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1Q96L03_HUMAN*   Trembl (?) | Description Local Annotation Link Reference
General Information
NameN/A
DescriptionHypothetical protein loc128153 (hypothetical protein flj25725) (novel protein).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GON/A
Domain Architecture (Details)
InterPro domains unassigned to SynO:
Calmodulin (CaM) is recognized as a major calcium sensor and orchestrator of regulatory events through its interaction with a diverse group of cellular proteins. Three classes of recognition motifs exist for many of the known CaM binding proteins; the IQ motif as a consensus for Ca2+-independent binding and two related motifs for Ca2+-dependent binding.ermed18-14 and 1-5-10 based on the position of conserved hydrophobic residues .The regulatory domain of scallop myosin is a three-chain protein complex that switches on this motor in response to Ca2+ binding. Side-chain interactions link the two light chains in tandem to adjacent segments of the heavy chain bearing the IQ-sequence motif. The Ca2+-binding site is a novel EF-hand motif on the essential light chain and is stabilized by linkages involving the heavy chain and both light chains.ccounting for the requirement of all three chains for Ca2+ binding and regulation in the intact myosin molecule .
  IPR000048:IQ calmodulin-binding region
IPR000048:IQ 
Evalue:-4.74472761154175 
Location:56-76IPR000048:IQ 
Evalue:-3.67778062820435 
Location:33-53IPR000048:IQ 
Evalue:-2.53760194778442 
Location:92-112
SequencesProtein: Q96L03_HUMAN (361 aa)
mRNA: NM_138796
Local Annotation
Synapse Ontology
Calcium release from RyR (Ryanodine Receptor) in the SR (Sarcoplasmic Reticulum) is activated by the calcium induced-calcium-release
sdb:0325 RyR-CICR  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 32 residues, 215871317-215871411Exon2: 32 residues, 215888846-215888936Exon3: 29 residues, 215891061-215891143Exon4: 19 residues, 215908997-215909048Exon5: 36 residues, 215923222-215923326Exon6: 43 residues, 215981939-215982063Exon7: 70 residues, 216014298-216014502Exon8: 51 residues, 216022138-216022287Exon9: 46 residues, 216041682-216041815Exon10: 29 residues, 216102738-216102821Exon11: 42 residues, 216106986-216107107Exon12: 2 residues, -Jump to Q96L03_HUMAN  
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