factor
Elongation factor G (EF-G) participates in the elongation phase of protein synthesis by promoting the GTP-dependent translocation of the peptidyl tRNA of the nascent protein chain from the A-site (acceptor site) to the P-site (peptidyl tRNA site) of the ribosome. EF-G also has a role after the termination phase of translation.here.ogether with the ribosomal recycling factor.t facilitates the release of tRNA and mRNA from the ribosome.nd the splitting of the ribosome into two subunits . EF-G is folded into five domains.ith domains I and II forming the N-terminal block.omains IV and V forming the C-terminal block.nd domain III providing the covalently-linked flexible connection between the two. Domains III and V have the same fold (although they are not completely superimposable and domain III lacks some of the superfamily characteristics).onsisting of an alpha/beta sandwich with an antiparallel beta-sheet in a (beta/alpha/beta)x2 topology . This double split beta/alpha/beta fold is also seen in a number of ribonucleotide binding proteins. It is the most common motif occurring in the translation system and is referred to as the ribonucleoprotein (RNP) or RNA recognition (RRM) motif. This domain is found in several elongation factors.ncluding EF-G and eEF-2.s well as in some tetracycline resistance proteins.eptide chain release factors .nd in the C-terminal region of the bacterial hypothetical protein.igZ.
  IPR009022:Elongation factor G, III and V
IPR000640:EFG_C 
Evalue:-16.6382713317871 
Location:716-804IPR005517:EFG_IV 
Evalue:-3.22914791107178 
Location:604-631IPR009000:Translat_factor 
Evalue:0 
Location:235-347IPR009022:EFG_III_V 
Evalue:0 
Location:349-426IPR009000:Translat_factor 
Evalue:0 
Location:142-155IPR009000:Translat_factor 
Evalue:0 
Location:92-103
SequencesProtein: Q9H8Z6_HUMAN (857 aa)
mRNA: BC014628
Local Annotation
Synapse Ontology
Calcium release from RyR (Ryanodine Receptor) in the SR (Sarcoplasmic Reticulum) is activated by the calcium induced-calcium-release
sdb:0325 RyR-CICR  (Evidence:keywords)
KO assignmentK03234
  Level 3 annotation:
    elongation factor EF-2
  Level 2 annotation:
    Translation factors
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 111 residues, 80209627-80209957Exon2: 63 residues, 80218053-80218238Exon3: 321 residues, 80230860-80231819Exon4: 51 residues, 80237108-80237256Exon5: 46 residues, 80243248-80243380Exon6: 48 residues, 80294112-80294251Exon7: 57 residues, 80299047-80299214Exon8: 52 residues, 80299473-80299625Exon9: 35 residues, 80304560-80304660Exon10: 43 residues, 80306845-80306968Exon11: 47 residues, 80307586-80307723Exon12: 27 residues, 80308429-80308506Exon13: 43 residues, 80310243-80310367Exon14: 73 residues, 80317702-80317917Exon15: 48 residues, 80319813-80319951Exon16: 46 residues, 80320665-80320799Exon17: 30 residues, 80332086-80332171Exon18: 24 residues, 80338483-80338551Exon19: 38 residues, 80341083-80341193Exon20: 14 residues, 80342009-80342046Exon21: 2 residues, -Jump to Q9H8Z6_HUMAN  
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