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1Q9BRR4_HUMAN*   Trembl (?) | Description Local Annotation Link Reference
General Information
NameN/A
DescriptionChrna3 protein (cholinergic receptor, nicotinic, alpha polypeptide 3).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0016021 integral to membrane (IEA)
0045211 postsynaptic membrane (IEA)
0005230 extracellular ligand-gated ion channel acti... (IEA)
0005216 ion channel activity (IEA)
0030594 neurotransmitter receptor activity (IEA)
0004889 nicotinic acetylcholine-activated cation-se... (IEA)
0006811 ion transport (IEA)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains assigned to SynO:
Neurotransmitter ligand-gated ion channels are transmembrane receptor-ion channel complexes that open transiently upon binding of specific ligands.llowing rapid transmission of signals at chemical synapses .Of the five families known.our have been shown to form a sequence-related superfamily. These are the gamma-aminobutyric acid type A (GABA-A).icotinic acetylcholine.lycine and the serotonin 5HT3 receptors. The ionotropic glutamate receptors () have a distinct primary structure.However.ll these receptors possess a pentameric structure (made up of varying subunits).urrounding a central pore. Each of these subunits contains a large extracellular N-terminal ligand-binding region; 3 hydrophobic transmembrane domains; a large intracellular region; and a fourth hydrophobic domain .This domain represents four transmembrane helices of a variety of neurotransmitter-gated ion-channels.
  IPR006029:Neurotransmitter-gated ion-channel transmembrane region
Neurotransmitter ligand-gated ion channels are transmembrane receptor-ion channel complexes that open transiently upon binding of specific ligands.llowing rapid transmission of signals at chemical synapses .Of the five families known.our have been shown to form a sequence-related superfamily. These are the gamma-aminobutyric acid type A (GABA-A).icotinic acetylcholine.lycine and the serotonin 5HT3 receptors. The ionotropic glutamate receptors () have a distinct primary structure.However.ll these receptors possess a pentameric structure (made up of varying subunits).urrounding a central pore. Each of these subunits contains a large extracellular N-terminal ligand-binding region; 3 hydrophobic transmembrane domains; a large intracellular region; and a fourth hydrophobic domain .This InterPro entry represents the GABA-A.icotinic.lycine.nd 5HT3 receptors.
  IPR006201:Neurotransmitter-gated ion-channel
InterPro domains unassigned to SynO:
Neurotransmitter ligand-gated ion channels are transmembrane receptor-ion channel complexes that open transiently upon binding of specific ligands.llowing rapid transmission of signals at chemical synapses .Of the five families known.our have been shown to form a sequence-related superfamily. These are the gamma-aminobutyric acid type A (GABA-A).icotinic acetylcholine.lycine and the serotonin 5HT3 receptors. The ionotropic glutamate receptors () have a distinct primary structure.However.ll these receptors possess a pentameric structure (made up of varying subunits).urrounding a central pore. Each of these subunits contains a large extracellular N-terminal ligand-binding region; 3 hydrophobic transmembrane domains; a large intracellular region; and a fourth hydrophobic domain .Nicotinic acetylcholine receptors are ligand-gated ion channels that mediate signaltransduction at the post-synaptic membrane of cholinergic synapses.uch asthe neuromuscular junction . They belong to a family of neurotransmitter-gated receptors.ncluding glycine.amma-aminobutyric-acid (GABA).erotonin 5HT3 receptors. These are oligomeric transmembrane(TM) complexes (pentamers of 2 alpha and 1 beta. gamma and 1 deltasubunit) that contain a central channel.hich transiently opens upon binding of a specific neurotransmitters. Their sequences are related and share the same topology: each hasan extracellular.lycosylated N-terminal ligand-binding domain; 3 hydrophobic TM regions.hich form the channel; a hydrophilic cytoplasmicdomain; followed by a fourth putative TM region . The nicotinic receptor ligand binding domain is a specialized pocket of aromatic and hydrophobic residues formed at interfaces between protein subunits that changes conformation to convert agonist binding into gating of an intrinsic ion channel . The expression of acetylcholine receptors is activated during muscledifferentiation and upon denervation of adult muscle . Receptor functionis regulated by phosphorylation and dephosphorylation by kinases andphosphatases present in the post-synaptic membranes . Most of thephosphorylation sites are located in the major intracellular loop betweenthe third and fourth TM regions and are closely spaced.
