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1Q9BZV8_HUMAN*   Trembl (?) | Description Local Annotation Link Reference
General Information
DescriptionPou 5 domain protein.
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005634 nucleus (IEA)
0003700 transcription factor activity (IEA)
0006355 regulation of transcription, DNA-dependent (IEA)

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Domain Architecture (Details)
InterPro domains assigned to SynO:
POU proteins are eukaryotic transcription factors containing a bipartite DNA binding domain referred to as the POU domain. The acronym POU (pronounced pow) is derived from the names of three mammalian transcription factors.he pituitary-specific Pit-1.he octamer-binding proteins Oct-1 and Oct-2.nd the neural Unc-86 from Caenorhabditis elegans. POU domain genes have been described in organisms as divergent as Caenorhabditis elegans.rosophila.enopus.ebrafish and human but have not been yet identified in plants and fungi. The various members of the POU family have a wide variety of functions.ll of which are related to the function of the neuroendocrine system and the development of an organism . Some other genes are also regulated.ncluding those for immunoglobulin light and heavy chains (Oct-2) and trophic hormone genes.uch as those for prolactin and growth hormone (Pit-1). The POU domain is a bipartite domain composed of two subunits separated by a non-conserved region of 15-55 aa. The N-terminal subunit is known as the POU-specific (POUs) domain ().hile the C-terminal subunit is a homeobox domain (). 3D structures of complexes including both POU subdomains bound to DNA are available. Both subdomains contain the structural motif helix-turn-helix.hich directly associates with the two components of bipartite DNA binding sites.nd both are required for high affinity sequence-specific DNA-binding. The domain may also be involved in protein-protein interactions . The subdomains are connected by a flexible linker . In proteins a POU-specific domain is always accompanied by a homeodomain. Despite of the lack of sequence homology.D structure of POUs is similar to 3D structure of bacteriophage lambda repressor and other members of HTH_3 family .This entry represents the POU-specific subunit of the POU domain.
InterPro domains unassigned to SynO:
Bacteriophage lambda C1 repressor controls the expression of viral genes as part of the lysogeny/lytic growth switch. C1 is essential for maintaining the phage replicates non-disruptively along with the host. If the host cell is threatened.hen lytic growth is induced. The Lambda C1 repressor consists of two domains connected by a linker: an N-terminal DNA-binding domain that also mediates interactions with RNA polymerase.nd a C-terminal dimerisation domain . The DNA-binding domain consists of four helices in a closed folded leaf motif. Several different phage repressors from different helix-turn-helix families contain DNA-binding domains that adopt a similar topology. These include the Lambda Cro repressor.acteriophage 434 C1 and Cro repressors.22 C2 repressor.nd bacteriophage Mu Ner protein.The DNA-binding domain of Bacillus subtilis spore inhibition repressor SinR is identical to that of phage repressors . SinR represses sporulation.hich only occurs in response to adverse conditions. This provides a possible evolutionary link between the two adaptive responses of bacterial sporulation and prophage induction.Other DNA-binding domains also display similar structural folds to that of Lambda C1. These include bacterial regulators such as the purine repressor (PurR).he lactose repressor (Lacr) and the fructose repressor (FruR).ach of which has an N-terminal DNA-binding domain that exhibits a fold similar to that of lambda C1.xcept that they lack the first helix . POU-specific domains found in transcription factors such as in and Hepatocyte nuclear factor 1a (LFB1/HNF1) display four-helical fold DNA-binding domains similar to that of Lambda C1 . The N-terminal domain of cyanase has an alpha-helix bundle motif similar to Lambda C1.ut it probably does not bind DNA. Cyanase is an enzyme found in bacteria and plants that catalyses the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide in response to extracellular cyanate .The SSF signature in this entry is currently under review. Please be aware that some of the protein hits may be false positives.
  IPR010982:Lambda repressor-like, DNA-binding
SequencesProtein: Q9BZV8_HUMAN (186 aa)
mRNA: AF268617
Local Annotation
Synapse Ontology
The formation of a synapse.
sdb:0034 synaptogenesis  (Evidence:domains)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 361 residues, 8177634-8178714Exon2: 2 residues, -Jump to Q9BZV8_HUMAN  
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Loci Cluster (Details)Loci: 4014 8177634-8178714 ~-1K 8324(-)Loci: 2735 8126150-8141634 ~-15K 8320(NECAP1)(+)Link out to UCSC