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1Q96KS2_HUMAN*   Trembl (?) | Description Local Annotation Link Reference
General Information
NameN/A
DescriptionRich1b protein.
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005737 cytoplasm (IEA)
0005515 protein binding (IEA)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains assigned to SynO:
Endocytosis and intracellular transport involve several mechanistic steps: (1) for the internalisation of cargo molecules.he membrane needs to bend to form a vesicular structure.hich requires membrane curvature and a rearrangement of the cytoskeleton; (2) following its formation.he vesicle has to be pinched off the membrane; (3) the cargo has to be subsequently transported through the cell and the vesicle must fuse with the correct cellular compartment.Members of the Amphiphysin protein family are key regulators in the early steps of endocytosis.nvolved in the formation of clathrin-coated vesicles by promoting the assembly of a protein complex at the plasma membrane and directly assist in the induction of the high curvature of the membrane at the neck of the vesicle. Amphiphysins contain a characteristic domain.nown as the BAR (BinAmphiphysinRvs)-domain.hich is required for their in vivo function and their ability to tubulate membranes . The crystal structure of these proteins suggest the domain forms a crescent-shaped dimer of a three-helix coiled coil with a characteristic set of conserved hydrophobic.romatic and hydrophilic amino acids. Proteins containing this domain have been shown to homodimerise.eterodimerise or.n a few cases.nteract with small GTPases.
  IPR004148:BAR
IPR004148:BAR 
Evalue:-73.0043640136719 
Location:1-216
SequencesProtein: Q96KS2_HUMAN (226 aa)
mRNA: AJ306732
Local Annotation
Synapse Ontology
endocytotic reaction via coated pits
sdb:0119 endocytotic reaction  (Evidence:domains)
clathrin-coat uncoating means clathrin was shed from the budding vesicle membrane.
sdb:0122 clathrin-coat uncoating  (Evidence:domains)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 290 residues, 24838214-24839082Exon2: 209 residues, 24849605-24850226Exon3: 58 residues, 24854291-24854461Exon4: 80 residues, 24858185-24858419Exon5: 54 residues, 24860808-24860965Exon6: 32 residues, 24862592-24862684Exon7: 40 residues, 24866303-24866417Exon8: 29 residues, 24868225-24868306Exon9: 29 residues, 24871110-24871192Exon10: 39 residues, 24871752-24871864Exon11: 44 residues, 24873424-24873552Exon12: 29 residues, 24878492-24878574Exon13: 25 residues, 24878732-24878801Exon14: 39 residues, 24883018-24883130Exon15: 27 residues, 24887172-24887249Exon16: 39 residues, 24887482-24887594Exon17: 26 residues, 24889328-24889402Exon18: 37 residues, 24896036-24896141Exon19: 15 residues, 24897787-24897827Exon20: 50 residues, 24934030-24934176Exon21: 2 residues, -Jump to Q68EM7_HUMANExon1: 14 residues, 24873513-24873552Exon2: 25 residues, 24878732-24878801Exon3: 39 residues, 24883018-24883130Exon4: 27 residues, 24887172-24887249Exon5: 39 residues, 24887482-24887594Exon6: 26 residues, 24889328-24889402Exon7: 37 residues, 24896036-24896141Exon8: 15 residues, 24897787-24897827Exon9: 19 residues, 24934030-24934083Exon10: 2 residues, -Jump to Q96KS2_HUMAN  
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