  IPR002394:Nicotinic acetylcholine receptor
Neurotransmitter ligand-gated ion channels are transmembrane receptor-ion channel complexes that open transiently upon binding of specific ligands.llowing rapid transmission of signals at chemical synapses .Of the five families known.our have been shown to form a sequence-related superfamily. These are the gamma-aminobutyric acid type A (GABA-A).icotinic acetylcholine.lycine and the serotonin 5HT3 receptors. The ionotropic glutamate receptors () have a distinct primary structure.However.ll these receptors possess a pentameric structure (made up of varying subunits).urrounding a central pore. Each of these subunits contains a large extracellular N-terminal ligand-binding region; 3 hydrophobic transmembrane domains; a large intracellular region; and a fourth hydrophobic domain .This entry presents the extracellular ligand binding domain of these ion channels. This domain forms a pentameric arrangement in the known structure.
  IPR006202:Neurotransmitter-gated ion-channel ligand-binding
IPR006202:Neur_chan_LBD 
Evalue:-110.045761108398 
Location:35-241IPR006029:Neur_chan_memb 
Evalue:-93.4948501586914 
Location:248-466
SequencesProtein: Q9BRR4_HUMAN (489 aa)
mRNA: BC006114
Local Annotation
Synapse Ontology
Postsynaptic compartment is represented by a patch of plasma membrane containing a packed array of neurotransmitter receptors and by an underlying dense matrix, the postsynaptic density (PSD).
sdb:0005 Postsynaptic compartment  (Evidence:keywords,domains)
this kind of receptor usually locates at the postsynaptic plasma membranous region.
sdb:0109 ionotropic receptor  (Evidence:keywords,domains)
priming for exocytosis prepares the calcium-dependent release and may involve partial fusion process. The vesicles are primed and become responsive to calcium.
sdb:0120 priming  (Evidence:keywords,domains)
?
sdb:0305 binding to postsynaptic receptor and internization  (Evidence:keywords,domains)
?
sdb:0328 transmitters release and endocytosis  (Evidence:keywords,domains)
KO assignmentK04805
  Level 3 annotation:
    cholinergic receptor, nicotinic, alpha polypeptide 3
  Level 2 annotation:
    Ion channels
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 46 residues, 76672451-76672588Exon2: 339 residues, 76680649-76681661Exon3: 38 residues, 76696420-76696530Exon4: 17 residues, 76698013-76698058Exon5: 48 residues, 76698172-76698312Exon6: 196 residues, 76700109-76700692Exon7: 2 residues, -Jump to Q9BRR4_HUMANExon1: 475 residues, 76674706-76676129Exon2: 339 residues, 76680649-76681661Exon3: 38 residues, 76696420-76696530Exon4: 17 residues, 76698013-76698058Exon5: 48 residues, 76698172-76698312Exon6: 91 residues, 76700109-76700377Exon7: 2 residues, -Jump to ACHA3_HUMAN  
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Loci Cluster (Details)Loci: 2903 76644960-76673513 ~-29K 12833(CHRNA5)(+)Loci: 4183 76672451-76700692 ~-28K 12834(-)Loci: 4184 76703690-76720642 ~-17K 12836(CHRNB4)(-)Loci: 4185 77041340-77169895 ~-129K 12842(RASGRF1)(-)Loci: 2902 76228773-76249938 ~-21K 12813(IDH3A)(+)Link out to UCSC